Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans

老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素

• 批准号: 10516954
• 负责人: MARK A GLUCK
• 金额: $ 34.45万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516954
• 关键词: Address; Administrative Supplement; Aerobic Exercise; Africa; African; African American; African American population; African ancestry; Age; Alzheimer' s Disease; Alzheimer' s disease risk; American; Behavioral; Blood; Candidate Disease Gene; Cognition; Cognitive; Comparative Study; Complex; Cross-Sectional Studies; Data Collection; Disease Outcome; Disease Progression; Education; Elderly; Epidemiology; Funding; Future; Gender; Genetic; Genetic Variation; Goals; Grant; Health; Health Alliance; Impaired cognition; Individual Differences; Knowledge; Lead; Life Style; Link; Medial; Mediating; Medical; Methods; Neurologist; Nigeria; Nigerian; Patient Recruitments; Patient Self-Report; Persons; Physical Fitness; Plant Roots; Population; Postdoctoral Fellow; Publishing; Race; Research Personnel; Risk; Risk Factors; Risk Marker; Site; Slave; Sleep; Temporal Lobe; United States National Institutes of Health; Universities; Validation; Variant; Work; aging brain; cognitive function; cognitive testing; cohort; comparative; data preservation; improved; innovation; lifestyle factors; longitudinal analysis; multidisciplinary; non-demented; nonEnglish language; novel; parent grant; physical therapist; prodromal Alzheimer' s disease; recruit; relating to nervous system; risk variant

PROJECT SUMMARY/ABSTRACT We seek to compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments of generalization developed at Rutgers, while linking individual differences in cognitive function on these tasks to variations in candidate genes. A majority of African American descendants of slaves have their ancestry (and hence, genetic variations) linked to the Yoruba people of West Africa. Understanding the similarities and differences in the interactions between genetic and lifestyle variations influencing MTL-specific cognition in older African Americans and older Yoruba will further illuminate complex determinants of AD risk and progression. This one year administrative supplement seeks to cross-validate current findings on risks of Alzheimer’s disease (AD) in African Americans with a different but similar and related population cohort—Yoruba people of West Africa by addressing a key question: Are African Americans and Yoruba people similar in their behavioral and neural risk markers for AD, specifically with regard to interactions between genetics (especially APOE and ABCA7) and modifiable health and lifestyle factors, especially physical fitness. With this supplemental funding we will expand the parent grant methods to collect blood from (a) 120 cognitively-healthy (non-demented) Yoruba, ages 60 and above, recruited at the University of Ibadan, and (b) compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments developed at Rutgers. The initial cross-sectional analysis will compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments of generalization developed at Rutgers, while linking individual differences in cognitive function on these tasks to variations in candidate genes. This will lead up to the longitudinal analysis (R01) assessing broader root causes of the high rates of cognitive decline and AD progression in older people of African ancestry.

项目概要/摘要 我们试图比较非裔美国人和尼日利亚约鲁巴人之间的遗传/生活方式相互作用， 使用罗格斯大学开发的新颖的泛化认知评估，同时将个体差异联系起来 这些任务的认知功能与候选基因的变异有关。 奴隶的后裔的祖先（因此也有遗传变异）与西方约鲁巴人有关 非洲。了解遗传与生活方式之间相互作用的异同。 影响年长非裔美国人和年长约鲁巴人 MTL 特定认知的差异将进一步阐明 AD 风险和进展的复杂决定因素。 这项为期一年的行政补充旨在交叉验证当前关于阿尔茨海默病风险的发现 与不同但相似且相关的人群——约鲁巴人——非裔美国人中的疾病（AD） 西非通过解决一个关键问题：非裔美国人和约鲁巴人的行为是否相似 AD 的神经风险标记，特别是遗传因素之间的相互作用（尤其是 APOE 和 ABCA7) 以及可改变的健康和生活方式因素，尤其是身体健康。 有了这笔补充资金，我们将扩大家长补助金的方法，以从 (a) 120 认知健康（非痴呆）约鲁巴人，年龄 60 岁及以上，在伊巴丹大学招募，以及 (b) 使用新的认知方法比较非裔美国人和尼日利亚约鲁巴人之间的遗传/生活方式相互作用 罗格斯大学开发的评估最初的横断面分析将比较遗传/生活方式。 非裔美国人和尼日利亚约鲁巴人之间的互动，使用新颖的认知评估 罗格斯大学发展了泛化，同时将这些任务的认知功能的个体差异与 这将导致纵向分析（R01）评估更广泛的根。 非洲血统老年人认知能力下降和 AD 进展率高的原因。