SUBCHRONIC & CHRONIC TOXICITY OF ISOBUTENE

亚慢性

• 批准号: 2308316
• 负责人: BILLY J CHOU
• 金额: $ 39万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-31 至 1996-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308316
• 关键词: SUBCHRONIC; CHRONIC; TOXICITY; ISOBUTENE

The objective of this study is to determine the subchronic and chronic toxicity/carcinogenicity study of Isobutene administered by inhalation to Fisher 344 rats and B6C3F1 mice. The contract will include Phase I which is the basic award and includes the development of analytical chemistry, generation and monitoring methods. Phase 2 consists of 1. 13-Week Study: 10 animals/sex/specie shall be treated at each of five dose levels plus controls for 13-weeks 2. 104-Week Study: Fifty animals/sex/specie shall be treated for 104 weeks at 3 dose levels plus controls.

这项研究的目的是确定亚基和慢性 毒性/致癌性研究通过吸入给予的异丁烯 Fisher 344只大鼠和B6C3F1小鼠。 合同将包括第一阶段 是基本奖项，包括开发分析化学， 生成和监测方法。 阶段2包括 1。13周的研究：应在每个 五个剂量水平加13周的控件 2。104周的研究：五十只动物/性别/特征应进行104 3剂量水平加对照的几周。