POPULATION-BASED NATURAL HISTORY OF CERVICAL NEOPLASIA

基于人群的宫颈肿瘤自然史

• 批准号: 3627419
• 负责人: MARIO PACHECO
• 金额: $ 38.35万
• 依托单位: FUNDACION COSTARRICENSE PARA LA DOCENCIA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3627419
• 关键词: Caribbean islands; Central America; biopsy; blood chemistry; cancer risk; cervical /vaginal smear; cervix disorder; cervix neoplasms; cytodiagnosis; data collection; female; human papillomavirus; human subject; interview; longitudinal human study; neoplasm /cancer epidemiology; tissue /organ preservation

In order to assess the relationship of infection with the human papillomaviruses (HPV) to risk of subsequent cervical neoplasia, a follow-up study of 10,000 women with no evidence of cytologic abnormalities will be conducted. This study will be conducted in a region of Costa Rica that has an incidence rate of cervical cancer approximately 6 times higher than that observed in the United States. At the beginning of this 5-year project, a random sample of the female population within the study region will be identified and recruited for study participation. From each woman, a Pap smear, cervical lavage, blood specimen and personal interview will be obtained. This will allow an examination of risk factors related to prevalent cervical disease. Subsequently these women will be followed passively through matching identification numbers of subjects against the Costa Rican national cytology and cancer registries. Women with incident cervical abnormalities will be identified and matched with non-cases for subsequent case-control analyses. These analyses will enable the assessment of risk in relation to prior evidence of infection with HPV and other agents, allowing further definition of the natural history of cervical abnormalities. In addition, collected data will enable identification of those factors associated with the progression of low-grade abnormalities to higher grade disease.

为了评估感染与人的关系 乳头瘤病毒（HPV），有宫颈肿瘤的风险，A 10,000名妇女的后续研究，没有细胞学证据 将进行异常。 这项研究将在 哥斯达黎加地区的发生率是宫颈癌的发生率 比美国观察到的大约6倍。 在 这个5年项目的开始，是女性的随机样本 研究区域内的人口将被确定和招募 研究参与。 来自每个女人，一个子宫颈抹片，宫颈灌洗， 将获得血液标本和个人面试。 这将允许 检查与普遍的宫颈疾病有关的危险因素。 随后，这些妇女将通过匹配被动地跟随 针对哥斯达黎加国民的受试者的识别号 细胞学和癌症登记。 有事件宫颈的妇女 将确定异常并与非案例匹配 随后的病例对照分析。 这些分析将使 与先前感染HPV感染的风险评估 和其他代理，允许进一步定义 宫颈异常。 此外，收集的数据将启用 识别与进展相关的因素 高级疾病的低级异常。