HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES

高场 MRI 和迷路：前庭刺激和新成像技术

基本信息

批准号：
10542731
负责人：
Bryan Kevin Ward
金额：
$ 19.76万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10542731
关键词：
Address Anatomy Animals Asphyxia Atelectasis Award Biomedical Engineering Chinchilla (genus)Clinical Conscious Curiosities Data Dedications Development Diagnosis Disease Dizziness Edema Endolymph Environment Ethics Functional disorder Funding Future Goals Grant Hair Cells Head Head and Neck Surgery Head and neck structure Health Human Image Imaging Techniques Interdisciplinary Study K-Series Research Career Programs Knowledge Labyrinth Liquid substance MRI Scans Magnetic Resonance Imaging Magnetism Mammals Meniere&apos s Disease Mentors Methods Movement Nausea Nausea and Vomiting Neurology Noise North America Otolaryngology Otology Participant Pathologic Nystagmus Pathology Patients Pattern Performance Phase Physics Physiological Pneumonia Positional Vertigo Positioning Attribute Prospective Studies Protocols documentation Publishing Radiology Specialty Research Research Personnel Resolution Safety Scanning Signal Transduction Structure Supination Surface System Target Populations Techniques Technology Testing Time Training Universities Vertigo Vestibule Work anatomic imaging aspirate career cellular transduction clinical practice clinical training cost cost effective experience fluid flow high resolution imaging human imaging imaging modality improved in vivo inner ear diseases magnetic field medical schools membranous labyrinth nervous system disorder novel professor programs recruit responsible research conduct risk minimization skills temporal measurement vector ward

项目摘要

ABSTRACT Dr. Bryan Ward is an assistant professor in the department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine, where he is dedicating his clinical practice to vestibular disorders, otology and neurotology. He is seeking a mentored career development award in order to fill knowledge gaps in imaging of the inner ear using MRI. His long-term goal is establishing an independent research program that is devoted to using imaging to improve the diagnosis and treatment of patients with dizziness and imbalance. The candidate proposes expanding on his prior work studying the physiologic effects of strong magnetic fields on the inner ear vestibular system to imaging the fluid flow in the labyrinth of healthy chinchillas and humans. The training plan immerses Dr. Ward in the multidisciplinary research and clinical environments in the departments of radiology, neurology, biomedical engineering and otolaryngology at the Johns Hopkins University School of Medicine. Specific training goals include: (1) receive training in the physics of MRI and how images are acquired, (2) complete training in MRI safety and performing prospective studies using imaging modalities, (3) pursue additional training in the ethical and responsible conduct of research, and (4) integrate his clinical training in vestibular disorders with this knowledge as he develops into an independent investigator. High magnetic field MRIs can increase spatial and temporal resolution of images as a result of increased signal-to-noise ratio; however, these MRI machines also cause dizziness and vertigo in humans. We previously showed that all healthy humans have nystagmus in an MRI and hypothesized that this is due to a Lorentz force occurring in the labyrinth. The specific aims of the proposed research are to: (1) test the hypothesis that a Lorentz force causes fluid flow that can be observed in vivo using phase contrast/flow imaging in MRI, (2) to develop and implement a cost-effective countermeasure that minimizes the risk of vertigo in high-strength MRI fields, and (3) to image the human labyrinth in 7T and 3T MRI combining anatomic and flow imaging sequences. The study will involve chinchillas in aim 1 and the recruitment of healthy human participants in aims 2 and 3. Completion of the proposed research plan will provide evidence for the cause of dizziness in strong MRI, a low-cost method to mitigate the effects of dizziness in an MRI regardless of the magnetic field strength, and support that improved MRI can provide higher resolution images of the labyrinth. At the conclusion of this award, the candidate will be well-positioned to compete successfully for funding, having acquired relevant knowledge and skills to become a leader in using high-strength MRI to identify new vestibular pathophysiology and improve diagnosis of common conditions that cause dizziness and vertigo.

抽象的布莱恩·沃德 (Bryan Ward) 博士是伦敦大学耳鼻喉头颈外科系的助理教授约翰霍普金斯大学医学院，他致力于前庭疾病、耳科的临床实践和神经病学。他正在寻求指导性职业发展奖，以填补以下方面的知识空白：使用 MRI 进行内耳成像。他的长期目标是建立一个独立的研究计划致力于利用影像学来改善头晕和失衡患者的诊断和治疗。这候选人建议扩展他之前研究强磁场对人体的生理影响的工作内耳前庭系统对健康龙猫和人类迷宫中的流体流动进行成像。这培训计划让沃德博士沉浸在各部门的多学科研究和临床环境中约翰·霍普金斯大学放射学、神经病学、生物医学工程和耳鼻喉科博士药品。具体培训目标包括： (1) 接受 MRI 物理学以及图像如何形成的培训获得，(2) 完成 MRI 安全性培训并使用成像方式进行前瞻性研究，(3) 寻求道德和负责任的研究行为方面的额外培训，以及（4）整合他的临床当他成长为一名独立调查员时，他接受了有关前庭疾病的培训，并掌握了这些知识。高磁场 MRI 可以通过增加图像的空间和时间分辨率来提高图像的空间和时间分辨率。信噪比；然而，这些核磁共振仪也会导致人类头晕和眩晕。我们之前的研究表明，所有健康的人都会在 MRI 中出现眼球震颤，并推测这是由于迷宫中发生洛伦兹力。本研究的具体目标是：（1）测试洛伦兹力引起流体流动的假设，可以使用相差/流动在体内观察到 MRI 成像，(2) 制定并实施具有成本效益的对策，最大限度地降低眩晕风险 (3) 在 7T 和 3T MRI 中结合解剖学对人体迷路进行成像和血流成像序列。该研究将在目标 1 中涉及龙猫，并招募健康人类目标 2 和 3 的参与者。完成拟议的研究计划将为以下原因提供证据强 MRI 中的头晕，一种减轻 MRI 中头晕影响的低成本方法，无论其效果如何磁场强度，并支持改进的 MRI 可以提供更高分辨率的迷宫图像。在该奖项结束时，候选人将处于有利地位，能够成功竞争资金，已获得相关知识和技能，成为使用高强度 MRI 识别新事物的领导者前庭病理生理学并提高对引起头晕和眩晕的常见病症的诊断。