The Effect of Pesticide Exposure on Cognitive and Brain Development in Latino Children: PACE5 Administrative Supplement 2

农药接触对拉丁裔儿童认知和大脑发育的影响：PACE5 行政补充文件 2

• 批准号: 10551526
• 负责人: Thomas A. Arcury
• 金额: $ 22.08万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551526
• 关键词: 7 year old; Administrative Supplement; Agriculture; Anatomy; Behavioral; Brain; Brain imaging; Child; Child Development; Clothing; Cognitive; Conflict (Psychology); Development; Documentation; Emotional; Environment; Exposure to; Family; Farm; Home; Housing; Latino; Life; Literature; Longitudinal Studies; Measurement; Motor; Outcome; Parents; Participant; Pesticides; Population; Reporting; Research; Sensory; Siblings; Study of Latinos; Techniques; Vulnerable Populations; Work; agricultural pesticide; community based participatory research; dosimetry; early life exposure; environmental justice; farm worker; high risk; imaging study; life history; longitudinal design; neurobehavioral; neurodevelopment; neuroimaging; pesticide exposure; postnatal; prenatal; prenatal exposure; prospective

Concern is mounting that commonly used pesticides are detrimental to children. Children are rapidly undergoing cognitive, sensory, and motor development, and disruption of normal maturation can have life-long consequences. The extant literature strongly indicates that prenatal exposure to pesticides leads to abnormal neurobehavioral development. A recent brain imaging study further showed that prenatal pesticide exposure is associated with disrupted anatomical brain development. However, results concerning the consequences of postnatal pesticide exposure are much less conclusive. Some studies have reported neurobehavioral deficits following postnatal pesticide exposure, but just as many studies have reported no negative consequences. Currently there are no studies that assess the effects of postnatal pesticide exposure on brain development using anatomical or functional brain imaging. More conclusive research on the effects of postnatal exposure on neurodevelopment requires a highly exposed population, a longitudinal design, and careful quantification of exposure and outcomes. We propose a two-group, prospective, longitudinal study of Latino children 7 years of age with quarterly measurement of cumulative pesticide exposure using passive dosimetry wristbands as well as documentation of prenatal and early life exposure through life history techniques. Children from Latino seasonal farmworker families will be compared with children from Latino families not participating in farm work and not living in an agricultural environment. Children in Latino farmworker families are at particularly high risk of exposure. Not only are pesticides frequently used in their low quality housing, but they are also exposed to agricultural pesticides used in nearby fields brought home by parental/sibling farmworkers on clothing. Children will be followed for 2 years with measurement of neurobehavioral function at baseline, 1 year, and 2 years. Neuroimaging will be performed in a subset of participants with structural and functional brain organization assessed at baseline and two years later. Specific aims for this project are: Aim 1: Compare 2-year longitudinal and prenatal/early life pesticide exposure between children of Latino seasonal farmworkers and children of Latino parents who are not farmworkers. Aim 2: Compare 2-year longitudinal neurobehavioral and emotional and behavioral functioning among children of Latino seasonal farmworkers relative to children of Latino parents who are not farmworkers. Aim 3: Compare 2-year longitudinal anatomical and functional brain development between children of Latino seasonal farmworkers and children of Latino parents who are not farmworkers. Our nearly two decades of environmental justice (EJ) and community-based participatory research (CBPR) on pesticide exposure with farmworkers and their families provides an auspicious context to engage this vulnerable population in a study of both scientific and environmental justice importance.

