LOW-DOSE ORAL CONTRACEPTIVES AND CARDIOVASCULAR DISEASE

低剂量口服避孕药与心血管疾病

• 批准号: 2314555
• 负责人: DAVID Stuart SISCOVICK
• 金额: $ 57.1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2314555
• 关键词: LOW; DOSE; ORAL; CONTRACEPTIVES; CARDIOVASCULAR

The objective of this contract is to conduct a population-based case- control study to evaluate the relative and attributable risks of first episodes of fatal and non-fatal acute myocardial infarction (AMI) and stroke for users of oral contraceptives (OCs). Areas of interest include investigation of the risks among users of OC preparations containing less- than or equal-to 50ug estrogen, for those preparations containing the least estrogen and for the combined effects of smoking, age, and other risk factors for cardiovascular disease. The offeror proposes to make use of a case-ascertainment network including acute care hospitals, emergency medical services, physicians, paramedics and county medical examiners in King, Snohomish and Pierce Counties in Washington State. It is estimated that 150 cases of AMI, 175 cases of stroke and 580 controls will be identified over a 40-month data collection period.

该合同的目的是进行基于人群的案件 - 控制研究以评估第一次的相对风险 致命和非致命急性心肌梗塞（AMI）和非致命性急性心肌梗死的发作 口服避孕药（OCS）的用户中风。 感兴趣的领域包括 调查包含较少的OC准备使用者之间的风险 比或等于50ug雌激素，对于那些包含最少的制剂 雌激素以及吸烟，年龄和其他风险的综合作用 心血管疾病的因素。 要约人建议利用 病例娱乐网络，包括急诊医院，紧急情况 医疗服务，医生，护理人员和县医学检查员 华盛顿州的国王，斯诺霍米什和皮尔斯县。 估计 150例AMI，175例中风和580例对照将是 在40个月的数据收集期内确定。