NEUROBIOLOGIC SUBSTRATES OF STUTTERING

口吃的神经生物学基础

• 批准号: 2014234
• 负责人: Anne L Foundas
• 金额: $ 8.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2014234
• 关键词: academic achievement; age difference; audiometry; auditory cortex; behavioral /social science research tag; clinical research; gender difference; handedness; human subject; magnetic resonance imaging; neuroanatomy; neuropsychological tests; speech; speech recognition; stuttering

DESCRIPTION: The candidate proposes a five year period of support to permit h to develop her research skills so that she may become an independent research scientist capable of utilizing sophisticated techniques to perform quantitativ analyses of MRI data. In this proposal she will employ these techniques to investigate the neurobiologic substrate of stuttering, but she suggests that t techniques may ultimately be used to address a variety of brain-behavior relations in clinical populations. Specific aspects of the proposal which warrant attention include the following: The major focus of research has been the attempt to define the anatomic basis cognitive and other brain functions by means of the quantitative analysis of M images. She lists 8 publications in peer-reviewed journals, 3 manuscripts currently In Press and 4 manuscripts under review. She is first author of 6 o the published/in press manuscripts. Research Program (modified from the PI's Specific Aims): The major goal of th project is to study neuroanatomic models of stuttering. To achieve these goal the PI proposes to conduct four experiments that investigate the relationship behavioral asymmetries in people who stutter and nonstutterers. Experiment 1 will investigate the relationship of speech production to asymmetries in anterior perisylvian speech-language regions (pars triangularis pars opercularis). Experiment 2 will investigate the relationship between speech perception asymmetries in posterior speech-language regions (planum temporale). Experiment 3 will investigate the relationship between motor dexterity and asymmetries in cortical and subcortical motor regions (central suclus, globus plallidus). Experiments 1, 2, and 3 will be limited to consistent right handers. As hand preference may be an important independent variable, left handed stutterers and left handed nonstutterers will be investigated in Experiment 4 using the same measures to be employed in Experiments 1, 2, and 3. This project will focus on cerebral dominance in stutterers. The major postulate of the study is that people who stutter have anatomic and behavioral anomalies of dominance.

描述：候选人提出了五年的支持，以允许 h发展她的研究技能，以便她成为独立的 研究科学家能够利用复杂的技术执行 MRI数据的定量分析。 在这个建议中，她将雇用这些 研究口吃的神经生物学底物的技术，但她 建议最终可以使用T技术来解决各种 临床人群中的脑行为关系。 特定方面 提案保证关注包括以下内容： 研究的主要重点是试图定义解剖学 通过定量的基础认知和其他大脑功能 M图像的分析。 她列出了同行评审期刊的8个出版物，3 目前正在媒体上的手稿和4项手稿正在审查中。 她是第一个 作者6 o已发表/在新闻稿中。 研究计划（根据PI的特定目的进行修改）： TH项目是研究口吃的神经解剖模型。 实现这些 目标PI提议进行四个研究 口吃和非分类者的人的关系行为不对称。 实验1将调查语音生产与 前perisylvian语音语言区域中的不对称区域（PARS 三角形pars opercularis）。 实验2将研究 后部语音感知不对称之间的关系 语音语言区域（Planum Playale）。 实验3将调查 运动敏捷性与皮质和不对称性之间的关系 皮层运动区域（中央Suclus，Globus Plallidus）。 实验 1、2和3将仅限于一致的右手。 作为手偏好 可能是重要的自变量，左手口吃和左手 将使用相同 实验1、2和3中采用的措施。 该项目将集中于口吃者中的脑占优势。 专业 该研究的假设是口吃有解剖学和 行为异常。