Can neural network instability in schizophrenia be improved with a very low carbohydrate ketogenic diet?

精神分裂症的神经网络不稳定可以通过极低碳水化合物的生酮饮食来改善吗？

基本信息

批准号：
10517239
负责人：
Judith M Ford
金额：
$ 5.97万
依托单位：
NORTHERN CALIFORNIA INSTITUTE/RES/EDU
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10517239
关键词：
Acute Adult Age Aging Anhedonia Antipsychotic Agents Body Weight decreased Brain Carbohydrates Chronic Clinical Clinical Research Cognition Cognitive deficits Data Delusions Diagnosis Diet Disease Doctor of Philosophy Eating Educational Curriculum Educational workshop Fatty acid glycerol esters Functional Magnetic Resonance Imaging Functional disorder Glucose Goals Grant Hallucinations Homeostasis Impaired cognition Inflammation Inflammatory Insulin Insulin Resistance Intervention Interview Ketone Bodies Ketones Ketosis Learning Link Lipids Literature Magnetic Resonance Imaging Measures Mediating Mentors Meta-Analysis Metabolic Metabolic Diseases Metabolic syndrome Metabolism Mitochondria Modernization Neurobiology Neurocognitive Deficit Neuropsychology Non-Insulin-Dependent Diabetes Mellitus Nutrient Obesity Occupational Outcome Overweight Paper Participant Patients Peripheral Persons Pharmaceutical Preparations Predisposition Production Randomized Reactive Oxygen Species Reducing diet Reporting Research Rest Risk Role Schizophrenia Symptoms Time Training Visceral fat Weight Gain Work Writing base blood glucose regulation brain dysfunction career development comorbidity deprivation diagnostic criteria experience first episode schizophrenia functional decline glucose metabolism human old age (65+)improved indexing insulin sensitivity ketogenic diet neural network parent grant prevent programs prospective relating to nervous system sex social symptomatic improvement systemic inflammatory response tool

项目摘要

PROJECT SUMMARY/ABSTRACT This diversity supplement will significantly enhance the research potential of Ms. Zanib Naeem and make her competitive for top-tier PhD programs. Ms. Naeem will be involved in a team project that focuses on the benefits of a ketogenic diet in overweight people with schizophrenia. She will become familiar with an array of tools we use in our studies of the pathophysiology of schizophrenia: structural and functional MRI, neuropsychology, and clinical interviews. She will also participate in the Post-Bac Program for Equity and Learning (PROPEL) curriculum activities, on which the PI (Dr. Ford) serves as a mentor. Through the PROPEL program, Ms. Naeem will both participate in biomedical seminars and have access to career development opportunities, such as grant writing workshops and mock interviews.

项目概要/摘要这种多样性补充将显着增强 Zanib Naeem 女士的研究潜力并使她在顶级博士课程中具有竞争力。 Naeem女士将加入一个团队该项目重点关注生酮饮食对超重精神分裂症患者的益处。她将熟悉我们在病理生理学研究中使用的一系列工具。精神分裂症：结构和功能 MRI、神经心理学和临床访谈。她会还参加学士后公平与学习计划 (PROPEL) 课程 PI（福特博士）担任导师的活动。通过 PROPEL 计划， Naeem 将参加生物医学研讨会并获得职业发展机会机会，例如资助写作研讨会和模拟面试。