BRAIN AND TISSUE BANK FOR DEVELOPMENTAL DISORDERS

发育障碍的大脑和组织库

• 批准号: 2314851
• 负责人: H. Ronald Zielke
• 金额: $ 36.32万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-16 至 1996-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2314851
• 关键词: BRAIN; TISSUE; BANK; DEVELOPMENTAL; DISORDERS

The objective of this project is to systemically collect and distribute high quality biopsy and/or freshly autopsied tissues from "unaffected" (control) individuals and from patients who had been diagnosed to have a known or unknown forms of mental retardation, developmental disabilities, or infants who dies of sudden infant death syndrome (SIDS). Among the conditions from whom specimens will be obtained include those with chromosome defects, mitochondrial myoencephalopathies, phenylketonuria and other aminoacidopathies, organic acidurias, maternal PKU, Rett syndrome, leukodystrophies, lysosomal storage disorders, dyslexia, autism, and other neurodevelopmental disorders. The repository will serve as a research resource for qualified investigators to support and facilitate research that will lead to an improved understanding of the etiology, pathology, pathogenesis, and clinical-pathological correlation of conditions that are associated with SIDS, mental retardation, learning and behavioral deficits. Since the repository will collect normal and abnormal brains at various prenatal and postnatal stages of development, it can also provide material for the longitudinal studies of brain development and its malformations.

该项目的目的是系统地收集和分发 来自“未受影响”的高质量活检和/或新鲜动体组织 （对照）个人和被诊断为具有的患者 已知或未知形式的智力障碍，发展 残疾或死于猝死综合症的婴儿 （SIDS）。 在将获得标本的条件中 包括染色体缺陷的那些，线粒体 肌脑病，苯酮尿症和其他氨基酸疾病， 有机酸尿，母体PKU，RETT综合征，白细胞营养不良，， 溶酶体储存障碍，阅读障碍，自闭症和其他 神经发育障碍。 存储库将作为研究 合格研究者支持和促进研究的资源 这将导致对病因，病理学， 发病机理和条件的临床病理相关性 与SIDS，智力低下，学习和行为相关 缺陷。 由于存储库将收集正常和异常的大脑 在各种产前和产后发展阶段，它也可以 为大脑发育的纵向研究提供材料 它的畸形。