Administrative Core

行政核心

• 批准号: 10555682
• 负责人: DAVID Tobin FELSON
• 金额: $ 123.81万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555682
• 关键词: Address; Aging; Agreement; Alabama; Ancillary Study; Area; Biomechanics; Boston; California; Clinical Data; Collaborations; Communication; Communities; Crystal Formation; Data; Data Collection; Degenerative polyarthritis; Disease; Disputes; Ensure; Epidemiologic Factors; Etiology; Faculty; Feedback; Fostering; Funding; Funding Agency; Goals; Grant; Image; Institution; Institutional Review Boards; Iowa; Knee; Laboratories; Leadership; Magnetic Resonance Imaging; Measurement; Mission; Monitor; Muscle function; Observational Study; Occupational activity of managing finances; Outcome; Output; Pain; Paper; Physical activity; Physical assessment; Policies; Postdoctoral Fellow; Prevention; Process; Productivity; Protocols documentation; Publishing; Reaction; Reading; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Risk Factors; San Francisco; United States National Institutes of Health; Universities; career; cohort; data management; data sharing; disability; experience; human subject; innovation; insight; loss of function; meetings; multidisciplinary; novel; operation; patient oriented; programs

ABSTRACT Administrative Core The mission of the Multicenter Osteoarthritis (MOST) study is to conduct, facilitate, and promote high impact research on the etiology and prevention of osteoarthritis (OA) and its consequences of pain and loss of function. During the proposed 4th cycle of MOST (MOST4), we plan to accomplish this goal through the acquisition, management, analysis and sharing of data on OA, risk factors and functional consequences of disease. The primary goal of the MOST4 Administrative Core is to ensure that processes are in place and functioning to support the accomplishment of this mission. The Administrative Core will manage finances, and the following interactions: 1) internally among the study units (the Cores (Clinical Data Collection and Management, Analysis, Imaging) and Projects); 2) with external researchers; 3) between institutions involved in the MOST study including Boston University; University of Alabama, Birmingham; University of California, San Francisco; University of Iowa; the funding agency (NIA); reading centers; and specialized laboratories.The Administrative Core will be under the leadership of Core co-Leaders Drs. David Felson and Tuhina Neogi, supported by an Executive Committee consisting of the other Cores' leaders. The overall team of MOST4 investigators include a mix of senior experienced NIH-funded faculty and junior faculty establishing their careers with a focus on studies of OA, pain and disability. The first cycle of the MOST study (MOST1) was funded in 2001, and investigators affiliated with this cohort have a long history of collaboration, having published over 180 papers reporting important findings related to OA epidemiology and risk factors, pain, function, and other outcomes. Among the unique features of the study has been the multidisciplinarity of its investigators and research. A range of topics have been studied, including MRI findings in the knee, pain sensitization, biomechanical data such as the ground reaction force, measurement of muscle function, studies of crystal deposition, assessment of physical activity, among others. The current proposal for the 4th cycle of MOST (MOST4) represents an expansion of this multidisciplinary focus. The goals of the Administrative Core are to provide leadership to successfully manage the overall study's execution; plan, direct and integrate all MOST study activities; provide transparent communication across projects and cores; and foster cross-project collaboration. We will accomplish these goals through providing leadership and administrative oversight for the following Specific Aims: Scientific & Operational Management, including single Institutional Review Board processes; Financial Management; Study Output Management & Dissemination; Pilot Grant Program; Community Advisory Board Engagement; Communications & External Collaboration. Through these activities, the Administrative Core will ensure the successful operations of MOST4 under the strong and collaborative leadership of the investigator team.

摘要 行政核心 多中心骨关节炎 (MOST) 研究的使命是开展、促进和促进具有高影响力的研究 研究骨关节炎（OA）的病因和预防及其疼痛和功能丧失的后果。 在拟议的 MOST 第四周期（MOST4）期间，我们计划通过收购来实现这一目标， 管理、分析和共享 OA、危险因素和疾病功能后果的数据。这 MOST4 管理核心的主要目标是确保流程到位并正常运行 支持这一使命的完成。行政核心将管理财务，以及以下内容 相互作用：1）内部研究单元之间（核心（临床数据收集和管理、分析、 成像）和项目）； 2）与外部研究人员合作； 3）参与MOST研究的机构之间 包括波士顿大学；阿拉巴马大学伯明翰分校；加州大学旧金山分校； 爱荷华大学；资助机构（NIA）；阅读中心；和专业实验室。行政 核心将在核心联合领导人 Drs 的领导下。 David Felson 和 Tuhina Neogi，得到了 执行委员会由其他核心领导人组成。 MOST4 调查员的整个团队包括 由 NIH 资助的经验丰富的资深教师和以学习为重点的初级教师组成 OA、疼痛和残疾。 MOST 研究 (MOST1) 的第一轮于 2001 年获得资助，研究人员 与该群体有悠久的合作历史，已发表 180 多篇论文报告 与 OA 流行病学和危险因素、疼痛、功能和其他结果相关的重要发现。其中 该研究的独特之处在于其调查人员和研究的多学科性。一系列主题 已被研究，包括膝盖的 MRI 结果、疼痛敏化、地面等生物力学数据 反作用力、肌肉功能测量、晶体沉积研究、身体活动评估、 除其他外。当前 MOST 第四周期 (MOST4) 的提案代表了这一点的扩展 多学科焦点。行政核心的目标是提供领导以成功管理 整体研究的执行；规划、指导和整合所有 MOST 研究活动；提供透明 跨项目和核心的沟通；并促进跨项目协作。我们将实现这些目标 通过为以下具体目标提供领导和行政监督：科学和 运营管理，包括单一机构审查委员会流程；财务管理；学习 输出管理与传播；试点资助计划；社区咨询委员会参与； 沟通与外部合作。通过这些活动，行政核心将确保 在研究者团队的强有力和协作领导下，MOST4 的成功运行。