Sex differences in cerebral pulsatility and implications for brain health

大脑搏动的性别差异及其对大脑健康的影响

• 批准号: 10556735
• 负责人: JILL NICOLE BARNES
• 金额: $ 15.54万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10556735
• 关键词: 4D MRI; Adult; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Biological Markers; Blood Vessels; Brain; Cardiac; Cerebrospinal Fluid; Cerebrovascular Circulation; Cerebrum; Cognitive; Data; Elderly; Goals; Hippocampus (Brain); Human; Impaired cognition; Internal carotid artery structure; Intervention; Knowledge; Link; Longevity; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Mission; Neurobiology; Patients; Physical activity; Play; Prevalence; Process; Public Health; Publishing; Recommendation; Regional Perfusion; Regulation; Research; Risk; Risk Factors; Role; Scanning; Sex Differences; Structure; Thick; Transcranial Doppler Ultrasonography; United States National Institutes of Health; Vascular Dementia; White Matter Hyperintensity; Wisconsin; Woman; Work; age related; basilar artery; biological sex; brain health; cardiorespiratory fitness; cerebral microvasculature; cerebrovascular health; cohort; disability; improved; innovation; intracranial artery; lifetime risk; men; middle age; middle cerebral artery; neuroimaging; parent grant; sex; stroke risk; successful intervention; tool; vascular risk factor

PROJECT SUMMARY Pulsatility is a measure of fluctuations in flow over the duration of a cardiac cycle. Increases in pulsatility in the cerebral vessels with advancing age have been linked to structural damage in the brain. Cerebral pulsatility is elevated in patients with vascular dementia and Alzheimer’s disease. The goal of our research is to understand age-related changes in cerebral blood flow regulation, how this impacts global and regional perfusion of the brain, and determine successful interventions for improving cerebral blood flow control. In order to understand age-related changes, it is critical to take into account sex differences and how the trajectory of these changes may differ between men and women. Our preliminary data shows that the rate of increase in cerebral pulsatility over the human lifespan is greater in women compared with men. This work suggests that women may be more vulnerable to changes in cerebral pulsatility with advancing age. In the parent grant, we have state-of-the-art neuroimaging tools available to assess cerebral pulsatility in multiple cerebral vessels in a large cohort of middle- aged and older adults. Therefore, the objectives of this supplement application are to leverage existing MRI scans to investigate biological sex differences in cerebral pulsatility. Our hypothesis is that there are sex differences in cerebral pulsatility that impact brain health. Importantly, this project will be the first to investigate sex differences in cerebral pulsatility and determine associations with neurobiological markers of brain health. Aim 1 will determine if there are sex differences in cerebral pulsatility in multiple intracranial arteries. Aim 2 will explore the influence of vascular risk factors and physical activity on cerebral pulsatility. Aim 3 will determine the impact of cerebral pulsatility on neurobiological markers of brain health and Alzheimer’s disease and then determine if these relationships are sex-specific. This project will provide essential information to determine sex differences in cerebral pulsatility. It will also explore the influence of physical activity and other vascular risk factors, and determine potential sex-specific associations with neurobiological markers of brain health that are important for the risk of Alzheimer’s disease and dementia. To achieve these aims, we will employ innovative MRI analysis from existing neuroimaging scans in a large cohort of middle-aged and older adults. This application aligns with recent recommendations published by the NIH emphasizing the need for human studies to identify and confirm biomarkers of vascular processes related to cognitive impairment. Upon completion, we will understand whether sex differences in cerebral pulsatility are contributing to a greater risk for Alzheimer’s disease and related dementias.

项目概要 搏动性是心动周期期间血流波动的量度。 随着年龄的增长，脑血管与大脑结构损伤有关。 血管性痴呆和阿尔茨海默氏病患者的血压升高。我们研究的目的是了解。 与年龄相关的脑血流调节变化，这如何影响大脑的整体和区域灌注 脑，并确定改善脑血流控制的成功干预措施。 与年龄相关的变化，考虑性别差异以及这些变化的轨迹是至关重要的 我们的初步数据显示，男性和女性的大脑搏动增加率可能有所不同。 与男性相比，女性的寿命更长。这项研究表明，女性的寿命可能更长。 随着年龄的增长，大脑搏动很容易发生变化。在家长补助金中，我们拥有最先进的技术。 神经影像工具可用于评估一大群中年人的多个脑血管的脑搏动 因此，该补充应用程序的目标是利用现有的 MRI。 通过扫描来研究大脑搏动的生物性别差异。我们的假设是存在性别。 重要的是，该项目将是第一个研究影响大脑健康的脑搏动差异。 大脑搏动的性别差异并确定与大脑健康的神经生物学标志物的关联。 目标 1 将确定多个颅内动脉的脑搏动是否存在性别差异。 探索血管危险因素和体力活动对脑搏动的影响，目标 3 将确定。 脑搏动对大脑健康和阿尔茨海默病的神经生物学标志物的影响，然后 确定这些关系是否具有性别特异性 该项目将提供确定性别的基本信息。 它还将探讨体力活动和其他血管风险的影响。 因素，并确定与大脑健康的神经生物学标志物之间潜在的性别特异性关联 对于降低阿尔茨海默病和痴呆症的风险非常重要。为了实现这些目标，我们将采用创新技术。 该应用程序对一大群中老年人的现有神经影像扫描进行 MRI 分析。 与 NIH 最近发布的建议一致，强调需要进行人体研究来确定 并确认与认知障碍相关的血管过程的生物标志物。完成后，我们将。 了解大脑搏动的性别差异是否会增加患阿尔茨海默病的风险 疾病和相关的痴呆症。