ORAL CAVITY IN AIDS--REGULATION/FUNCTION OF IGA

艾滋病口腔疾病--IGA 的调节/功能

• 批准号: 2458667
• 负责人: SUSAN JACKSON
• 金额: $ 27.75万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458667
• 关键词: AIDS; B lymphocyte; HIV infections; RNase protection assay; T lymphocyte; antiviral antibody; clinical research; cytokine; cytotoxicity; enzyme linked immunosorbent assay; gene expression; human immunodeficiency virus; human subject; immunoglobulin A; intracellular; mucosal immunity; neutralizing antibody; oral mucosa; polymerase chain reaction; protein structure function; salivary glands; secretion; tissue /cell culture; virus replication

DESCRIPTION: Description (Adapted from Investigators Abstract): Saliva is normally inhibitory for HIV replication. One of the factors which may be involved in this is the primary defense factor in the oral cavity, namely secretory IgA. IgA is transported into secretions by secretory component (SC) synthesized by epithelial cells in the salivary glands. The expression of SC is regulated by cytokines. Since HIV infection has a profound effect on the immune system, the properties of salivary IgA antibodies of HIV infected patients will be examined including their specificity structure and function. Secondly, investigations will be initiated on the alterations of salivary cytokines or on cytokine expression by cells of the oral cavity which may influence oral manifestation of HIV infection. Third, the potential for intracellular formation of IgA anti-HIV/HIV complexes will be examined, which could lead to virus neutralization within epithelial cells in the oral cavity.

描述：描述（调整了调查人员摘要）：唾液是 通常抑制艾滋病毒复制。 可能是 参与这是口腔中的主要防御因素，即 分泌Iga。 Iga被分泌部分运送到分泌物 （SC）由唾液腺中的上皮细胞合成。 表达 SC的细胞因子调节。 由于艾滋病毒感染具有深远的影响 在免疫系统上，HIV的唾液IgA抗体的特性 受感染的患者将进行检查，包括其特异性结构和 功能。 其次，将开始对变更的调查 口腔细胞的唾液细胞因子或细胞因子表达 这可能会影响艾滋病毒感染的口服表现。 第三， IgA抗HIV/HIV复合物的细胞内形成可能是 检查的，这可能导致上皮细胞内中和病毒 在口腔中。