Patient-oriented research and mentoring in preterm birth toxicogenomics

以患者为中心的早产毒理基因组学研究和指导

• 批准号: 10542363
• 负责人: TRACY A. MANUCK
• 金额: $ 16.36万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10542363
• 关键词: Address; Advisory Committees; Air Pollution; Award; Biological Assay; Biological Markers; Biological Monitoring; Biometry; Caring; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Complement; Complex; Complex Mixtures; Data; Diabetes Mellitus; Diet; Dimensions; Educational workshop; Effectiveness; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Epigenetic Process; Exposure to; Faculty; Fellowship; Fetal Growth Retardation; Funding; Future; Gene Expression; Genetic; Genotype; Goals; Grant; Health; High Risk Woman; Home; Human; Inflammation; Inflammatory; Knowledge; Leadership; Maternal Messenger RNA; Maternal-fetal medicine; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Mission; Monitor; Mutation; National Institute of Environmental Health Sciences; Neonatology; Nitric Oxide Pathway; North Carolina; Patient Self-Report; Pharmacogenomics; Phase; Physicians; Placenta; Play; Postdoctoral Fellow; Pregnancy; Pregnant Women; Premature Birth; Prevention therapy; Progesterone; Recruitment Activity; Recurrence; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Risk Reduction; Role; Scientist; Serum; Statistical Methods; Surveys; Survivors; Testing; Time; Toxic Environmental Substances; Toxicogenomics; Training; Training Programs; Translational Research; United States National Institutes of Health; Urine; Woman; Work; Writing; career; career development; cohort; disability; drinking water; early pregnancy; gene environment interaction; global health; high risk; improved; indexing; instructor; metal metabolism; mortality; multidimensional data; multidisciplinary; neonate; next generation; patient oriented research; premature; prevent; prospective; psychosocial; racial disparity; recruit; relapse prevention; response; skills; social; toxicant; training opportunity

PROJECT SUMMARY This K24 proposal builds on over a decade of clinical and translational research – which the candidate – Dr. Tracy Manuck, MD, MSc, has focused on spontaneous preterm birth (SPTB). In this application, Dr. Manuck has recruited a team of multidisciplinary faculty experts to collaborate and support her in this endeavor, one that reflects the breadth and depth of UNC’s resources in environmental research. This work will greatly augment her current portfolio in patient-oriented research, allowing her to expand her current work and incorporate environmental contaminants into her current R01 funded study (R01-MD011609), creating a rich, multi- dimensional dataset. Candidate: Dr. Manuck is a recognized thought leader in the pharmacogenomics of SPTB. She has won numerous national accolades and has led high-impact clinical prematurity studies; here, she seeks to complement these skills by incorporating toxicogenomics into her research. Mentoring Plan/Environment: Dr. Manuck has an established track record in research training, including serving as Maternal Fetal Medicine (MFM) fellowship research director and a small group instructor for 2 graduate-level grant writing courses for fellows and junior faculty. However, competing administrative and clinical responsibilities limit her available time for mentorship. K24 award support will enable a more comprehensive mentoring portfolio within prematurity, and help to develop the critical mass of researchers investigating reproductive health effects of environmental contaminant exposure that is urgently needed in this field. With K24 support, she will have the appropriate time and resources to mentor advanced trainees (e.g., postdoctoral fellows, junior faculty) in their pursuit of independent funding. Dr. Manuck will leverage UNC’s extensive resources to accomplish this goal, including NIH-funded centers and training programs, networks and collaborations, and global health institutes. Career Goals and Objectives: Dr. Manuck will accomplish the following career development aims, including: Career Aim 1 - Expand knowledge of environmental health; Career Aim 2 - Improve mentorship skills; Career Aim 3 - Strengthen the ability to disseminate scientific results. Research Plan: Dr. Manuck will leverage her R01 study (currently recruiting) to evaluate the effects of exposure to pro-inflammatory environmental contaminants as an additional key driver of SPTB. She will integrate mentorship across the research aims: Aim 1 – Quantify exposure to environmental contaminants during pregnancy through self-report and biomonitoring of maternal urine, serum, and placentas; Aim 2 – Determine which contaminant or combination of contaminants is most strongly associated with SPTB; and Aim 3 – Test the effects of gene x environment interactions on recurrent SPTB risk. This plan offers a framework for Dr. Manuck’s training in the incorporation of environmental contaminants into prematurity studies, with potential for lifelong impact on the >450,000 babies delivered too soon in the US each year, while simultaneously providing a platform for mentoring future investigators committed to patient-oriented research.

