Segmenting Brain Structures for Neurological Disorders

分割神经系统疾病的大脑结构

• 批准号: 10527314
• 负责人: Bruce Fischl
• 金额: $ 49.56万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527314
• 关键词: Affect; Aging; Algorithmic Analysis; Algorithms; Alzheimer' s Disease; Anatomy; Atlases; Brain; Brain Stem; Cell Nucleus; Chemicals; Claustral structure; Code; Coma; Consciousness Disorders; Data; Data Set; Diagnosis; Diffusion; Disease; Disparate; Documentation; Ensure; Future; Generations; Globus Pallidus; Habenula; Histologic; Histology; Human; Image; Image Analysis; Image Enhancement; Infrastructure; Label; Licensing; Location; MRI Scans; Magnetic Resonance Imaging; Manuals; Methods; Modeling; Neuroanatomy; Neurobiology; Parkinson Disease; Phase; Phase III Clinical Trials; Physiology; Population; Procedures; Protocols documentation; Publishing; Qualifying; Red nucleus structure; Reproducibility; Research; Research Design; Research Personnel; Resolution; Resources; Rest; Scanning; Source; Speed; Staging; Stress; Structure; Structure of subthalamic nucleus; Substantia nigra structure; System; Techniques; Technology; Test Result; Testing; Thalamic Nuclei; Therapeutic Intervention; Validation; Ventral Tegmental Area; Visualization; Visualization software; Work; algorithm development; automated segmentation; base; capsule; data acquisition; design; efficacy evaluation; ex vivo imaging; flexibility; histological image; human disease; imaging Segmentation; in vivo; interest; morphometry; nervous system disorder; open source; open source tool; power analysis; segmentation algorithm; skills; support tools; targeted treatment; tool; tractography; ultra high resolution; usability; web site; wiki

Abstract Magnetic Resonance Imaging (MRI) is a flexible and powerful technology for quantifying the effects of many conditions, including numerous neurological disorders, on human brain anatomy, connectivity, vasculature, chemical composition, physiology and function. In the past 15 years, several open source tools have been developed that accurately and automatically segment an array of brain structures. In this project, we seek the resources to extend this set to enable the quantification of neuroanatomical changes that are critical to diagnosing, staging and assessing the efficacy of potential therapeutic interventions in diseases such as Alzheimer’s and Parkinson’s. This includes the acquisition of datasets to enable manual labeling of structures of interest, the generation of documentation, tutorials, unit tests, regression tests and system tests to harden the tools and make them usable by clinicians and neuroscientists, and finally the distribution and support of the data, manual labelings and tools to the more than 32,000 researchers that use FreeSurfer through our existing open source mechanism.

抽象的 磁共振成像 (MRI) 是一种灵活而强大的技术，用于量化许多因素的影响 条件，包括许多神经系统疾病，对人脑解剖学、连通性、脉管系统、 在过去的 15 年里，出现了一些开源工具。 开发出能够准确自动分割一系列大脑结构的技术。在这个项目中，我们寻求 扩展此集的资源，以实现对神经解剖学变化至关重要的量化 诊断、分期和评估潜在治疗干预措施的功效，例如 阿尔茨海默氏症和帕金森氏症包括获取数据集以实现结构的手动标记。 感兴趣的是生成文档、教程、单元测试、回归测试和系统测试来强化 工具并使其可供大众和神经科学家使用，最后是分发和支持 通过我们现有的方式向使用 FreeSurfer 的 32,000 多名研究人员提供数据、手动标签和工具 开源机制。

项目成果

An open-source tool for longitudinal whole-brain and white matter lesion segmentation.

用于纵向全脑和白质病变分割的开源工具。

• 发表时间: 2023
• 作者: Cerri, Stefano;Greve, Douglas N;Hoopes, Andrew;Lundell, Henrik;Siebner, Hartwig R;Mühlau, Mark;Van Leemput, Koen
• 通讯作者: Van Leemput, Koen

MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.

MarkVCID脑小血管联盟：II。

• 发表时间: 2021-04
• 作者: Lu, Hanzhang;Kashani, Amir H;Arfanakis, Konstantinos;Caprihan, Arvind;DeCarli, Charles;Gold, Brian T;Li, Yang;Maillard, Pauline;Satizabal, Claudia L;Stables, Lara;Wang, Danny J J;Corriveau, Roderick A;Singh, Herpreet;Smith, Eric E;Fischl, Br
• 通讯作者: Fischl, Br

Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement.

多发性硬化症中的深部灰质损伤：NAIMS 共识声明。

• 发表时间: 2021
• 作者: Ontaneda, Daniel;Raza, Praneeta C;Mahajan, Kedar R;Arnold, Douglas L;Dwyer, Michael G;Gauthier, Susan A;Greve, Douglas N;Harrison, Daniel M;Henry, Roland G;Li, David K B;Mainero, Caterina;Moore, Wayne;Narayanan, Sridar;Oh, Jiwon;Patel, Raiha
• 通讯作者: Patel, Raiha

A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors.

人脑 GABAA 受体苯二氮卓结合位点的高分辨率体内图谱。

• 发表时间: 2021
• 影响因子: 5.7
• 作者: Nørgaard, Martin;Beliveau, Vincent;Ganz, Melanie;Svarer, Claus;Pinborg, Lars H;Keller, Sune H;Jensen, Peter S;Greve, Douglas N;Knudsen, Gitte M
• 通讯作者: Knudsen, Gitte M

Serial Reaction Time Task Performance in Older Adults with Neuropsychologically Defined Mild Cognitive Impairment.

患有神经心理学定义的轻度认知障碍的老年人的串行反应时间任务表现。

• DOI: 10.3233/jad-191323
• 发表时间: 2020
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Hong, Yue;Alvarado, Rachel L.;Jog, Amod;Greve, Douglas N.;Salat, David H.
• 通讯作者: Salat, David H.