人们越来越担心常用农药对儿童有害。孩子们很快 认知、感觉和运动发育以及正常成熟的破坏可能会影响终生 结果。现有文献强烈表明，产前接触农药会导致异常 神经行为发育。最近的一项脑成像研究进一步表明，产前接触农药会影响 与大脑解剖学发育中断有关。然而，关于后果的结果 产后农药暴露的结论还不太明确。一些研究报告了神经行为缺陷 产后接触农药后，但正如许多研究报告的那样，没有负面后果。 目前尚无研究评估产后接触农药对大脑发育的影响 使用解剖或功能性脑成像。关于产后暴露对健康的影响的更结论性研究 神经发育需要高度暴露的人群、纵向设计和仔细的量化 暴露和结果。我们提议对 7 岁的拉丁裔儿童进行一项两组、前瞻性、纵向研究 还使用被动剂量测定腕带每季度测量累积农药暴露量的年龄 通过生活史技术记录产前和生命早期的暴露情况。来自拉丁裔的孩子 季节性农场工人家庭将与不参加农场工作的拉丁裔家庭的孩子进行比较 并且不生活在农业环境中。拉丁裔农场工人家庭的儿童面临特别高的风险 的曝光量。他们的低质量住房不仅经常使用杀虫剂，而且还接触到 父母/兄弟姐妹农场工人在衣服上带回家的附近田地使用的农业杀虫剂。孩子们 将随访 2 年，测量基线、1 年和 2 年的神经行为功能。 神经影像检查将在具有大脑结构和功能的参与者子集中进行 在基线和两年后进行评估。该项目的具体目标是： 目标 1：比较 2 年 拉丁裔季节性农场工人和儿童之间的纵向和产前/早期农药接触 非农场工人的拉丁裔父母的孩子。目标 2：比较 2 年纵向神经行为和 拉丁裔季节性农场工人的孩子相对于拉丁裔季节性农场工人的孩子的情绪和行为功能 非农场工人的拉丁裔父母。目标 3：比较 2 年纵向大脑解剖结构和功能 拉丁裔季节性农场工人的孩子与非拉丁裔父母的孩子之间的发展 农场工人。我们近二十年的环境正义（EJ）和基于社区的参与 关于农场工人及其家人接触农药的研究（CBPR）为 让这些弱势群体参与一项具有科学和环境正义重要性的研究。

项目成果

Pesticides at work and at home: exposure of migrant farmworkers.

工作场所和家庭中的农药：农民工的接触。

• 发表时间: 2003-12-13
• 作者: Arcury, Thomas A;Quandt, Sara A
• 通讯作者: Quandt, Sara A

Pesticides in the homes of farmworkers: Latino mothers' perceptions of risk to their children's health.

农场工人家中的农药：拉丁裔母亲对孩子健康风险的看法。

• 发表时间: 2007-04
• 作者: Rao, Pamela;Quandt, Sara A;Doran, Alicia M;Snively, Beverly M;Arcury, Thomas A
• 通讯作者: Arcury, Thomas A

Longitudinal Assessment of Blood Cholinesterase Activities Over 2 Consecutive Years Among Latino Nonfarmworkers and Pesticide-Exposed Farmworkers in North Carolina.

北卡罗来纳州拉丁裔非农业工人和接触农药的农场工人连续两年血液胆碱酯酶活性的纵向评估。

• 发表时间: 2015-08
• 影响因子: 3.2
• 作者: Quandt, Sara A;Pope, Carey N;Chen, Haiying;Summers, Phillip;Arcury, Thomas A
• 通讯作者: Arcury, Thomas A

Urinary Cotinine Levels Among Latino Tobacco Farmworkers in North Carolina Compared to Latinos Not Employed in Agriculture.

北卡罗来纳州拉丁裔烟草农场工人与未从事农业工作的拉丁裔工人的尿可替宁水平相比。

• 发表时间: 2016
• 作者: Arcury, Thomas A;Laurienti, Paul J;Talton, Jennifer W;Chen, Haiying;Howard, Timothy D;Summers, Phillip;Quandt, Sara A
• 通讯作者: Quandt, Sara A

Cancer Knowledge Among Mexican Immigrant Farmworkers in North Carolina.

北卡罗来纳州墨西哥移民农场工人的癌症知识。

• 发表时间: 2019-06
• 作者: Furgurson, Katherine F;Sandberg, Joanne C;Hsu, Fang;Mora, Dana C;Quandt, Sara A;Arcury, Thomas A
• 通讯作者: Arcury, Thomas A