Developmental Stuttering: MRI Studies in Children

发育性口吃：儿童 MRI 研究

• 批准号: 6798231
• 负责人: Anne L Foundas
• 金额: $ 7.43万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6798231
• 关键词: behavior test; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain morphology; clinical research; developmental disease /disorder; gender difference; genetic polymorphism; handedness; language; magnetic resonance imaging; middle childhood (6-11); neuropsychological tests; patient oriented research; psychomotor function; questionnaires; speech; stuttering

DESCRIPTION (provided by applicant): There is compelling new evidence that adults with persistent developmental stuttering (PDS) have anomalous anatomy in perisylvian speech, language, and motor areas on volumetric MRI, but these imaging methods have not been used to study children who do and do not stutter. Because of recent strong evidence that children with PDS are likely to be genetically different from children with transient developmental stuttering (TDS), it is important to study these two groups as it is unclear whether they are also biologically distinct in terms of brain morphology. The major aim of this project is to use in vivo volumetric MRI methods to study speech, language, and motor regions in children with PDS (n=30), children with TDS (n=30) and normally fluent children (n=30) matched for sex, handedness, age, and education. Regions of interest (R0ls) implicated by a model of stuttering positing an outer linguistic and an inner phonological-motor loop will be studied, including: (1) perisylvian speech-language areas (outer linguistic loop), and (2) cortical-subcortical motor areas (inner phonatory loop). It is hypothesized that asymmetry patterns of perisylvian and motor regions will be disrupted in children who stutter, and anomalous anatomy defined as altered volumes and disturbed gyral patterns may dissociate the children with TDS from those with PDS and from controls. It is unclear, however, whether the PDS group will have distinct anatomic features compared to the TDS group, or whether the PDS group will have more anatomic anomalies compared to the TDS group. Anatomical regions may deviate in concert, suggesting a severity effect, or specific regions may deviate independently, suggesting that multiple combinations result in stuttering. We will investigate whether specific regions are more likely to be atypical in severely dysfluent subjects, or whether specific configurations are associated with specific stuttering symptoms or with measures of speech motor control. We are also interested in whether there are distinct anatomical features within subgroups based on sex, and hand preference, because we found important differences in adults with PDS based on these variables. These proposed studies will provide a biological framework to learn more about brain morphology in children who do and do not stutter, provide information to develop targeted behavioral and pharmacological interventions, and may lead to earlier detection of children at risk for developmental stuttering.

描述（由申请人提供）：有令人信服的新证据表明，具有持续的发育口吃（PDS）的成年人在perisylvian语音，语言和运动区域的体积MRI上具有异常的解剖结构，但是这些成像方法并未用于研究那些做和没有停顿的孩子。由于最近有力的证据表明，患有PDS的儿童可能在遗传上与瞬时发育性口吃（TDS）的儿童不同，因此研究这两组很重要，因为目前尚不清楚他们在脑形态上是否在生物学上也与生物学上有所不同。该项目的主要目的是使用体内体积MRI方法来研究PDS儿童（n = 30）的言语，语言和运动区域，TDS（n = 30）的儿童（n = 30）以及通常流利的儿童（n = 30）（n = 30）的性别，惯用性，年龄，年龄和教育。将研究以口吃模型提出外语言和内部语音运动环的含义的感兴趣区域（R0L），包括：（1） Perisylvian语音语言区域（外语言环）和（2）皮层皮质运动区域（内部语音环）。可以假设的是，口吃的儿童以及定义为变化的体积和干扰的陀螺模式的异常解剖结构会破坏periSylvian和运动区域的不对称模式，可能会使患有TDS的儿童与PDS和对照组解离儿童。但是，尚不清楚PDS组与TDS组相比是否具有不同的解剖特征，或者与TDS组相比，PDS组是否具有更多的解剖异常。解剖区域可能会偏离，表明严重性效应或特定区域可能会独立偏离，这表明多种组合会导致口吃。我们将调查特定区域是否更可能在严重失调的受试者中是非典型的，或者特定的配置是否与特定的口吃症状或语音运动控制量有关。我们也对子组中是否有不同的解剖特征感兴趣 基于性别和手偏好，因为我们发现基于这些变量的PD的成年人的重要差异。这些拟议的研究将提供一个生物学框架，以了解有关脑形态的更多信息。