Testing the Combination of Behavioral Activation and Problem Solving as a Novel Behavioral Smoking Cessation Intervention for Smokers with HIV in Botswana
测试行为激活和解决问题相结合作为博茨瓦纳艾滋病毒吸烟者的新型戒烟行为干预措施
基本信息
- 批准号:10594565
- 负责人:
- 金额:$ 64.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAddressAdultAfricaAfrica South of the SaharaAfricanAnxietyBehaviorBehavior TherapyBehavioralBotswanaCaringChronic Obstructive Pulmonary DiseaseCounselingCountryDataDecentralizationDeveloping CountriesEpidemicEvidence based practiceGeneral PopulationGoalsHIVHIV InfectionsHIV/AIDSHealthIncomeIndividualInfrastructureInterventionLifeMediatingMediatorMental DepressionModelingMorbidity - disease rateMotivationMyocardial InfarctionNicotine DependenceOutcomePathway interactionsPatternPersonsPharmacotherapyPilot ProjectsPopulationProblem SolvingProfessional counselorPublic HealthRandomizedResearchRewardsRiskRoleSamplingSiteSmokerSmokingSmoking BehaviorSmoking Cessation InterventionTelephoneTestingTobacco DependenceTobacco Use CessationTobacco smoking behaviorTobacco useTuberculosisWithdrawalantiretroviral therapybehavior changebehavioral economicscare deliveryclinical infrastructurecommon symptomcomorbiditycostdepressive symptomsdesignefficacy evaluationexperiencehealth care availabilityhealth care deliveryhigh riskintervention effectlow and middle-income countriesmedication compliancemobile computingmortalitynegative affectnicotine replacementnovelpilot testprimary outcomeproblem solving therapyprogramspsychological distresspsychological symptomrandomized trialreduce tobacco usereinforcerrelapse riskscale upskillssmoking cessationtrial comparingtrial designvareniclinevirtualworking group
项目摘要
Project Summary
Tobacco smoking is one of the most preventable causes of morbidity and mortality worldwide and has
become a growing epidemic in developing countries in Africa. Among HIV+ individuals on antiretroviral
therapy, smoking causes more life-year loss than HIV infection. While both behavioral approaches and
pharmacotherapy are typically used together in high income countries, pharmacotherapy is largely unavailable
in sub-Saharan Africa due to cost. Instead, developing and evaluating behavioral smoking cessation
interventions, which could be realistically disseminated is a priority for addressing tobacco use among persons
with HIV in countries such as Botswana. Yet, unique aspects of HIV (e.g., high rate of depressive symptoms)
and delivery of care in such settings (e.g., decentralized, limited infrastructure) must be considered when
designing a behavioral approach in LMICs such as Botswana.
Depressive symptoms are common in HIV populations and often comorbid with smoking, and addressing
depressive symptoms has been related to better smoking cessation rates. Behavioral activation therapy,
rooted in a behavioral economics framework, has been effective at treating depression and preliminary data in
the US, including in our group, suggests that it may effectively address smoking as well. Behavioral activation
aims to increase engagement in healthy rewarding activities (i.e., substitute reinforcers) by reducing patterns of
avoidance, withdrawal, and inactivity, and decrease activities that enhance the rewarding aspects of smoking
(i.e., complementary reinforcers). In a parallel way, problem solving approaches have been used with HIV
populations for behavior change regarding medication adherence, have also been successful at decreasing
depressive symptoms, and are ideally suited for helping smokers select and implement personalized
behavioral activation activities to quit smoking. We therefore created the novel Behavioral Activation/Problem
Solving for Smoking Cessation (BAPS-SC), culturally adapted it and pilot tested it in Botswana and found it to
be feasible and appealing and to have preliminary evidence of efficacy.
