Administrative Core

行政核心

• 批准号: 10549476
• 负责人: Viviana A Simon
• 金额: $ 25.35万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-21 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10549476
• 关键词: Achievement; Animal Model; Antibodies; B-Lymphocytes; COVID-19 pandemic; Collaborations; Communication; Coronavirus; Coronavirus Infections; Coronavirus spike protein; Data; Databases; Decision Making; Ensure; Environment; Evaluation; Goals; Humoral Immunities; Immune; Immune response; Immunity; Immunologist; Infection; Infrastructure; Institution; Interdisciplinary Study; Laboratories; Leadership; Manuscripts; Monitor; Monoclonal Antibodies; National Institute of Allergy and Infectious Disease; Occupational activity of managing finances; Office of Administrative Management; Pennsylvania; Performance; Philadelphia; Physicians; Policies; Pre-Clinical Model; Preparation; Principal Investigator; Procedures; Progress Reports; Public Health; Reagent; Recombinants; Recording of previous events; Reporting; Research; Research Institute; Research Personnel; Research Project Grants; Resource Allocation; Resource Sharing; Resources; Sampling; Sarbecovirus; Scientist; Services; Specificity; Strategic Planning; Structural Biologist; Transfer Agreement; United States National Institutes of Health; Universities; Vaccination; Vaccines; Variant; Viral; Washington; betacoronavirus vaccine; conflict resolution; coronavirus vaccination; cost; cross reactivity; dashboard; data access; data harmonization; data management; data quality; design; efficacy evaluation; efficacy testing; experimental study; flexibility; future pandemic; human model; imprint; material transfer agreement; medical schools; meetings; multidisciplinary; pandemic coronavirus; programs; quality assurance; response; risk mitigation; seasonal coronavirus; social media; symposium; synergism; vaccine candidate; vaccine development; ward; web page; zoonotic coronavirus

The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for better understanding of the mechanisms controlling broadly protective immune responses and generating vaccine candidates able to elicit such responses. The program project entitled “Programming Long-lasting Immunity to Coronaviruses (PLUTO)” proposes a comprehensive research plan towards designing pan- sarbecovirus and pan-betacoronavirus vaccines with broad protection by applying in-depth B cell characterization in the context of coronavirus immune histories imprinted by successive vaccinations and/or infections. Two complementary research projects will establish correlates of robust, durable and protective coronavirus humoral immunity (Project 1) as well as design and test efficacy of viral variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. The Administrative Core led by one of the two Principal Investigators, Dr. Viviana Simon, will function as a coordinating hub of the program providing a strong overall administrative infrastructure. The proposed activities and services of the Administrative Core are to provide overall management and program coordination, to facilitate communication within the program, to monitor progress within the projects and to prioritize, allocate, and manage resources. It will also support cooperation between the Research Projects and Service Cores by putting in place transfer agreements, data management plans and conflict resolution procedures. The Antibody Core will develop a large panel of recombinant monoclonal antibodies (mAbs) against coronavirus spike proteins to aid in defining specificity of immune responses elicited by coronavirus infection and/or vaccination in humans and animal models. The Animal Model Core will provide a central resource with approvals, facilities, and expertise to assess efficacy of broadly cross-reactive coronavirus antibodies and vaccines in robust pre-clinical models against a spectrum of coronaviruses, including Select Agents. A multidisciplinary team of scientists from five institutions who have an outstanding track record of working collaboratively will conduct the proposed studies. The Research Projects will collaborate across projects and with the Antibody and Animal Model Cores, coordinated by the Administrative Core. The integrated and synergistic activities across Projects and Cores will drive successful completion of the program project's ambitious research agenda, enabling achievement of the long-term PLUTO goal of developing variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. These findings will contribute to curbing the current SARS-CoV-2 pandemic and mitigate the risk of future pandemics with coronaviruses.

SARS-CoV-2 大流行代表了一场特殊的公共卫生危机，凸显了我们需要 更好地理解控制广泛保护性免疫反应和产生的机制 候选疫苗能够引起这种反应，该计划项目名为“持久编程”。 对冠状病毒的免疫（PLUTO）”提出了一项全面的研究计划，旨在设计泛 通过深入应用 B 细胞，提供广泛保护的 sarbecovirus 和 pan-betacoronavirus 疫苗 连续疫苗接种所印记的冠状病毒免疫史背景下的表征 和/或感染。两个互补的研究项目将建立稳健、持久的关联。 和保护性冠状病毒体液免疫（项目1）以及病毒的设计和功效测试 防变种泛 sarbecovirus 和泛 betacoronavirus 疫苗，由其中之一领导。 两位首席研究员 Viviana Simon 博士将担任该项目的协调中心 提供强大的整体行政基础设施。 行政核心是提供整体管理和计划协调，以促进 计划内的沟通，监控项目的进展并确定优先顺序、分配和 它还将通过以下方式支持研究项目和服务核心之间的合作。 制定传输协议、数据管理计划和冲突解决程序。 Antibody Core 将开发大量针对冠状病毒的重组单克隆抗体 (mAb) 刺突蛋白有助于确定冠状病毒感染引起的免疫反应的特异性和/或 人类和动物模型的疫苗接种将提供核心资源 用于评估广泛交叉反应的冠状病毒抗体的功效的批准、设施和专业知识， 针对一系列冠状病毒（包括 Select Agent A）的稳健临床前模型中的疫苗。 由来自五个机构的多学科科学家团队组成，他们拥有出色的工作记录 合作将进行拟议的研究。研究项目将跨领域合作。 项目以及抗体和动物模型核心，由行政部门协调 核心。跨项目和核心的综合和协同活动将推动成功。 完成该计划项目雄心勃勃的研究议程，从而实现长期目标 PLUTO 的目标是开发防变异的泛 sarbeco 病毒和泛 β 冠状病毒疫苗。 研究结果将有助于遏制当前的 SARS-CoV-2 大流行并减轻未来的风险 冠状病毒引起的流行病。