项目概要 这项 K24 提案建立在十多年的临床和转化研究的基础上 - 候选人 - 博士。 Tracy Manuck，医学博士、理学硕士，专注于自发性早产 (SPTB)。在该应用中，Manuck 博士研究了自发性早产。 招募了一支由多学科专家组成的团队来合作并支持她的这一努力， 这项工作反映了北卡罗来纳大学环境研究资源的广度和深度。这项工作将极大地增强她的能力。 目前以患者为导向的研究组合，使她能够扩展当前的工作并整合 环境污染物纳入她目前的 R01 资助研究 (R01-MD011609)，创造了丰富的、多 候选人：Manuck 博士是 SPTB 药物基因组学领域公认的思想领袖。 她寻求获得众多国家级荣誉，并领导了具有高影响力的临床早产研究； 通过将毒物基因组学纳入她的研究中来补充这些技能： Manuck 博士在研究培训方面拥有良好的记录，包括担任母胎医学 (MFM) 奖学金研究主任和 2 门研究生级别资助写作课程的小组讲师 然而，相互竞争的行政和临床职责限制了她的可用时间 K24 奖励支持将在早产儿领域提供更全面的指导组合，以及 帮助培养足够数量的研究人员来调查环境对生殖健康的影响 在 K24 的支持下，她将有适当的时间来应对该领域急需的污染物暴露。 以及指导高级学员（例如博士后研究员、初级教师）追求的资源 Manuck 博士将利用北卡罗来纳大学的广泛资源来实现这一目标，包括 NIH 资助的中心和培训项目、网络和合作以及全球健康职业机构。 目的和目标：Manuck 博士将实现以下职业发展目标，包括： 目标 1 - 扩展环境健康知识；职业目标 2 - 提高指导技能； 加强传播科学成果的能力 研究计划：Manuck 博士将利用她的 R01 研究。 （目前正在招募）评估暴露于促炎环境污染物的影响 她将整合整个研究目标的指导：目标 1 – 量化曝光。 通过自我报告和对母体尿液、血清、 目标 2 – 确定哪种污染物或污染物组合的相关性最强 目标 3 – 测试基因 x 环境相互作用对复发性 SPTB 风险的影响。 为 Manuck 博士将环境污染物纳入早产儿的培训提供了一个框架 研究表明，美国每年有超过 450,000 名过早分娩的婴儿可能会受到终生影响，而 同时为指导未来致力于以患者为导向的研究的研究人员提供一个平台。

项目成果

OBGYN practice patterns regarding combination therapy for prevention of preterm birth: A national survey.

预防早产联合治疗的妇产科实践模式：一项全国调查。

• 发表时间: 2021-11
• 作者: Booker, Whitney A;Reed, Eda G;Power, Michael L;Schulkin, Jay;Gyamfi;Manuck, Tracy;Berghella, Vincenzo;Vink, Joy
• 通讯作者: Vink, Joy

Identifying Risk Factors for Levels of Per- and Polyfluoroalkyl Substances (PFAS) in the Placenta in a High-Risk Pregnancy Cohort in North Carolina.

确定北卡罗来纳州高风险妊娠队列胎盘中全氟烷基物质和多氟烷基物质 (PFAS) 水平的风险因素。

• 发表时间: 2020
• 影响因子: 11.4
• 作者: Bangma, Jacqueline;Eaves, Lauren A;Oldenburg, Kirsi;Reiner, Jessica L;Manuck, Tracy;Fry, Rebecca C
• 通讯作者: Fry, Rebecca C

Physical activity and pregnancy outcomes: an expert review.

体力活动和妊娠结局：专家评审。

• 发表时间: 2023-01
• 作者: Gascoigne, Emily L;Webster, Carolyn M;Honart, Anne West;Wang, Penny;Smith;Manuck, Tracy A
• 通讯作者: Manuck, Tracy A

Characteristics and Outcomes of Patients With Pregnancy-Related End-Stage Kidney Disease.

妊娠相关终末期肾病患者的特征和结果。

• 发表时间: 2023-12-01
• 影响因子: 13.8
• 作者: Kucirka, Lauren M;Angarita, Ana M;Manuck, Tracy A;Boggess, Kim A;Derebail, Vimal K;Wood, Mollie E;Meyer, Michelle L;Segev, Dorry L;Reynolds, Monica L
• 通讯作者: Reynolds, Monica L

17-hydroxyprogesterone caproate for women with congenital uterine anomalies: does it impact the risk of recurrent preterm birth?

17-羟基孕酮己酸酯用于先天性子宫异常的女性：是否会影响复发性早产的风险？

• 发表时间: 2021
• 作者: Hynes, Jenna S;Schwartz, Amanda R;Abdalla, Azza;Manuck, Tracy A;Dotters
• 通讯作者: Dotters