We will conduct a 1:1 randomized trial comparing a BAPS-SC with standard counseling for smoking
cessation in 650 HIV+ smokers in Botswana. We will leverage HIV care sites and deliver the interventions by
phone to extend the reach of skilled practitioners. We will also assess whether depressive symptoms moderate
the effect of BAPS-SC and test our proposed mediating pathways for the interventions' effects
This project will determine whether the novel intervention is superior to standard counseling to establish a
new paradigm for LMIC smoking cessation programs. We will also further our understanding of whether
depressive symptoms, reinforcers, and problem solving are modifiable mediators of smoking. Leveraging the
HIV care infrastructure will facilitate scale-up in sub-Saharan African settings where HIV is common and
smoking continues to emerge as a threat to HIV+ individuals' health and survival.
项目概要
吸烟是全世界发病率和死亡率最可预防的原因之一,并且已
成为非洲发展中国家日益严重的流行病。在接受抗逆转录病毒治疗的艾滋病病毒感染者中
治疗中,吸烟导致的生命年损失比艾滋病毒感染还要多。虽然行为方法和
药物治疗通常在高收入国家一起使用,但药物治疗基本上不可用
由于成本原因,在撒哈拉以南非洲地区。相反,制定和评估戒烟行为
能够切实传播的干预措施是解决人们烟草使用问题的一个优先事项
在博茨瓦纳等国家感染艾滋病毒。然而,艾滋病毒的独特之处(例如,抑郁症状的发生率很高)
必须考虑在此类环境(例如分散的、有限的基础设施)中提供护理
为博茨瓦纳等中低收入国家设计行为方法。
抑郁症状在艾滋病毒人群中很常见,并且通常与吸烟共存,并且解决
抑郁症状与更好的戒烟率有关。行为激活疗法,
植根于行为经济学框架,在治疗抑郁症方面一直有效,并且初步数据
美国,包括我们小组中的国家,表明它也可以有效地解决吸烟问题。行为激活
旨在通过减少健康奖励活动(即替代强化物)的模式来增加参与度
回避、戒断和不活动,并减少可增强吸烟益处的活动
(即补充强化物)。同时,解决问题的方法也被用于艾滋病毒治疗
人群在药物依从性方面的行为改变也成功地减少了
抑郁症状,非常适合帮助吸烟者选择和实施个性化
戒烟的行为激活活动。因此,我们创造了新颖的行为激活/问题
解决戒烟问题(BAPS-SC),在文化上进行了调整,并在博茨瓦纳进行了试点测试,发现它可以
可行、有吸引力,并有初步的有效性证据。
我们将进行 1:1 随机试验,将 BAPS-SC 与标准吸烟咨询进行比较
博茨瓦纳 650 名 HIV+ 吸烟者戒烟。我们将利用艾滋病毒护理站点并通过以下方式提供干预措施:
电话以扩大熟练从业人员的联系范围。我们还将评估抑郁症状是否温和
BAPS-SC 的效果并测试我们提出的干预效果的中介途径
该项目将确定新颖的干预措施是否优于标准咨询,以建立一个
中低收入国家戒烟计划的新范例。我们还将进一步了解是否
抑郁症状、强化物和问题解决是吸烟的可改变中介因素。利用
艾滋病毒护理基础设施将促进在艾滋病毒普遍存在的撒哈拉以南非洲地区扩大规模
吸烟继续对艾滋病病毒感染者的健康和生存构成威胁。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ROBERT GROSS其他文献
ROBERT GROSS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ROBERT GROSS', 18)}}的其他基金
Testing the Combination of Behavioral Activation and Problem Solving as a Novel Behavioral Smoking Cessation Intervention for Smokers with HIV in Botswana
测试行为激活和解决问题相结合作为博茨瓦纳艾滋病毒吸烟者的新型戒烟行为干预措施
- 批准号:
10171829 - 财政年份:2020
- 资助金额:
$ 64.8万 - 项目类别:
Testing the Combination of Behavioral Activation and Problem Solving as a Novel Behavioral Smoking Cessation Intervention for Smokers with HIV in Botswana
测试行为激活和解决问题相结合作为博茨瓦纳艾滋病毒吸烟者的新型戒烟行为干预措施
- 批准号:
10725267 - 财政年份:2020
- 资助金额:
$ 64.8万 - 项目类别:
