EXERCISE IN HYPERTENSIVE POSTMENOPAUSAL WOMEN

绝经后高血压女性的锻炼

• 批准号: 2442300
• 负责人: DOUGLAS R SEALS
• 金额: $ 36.22万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-25 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442300
• 关键词: adipose tissue; aerobic exercise; blood glucose; blood pressure; cardiovascular disorder prevention; clinical research; disease /disorder proneness /risk; essential hypertension; female; glucose tolerance; high density lipoproteins; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; longitudinal human study; low density lipoprotein; low salt diet; nutrition related tag; postmenopause; therapy compliance

DESCRIPTION (Adapted from the Applicant's Abstract): In women, the prevalence of cardiovascular diseases (CVD), particularly coronary heart disease (CHD) and cerebrovascular disease, increases markedly after menopause. An increased prevalence of hypertension is the primary factor contributing to this rise in CVD. Stage 1 ("mild") essential hypertension, both diastolic hypertension (diastolic arterial blood pressure [DBP] 90-99 mmHg with either normal or elevated systolic arterial blood pressure [SBP]) and isolated systolic hypertension (ISH -- SBP l40-159 mmHg with normal DBP), accounts for most of the increase in BP-related CVD risk. Adverse changes in other (i.e., non-BP) risk factors for CHD also contribute to the increased prevalence of CVD in postmenopausal women. As such, several health organizations have stated that any anti-hypertensive therapy should also, if possible, improve these other CHD risks factors. Regular aerobic exercise lowers BP in some hypertensive populations, but its efficacy for reducing BP and improving other CHD risk factors in postmenopausal women with either diastolic hypertension or ISH is unknown. Accordingly, the present study will determine: (Specific Aim 1) if regular aerobic exercise lowers BP at rest in postmenopausal women with Stage I essential hypertension compared to an active treatment control (i.e, moderate dietary sodium [Na] restriction); (Specific Aim 2) if the magnitudes of the reductions in BP in response to regular exercise are similar in postmenopausal women with diastolic hypertension vs. those with ISH; and (Specific Aim 3) if regular aerobic exercise also can improve other risk factors for CHD in this population. To achieve these aims, over a 5-year study period, 200 otherwise healthy postmenopausal women with Stage 1 essential hypertension (100 with diastolic hypertension and 100 with ISH) will undergo extensive screening and baseline measurements followed by random assignment to a 26-week period of either aerobic exercise intervention (moderate-intensity walking) or active treatment control (dietary Na restriction). BP at rest, aerobic exercise capacity, compliance to the exercise intervention (or control), and other CHD risk factors will be measured during and/or after the 26-week periods. Systemic hemodynamic, autonomic, neurohumoral, and structural determinants of BP also will be examined to gain insight into the mechanisms by which exercise lowers BP in these women.

描述（改编自申请人的摘要）：在女性中 心血管疾病的患病率（CVD），尤其是冠心病 疾病（CHD）和脑血管疾病，之后显着增加 绝经。 高血压的患病率增加是主要因素 在CVD中促进了这一增加。 第1阶（“轻度”）必需高血压， 两种舒张压高血压（舒张动脉血压[DBP] 90-99 MMHG具有正常或升高收缩压的动脉血压[SBP]） 和分离的收缩压高血压（ISH-SBP L40-159 mmHg，正常 DBP），占BP相关CVD风险的大部分增加。 不利 CHD的其他（即非BP）风险因素的变化也有助于 绝经后妇女CVD的患病率增加。 因此，有几个 卫生组织已经指出，任何抗高血压疗法都应 另外，如果可能的话，改善了这些其他冠心心风险因素。 常规有氧运动 运动在某些高血压种群中降低了BP，但其功效 减少BP并改善绝经后妇女的其他CHD危险因素 舒张期高血压或ISH尚不清楚。 因此， 目前的研究将确定：（具体目标1）如果常规有氧运动 在绝经后妇女的静止状态下降低BP I阶段I的重要 与主动治疗对照相比高血压（即中度饮食 钠[NA]限制）； （特定目标2）如果 响应定期运动的BP减少相似 舒张期高血压的绝经后妇女与患有ISH的妇女；和 （特定目标3）如果定期有氧运动也可以改善其他风险 该人群中冠心病的因素。 为了实现这些目标，在5年中 研究期，有200个健康的绝经后妇女患有第1阶段 必需的高血压（100例患有舒张期高血压，ISH 100） 将经过广泛的筛选和基线测量结果 随机分配26周的有氧运动 干预（中等强度步行）或主动治疗控制 （饮食限制）。 BP休息，有氧运动能力，合规性 进行运动干预（或控制）和其他CHD风险因素 在26周期间和/或之后进行测量。 系统性血流动力学， BP的自主，神经肿瘤和结构决定因素也将是 检查以了解运动降低BP的机制 这些女人。