MECHANISMS OF RESPIRATORY DYSRHYTHMIA IN SLEEP

睡眠呼吸节律失常的机制

• 批准号: 2378800
• 负责人: TEODORO V SANTIAGO
• 金额: $ 25.05万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2378800
• 关键词: REM sleep; acid base balance; brain circulation; brain electrical activity; carbon dioxide tension; carotid body; denervation; electroencephalography; electromyography; electrooculography; gender difference; goats; hypocapnia; hypoventilation; hypoxia; membrane potentials; pulmonary respiration; sleep apnea

Multiple factors interact to influence respiratory output in sleep. This proposal deals with three factors which have been less studied in sleep but which are hypothesized to be significant contributors to the generation or perpetuation of respiratory dysrhythmias in this state. These factors are changes in brain blood flow during sleep, the effect of sleep on the strength of respiratory afterdischarge, and the presence of an oscillatory respiratory stimulus in the awake and sleeping subject. The experiments proposed will investigate the respiratory consequences of altering cerebral perfusion during slow wave and REM sleep under conditions of hypoxia and hypercapnia, the possibility that sleep with or without hypoxia impairs respiratory afterdischarge and, if so, whether sexual differences exist in this response, and how oscillations in an otherwise persistent respiratory stimulus may cause episodic hypoventilation. The studies are to be performed in the unanesthetized awake and sleeping goat. This species is ideal for the proposed studies for the following reasons: (a) its unique cerebrovascular anatomy allows continuous, dynamic measurement of brain blood flow and when necessary, its control, which is not possible with other methods; (b) it demonstrates reproducible respiratory afterdischarge using a localized carotid body stimulus; and (c) it has well-characterized electrometric and ventilatory changes during wakefulness, slow wave and REM sleep that are similar to human beings. Sleep-disordered breathing is a relatively common disease with significant morbidity and mortality. Because its pathogenesis remains unclear, therapy remains less than ideal. The proposed studies should help in the understanding of factors that lead to the genesis of respiratory dysrhythmias in sleep.

多个因素相互作用以影响睡眠中的呼吸输出。 这 提案处理三个因素，这些因素在睡眠中的研究较少 但假设这是造成的重要贡献者 在该状态下产生或永续存在呼吸障碍。 这些因素是睡眠期间脑血流的变化 睡在呼吸后的强度上，存在 在清醒和睡眠对象中进行振荡呼吸刺激。这 提出的实验将研究 在慢波中改变大脑灌注，然后在下面睡觉 缺氧和高碳酸血症的疾病，与或 没有缺氧会损害呼吸后期的过递送，如果是的话，是否 这种反应中存在性别差异，以及如何振荡 否则持续的呼吸刺激可能会引起偶发性 不足。这些研究将在未经麻醉的情况下进行 醒着睡觉的山羊。该物种是拟议研究的理想选择 由于以下原因：（a）其独特的脑血管解剖结构允许 脑血流的连续，动态测量，必要时， 它的控制，其他方法是不可能的； （b）它证明了 使用局部颈动脉体可再现的呼吸后期 刺激； （c）它具有良好的电视和通风 清醒期间的变化，慢波和REM睡眠类似 人类。 睡眠呼吸是一种相对常见的疾病 具有明显的发病率和死亡率。因为它的发病机理仍然存在 尚不清楚，治疗仍然不理想。拟议的研究应有助于 在理解导致呼吸系统起源的因素中 睡眠中的心律不齐。