Testing the Combination of Behavioral Activation and Problem Solving as a Novel Behavioral Smoking Cessation Intervention for Smokers with HIV in Botswana
测试行为激活和解决问题相结合作为博茨瓦纳艾滋病毒吸烟者的新型戒烟行为干预措施
- 批准号:
10400935 - 财政年份:2020
- 资助金额:
$ 64.8万 - 项目类别:
Determinants and Outcomes of Nicotine Metabolite Ratio in HIV + Smokers
HIV 吸烟者尼古丁代谢比率的决定因素和结果
- 批准号:
10254935 - 财政年份:2020
- 资助金额:
$ 64.8万 - 项目类别:
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
测试新型药物遗传学和依从性优化治疗,以提高艾滋病毒吸烟者戒烟治疗的有效性
- 批准号:
10689095 - 财政年份:2019
- 资助金额:
$ 64.8万 - 项目类别:
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
测试新型药物遗传学和依从性优化治疗,以提高艾滋病毒吸烟者戒烟治疗的有效性
- 批准号:
10225475 - 财政年份:2019
- 资助金额:
$ 64.8万 - 项目类别:
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
测试新型药物遗传学和依从性优化治疗,以提高艾滋病毒吸烟者戒烟治疗的有效性
- 批准号:
10818945 - 财政年份:2019
- 资助金额:
$ 64.8万 - 项目类别:
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
测试新型药物遗传学和依从性优化治疗,以提高艾滋病毒吸烟者戒烟治疗的有效性
- 批准号:
10017932 - 财政年份:2019
- 资助金额:
$ 64.8万 - 项目类别:
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
测试新型药物遗传学和依从性优化治疗,以提高艾滋病毒吸烟者戒烟治疗的有效性
- 批准号:
10477202 - 财政年份:2019
- 资助金额:
$ 64.8万 - 项目类别:
相似国自然基金
本体驱动的地址数据空间语义建模与地址匹配方法
- 批准号:41901325
- 批准年份:2019
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
时空序列驱动的神经形态视觉目标识别算法研究
- 批准号:61906126
- 批准年份:2019
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
针对内存攻击对象的内存安全防御技术研究
- 批准号:61802432
- 批准年份:2018
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
大容量固态硬盘地址映射表优化设计与访存优化研究
- 批准号:61802133
- 批准年份:2018
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
IP地址驱动的多径路由及流量传输控制研究
- 批准号:61872252
- 批准年份:2018
- 资助金额:64.0 万元
- 项目类别:面上项目
相似海外基金
Longitudinal Modeling of Pro-Inflammatory Cytokines, Hazardous Alcohol Use, and Cerebral Metabolites as Predictors of Neurocognitive Change in People with HIV
促炎细胞因子、有害酒精使用和脑代谢物的纵向建模作为 HIV 感染者神经认知变化的预测因子
- 批准号:
10838849 - 财政年份:2024
- 资助金额:
$ 64.8万 - 项目类别:
Assessing the real-world impact of a low nicotine product standard for smoked tobacco in New Zealand
评估新西兰低尼古丁产品标准对吸食烟草的现实影响
- 批准号:
10665851 - 财政年份:2023
- 资助金额:
$ 64.8万 - 项目类别:
Effects of Nicotine Concentration Levels in E-cigarettes on Biomarkers of Exposure to Toxicants and Tobacco Use Behaviors
电子烟中尼古丁浓度水平对有毒物质暴露和烟草使用行为生物标志物的影响
- 批准号:
10678555 - 财政年份:2023
- 资助金额:
$ 64.8万 - 项目类别:
Randomized clinical trial to test the efficacy of a smartphone app for smoking cessation for nondaily smokers
随机临床试验,测试智能手机应用程序对非日常吸烟者戒烟的功效
- 批准号:
10715401 - 财政年份:2023
- 资助金额:
$ 64.8万 - 项目类别:
3/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
3/4-美国早期肝移植联盟-前瞻性酒精相关性肝病队列评估(ACCELERATE-PACE)
- 批准号:
10711001 - 财政年份:2023
- 资助金额:
$ 64.8万 - 项目类别: