Rerunning the evolution of an ancient bacterial propeller

重新运行古代细菌螺旋桨的进化

• 批准号: DP240100462
• 负责人: A/Prof Matthew Baker
• 金额: $ 42.74万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-10-01 至 2027-09-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100462
• 关键词: Rerunning; evolution; ancient; bacterial; propeller

This project aims to measure how the propeller which drives bacterial swimming originated and then evolved. This project expects to generate new knowledge in molecular evolution using interdisciplinary techniques in synthetic biology and biophysics to resurrect ancient proteins and test how they can be directed to evolve in a contemporary host. Expected outcomes include the development of new types of flagellar motor for applied uses in synbio and microfluidics, and new methods to resurrect ancient proteins and evolve their function for purpose. This should provide significant benefits by delivering a de novo molecular motor for custom applications and galvanise public interest in how this iconic molecular complex originated and evolved.

该项目旨在衡量如何驱动细菌游泳的螺旋桨产生然后进化。该项目希望使用合成生物学和生物物理学中的跨学科技术在分子进化方面产生新知识，以复活古代蛋白质并测试如何在当代宿主中进行进化。预期的结果包括开发用于Synbio和Microfluidics中应用的新型鞭毛电动机，以及复活古代蛋白质并为目的而发展其功能的新方法。这应该通过为自定义应用提供从头分子电机，并使公众对这种标志性分子复合物的产生和演变的方式促进公众兴趣来提供重大的好处。