Strengthening Research Capacity in Innovative Global Health Technologies for Non-Communicable Diseases in Uganda

加强乌干达非传染性疾病创新全球卫生技术的研究能力

• 批准号: 10594570
• 负责人: ANDREW Martin ROLLINS
• 金额: $ 24.65万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594570
• 关键词: Address; Africa South of the Sahara; Applications Grants; Area; Artificial Intelligence; Biocompatible Materials; Biomedical Engineering; Biomedical Research; Cardiovascular Diseases; Categories; Chronic; Clinical Investigator; Collaborations; Data Analytics; Development; Diagnostic; Disease; Doctor of Philosophy; Drug Delivery Systems; Faculty; Goals; Health Technology; Healthcare; Hematological Disease; Industry; Institution; Journals; Movement Disorders; Outcome; Output; Peer Review; Positioning Attribute; Privatization; Public Health; Publications; Research; Research Personnel; Research Project Grants; Research Support; Students; Technology; Therapeutic; Training; Training Programs; Uganda; Universities; biomedical imaging; design; experience; global health; innovation; low and middle-income countries; point-of-care diagnostics; programs; screening; technological innovation; tool

This new D43 application proposes a training program entitled “Strengthening Research Capacity in Innovative Global Health Technologies for Non-Communicable Diseases in Uganda” (SIGHT). This program will build on the extensive 32-year training record of the Uganda-CWRU Research Collaboration (UCRC), a partnership between Case Western Reserve University and Makerere University The burden of non-communicable diseases and disorders (NCD) is growing rapidly in low- and middle- income countries (LMIC) and sub-Saharan Africa (SSA) and Uganda particularly. Developing capacity for biomedical research in LMICs is necessary for managing these new healthcare challenges, and encouraging progress is being made. We assert that building capacity in particular for biomedical engineering (BME) research is critical to development of much-needed screening, diagnostic, and therapeutic technology relevant to the context of LMICs. Training programs to build this capacity are lacking. We have identified three broad categories of NCDs to target in the SIGHT program that will particularly benefit from building capacity for technology innovation: cardiovascular disease, blood disorders, and chronic movement disorders. These target areas have been identified as critical public health needs by program leaders and other stakeholders. We have also identified four areas of technology focus as highest priorities for building capacity in BME research expertise at MU in Uganda. These are: biomaterials and drug delivery, point-of-care diagnostics, biomedical imaging, and data analytics and artificial intelligence. These technology tools are cross-cutting in their potential to address high-priority NCD healthcare needs. The SIGHT program has been designed with the long-term goal of building and strengthening the capacity of academic, public, private, and NGO institutions in Uganda to conduct biomedical engineering research, train biomedical engineers up to a PhD level and grow a local biomedical engineering industry based on local needs. SIGHT aims to contribute to this goal by: Aim 1: Training Ugandan students in the BME Ph.D. program at CWRU (6 within the proposed project period) Aim 2: Supporting research projects for M.S. students at MU in BME-adjacent fields (approx. 10 per year). Aim 3: Providing opportunities for MU investigators to enhance their research experience and expertise. Expected outcomes of the SIGHT program include: ● Ph.D. researchers prepared to fill faculty and research positions at research institutions in Uganda. ● M.S. graduates who are prepared to fill research positions or go on to Ph.D. training. ● MU investigators who are better prepared to carry out high quality BME research. ● A robust network of research collaborations between BME and clinical investigators at CWRU and MU. ● Increased research output, including publications in peer reviewed journals and grant proposals.

这项新的 D43 申请提出了一项名为“加强研究能力”的培训计划 乌干达针对非传染性疾病的创新性全球卫生技术”（SIGHT）。 该计划将以乌干达-CWRU 研究合作 32 年的广泛培训记录为基础 (UCRC)，凯斯西储大学和麦克雷雷大学之间的合作伙伴关系 在中低收入国家，非传染性疾病和失调 (NCD) 的负担正在迅速增加 收入国家（LMIC）和撒哈拉以南非洲（SSA）和乌干达，特别是发展能力。 中低收入国家的生物医学研究对于应对这些新的医疗保健挑战并鼓励 我们断言，特别是生物医学工程（BME）方面的能力建设正在取得进展。 研究对于开发急需的相关筛查、诊断和治疗技术至关重要 缺乏针对中低收入国家的能力建设培训计划。 我们已经确定了 SIGHT 计划中针对的三大类非传染性疾病，特别是 从技术创新能力建设中受益：心血管疾病、血液疾病和 这些目标领域已被确定为关键的公共卫生需求。 我们还确定了四个最重要的技术重点领域。 乌干达大学 BME 研究专业能力建设的优先事项是：生物材料和药物。 交付、护理点诊断、生物医学成像、数据分析和人工智能。 这些技术工具具有跨领域的潜力，可以满足高度优先的非传染性疾病医疗保健需求。 SIGHT 计划的长期目标是建立和加强 乌干达学术、公共、私人和非政府组织机构开展生物医学工程的能力 研究、培养生物医学工程师直至博士学位并发展本地生物医学工程产业 SIGHT 旨在通过以下方式为这一目标做出贡献： 目标 1：在 CWRU 的 BME 博士课程中培训乌干达学生（在拟议的项目期间有 6 名学生） 目标 2：支持 MU 硕士生在 BME 相关领域的研究项目（每年约 10 个）。 目标 3：为密苏里大学研究人员提供增强研究经验和专业知识的机会。 SIGHT 计划的预期成果包括： ● 博士研究人员准备填补乌干达研究机构的教职和研究职位。 ● 准备填补研究职位或继续攻读博士学位的硕士毕业生。 ● 密苏里大学的研究人员为开展高质量的 BME 研究做好了更充分的准备。 ● BME 与 CWRU 和 MU 的临床研究人员之间建立了强大的研究合作网络。 ● 增加研究成果，包括在同行评审期刊上发表的文章和资助提案。