PEDIATRIC LUNG & HEART COMPLICATIONS OF HIV INFECTION

小儿肺

• 批准号: 2317431
• 负责人: Mark D. Schluchter
• 金额: $ 19.69万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2317431
• 关键词: PEDIATRIC; LUNG; HEART; COMPLICATIONS; HIV

The overall objective of this program is to conduct a "natural" history study to characterize the pulmonary and cardiovascular disorders that occur in association with vertically transmitted (mother to child during gestation or during the perinatal time period) human immunodeficiency virus (HIV) infection in children. The study will be coordinated among six geographically separated centers (Baylor College of Medicine, Houston; Children's Hospital/Harvard Medical School, Boston; Mt. Sinai School of Medicine, New York City; Presbyterian Hospital/Columbia University, New York City; UCLA School of Medicine, Los Angeles; and University of California, San Francisco) and the Clinical Coordinating Center (The Cleveland Clinic Foundation). The Program of the Clinical Coordinating Center will include participation in the development of the study protocol, the detailed manual of operations, appropriate data acquisition via distributed data entry, and establishment of suitable data processing procedures. A major activity of the Clinical Coordinating Center will be the development of procedures for control of the quality of the data. A comprehensive program of data management for the Natural History Study will include data review and editing, reduction, display and analysis, and generation of reports and publications.

该计划的总体目的是进行“自然”历史 研究表征肺和心血管疾病的研究 发生与垂直传播相关的（母亲在 妊娠期或围产期期间）人类免疫缺陷 儿童病毒（艾滋病毒）感染。 该研究将在 六个地理分开的中心（贝勒医学院， 休斯顿;波士顿儿童医院/哈佛医学院；西奈山 纽约市医学院；长老会医院/哥伦比亚 纽约大学；加州大学洛杉矶分校医学院，洛杉矶；和 加利福尼亚大学，旧金山）和临床协调 中心（克利夫兰诊所基金会）。 临床协调中心的计划将包括 参与研究方案的开发，详细 操作手册，通过分布式数据采集适当的数据 进入和建立合适的数据处理程序。 一个 临床协调中心的主要活动将是 制定控制数据质量的程序。 一个 自然历史研究的数据管理综合计划 将包括数据审核和编辑，减少，显示和分析， 以及报告和出版物的产生。