SIGNAL TRANSDUCTION MECHANISMS AND CELL FUNCTION

信号转导机制和细胞功能

• 批准号: 2748680
• 负责人: B M WAITE
• 金额: $ 19.99万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2748680
• 关键词: SIGNAL; TRANSDUCTION; MECHANISMS; CELL; FUNCTION

DESCRIPTION (Applicant's Description): The purpose of this program is to train a new generation of researchers and educators in signal transduction mechanisms. Signal transduction is the means by which cells respond to internal and external stimuli. These controls regulate the physiology, metabolism and gene control of the cell. As such, the signal transduction is fundamental to all cells and is critical to the understanding of many pathologic states. In this program the applicants focus on training related to cancer; cancer has been termed a disease of aberrant signaling mechanisms. The program, however, is not limited to problems in cancer and involves many clinical problems and departments. Here the applicants propose that the training program faculty from the Departments of Medicine, Biochemistry, Physiology/Pharmacology and Microbiology/Immunology will be responsible for the didactic and research training of seven fellows. Four of these fellows will be predoctoral and three will be postdoctoral. The postdoctorals can have either the M.D. or Ph.D. degree. The program will be 4-5 years for predoctoral and 2-3 years for postdoctoral fellows. The facilities of the Departments involved plus those of the Comprehensive Cancer Center of Wake Forest University will be available to the trainees.

描述（申请人的描述）：该计划的目的是培训新一代的研究人员和教育者，以进行信号转导机制。信号转导是细胞对内部和外部刺激反应的手段。 这些控制调节细胞的生理，代谢和基因控制。 因此，信号转导对所有细胞都是基础的，对于理解许多病理状态至关重要。 在该计划中，申请人专注于与癌症有关的培训；癌症已被称为异常信号传导机制。 但是，该计划不仅限于癌症的问题，还涉及许多临床问题和部门。 申请人在这里建议，医学，生物化学，生理学/药理学和微生物学/免疫学部门的培训计划将负责七个研究员的教学和研究培训。 这些研究员中有四个将是主要的，三个将是博士后。 博士后可以拥有M.D.或Ph.D.程度。 该计划将在五年前为4 - 5年，而博士后研究员将为2 - 3年。涉及的部门的设施以及Wake Forest University综合癌症中心的设施将提供给受训者。