Einstein Postbaccalaureate Research Education Program

爱因斯坦学士后研究教育计划

• 批准号: 10516330
• 负责人: Myles H. Akabas
• 金额: $ 41.16万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516330
• 关键词: Active Learning; American; Biomedical Research; Communication; Creativeness; Development Plans; Doctor of Philosophy; Educational process of instructing; Enrollment; Faculty; Goals; Health; Individual; Interdisciplinary Study; Interview; Journals; Knowledge; Laboratory Research; Mentors; Oral; Population; Postbaccalaureate; Process; Recording of previous events; Research; Research Project Grants; Running; Scientist; System; Underrepresented Minority; United States; Universities; Work; Writing; career; design; disabled students; doctoral student; education research; ethnic diversity; experience; improved; matriculation; medical schools; minority scientist; peer coaching; programs; racial diversity; skills; social; success; support network; undergraduate student; underrepresented minority student

Project Summary/Abstract Neither the biomedical research workforce nor the faculty at research universities and medical schools reflect the racial and ethnic diversity of the American population. In part, this is due to the limited number of underrepresented minority (URM) students who enter PhD and MD-PhD programs. Lack of substantive research experiences during undergraduate studies leaves many URM students unprepared to apply to competitive graduate programs. The goal of this Post-Baccalaureate Research Education Program (PREP) is to provide URM and disabled students, who want to pursue a career in biomedical research, with the intensive research experience and academic enrichment necessary to make them competitive applicants to rigorous PhD and MD-PhD programs. Einstein has a long history of successfully mentoring URM students through both its PhD and MD-PhD programs. The Einstein PREP has four major components designed to prepare trainees to apply successfully to PhD or MD-PhD programs: 1) an intensive, mentored laboratory research experience, 2) a didactic component to increase trainees' scientific knowledge and prepare them for interdisciplinary research, 3) an oral and written communications skills enhancement program, and 4) a layered mentoring system to provide the trainees with the support network they need to flourish in the program and beyond. These four components are interwoven throughout the year long program. The program begins with a two week Orientation during which trainees select their research mentor. The mentored research project emphasizes the process of hypothesis-based research, the excitement and joy of scientific discovery, and the persistence and creativity needed to achieve success. Trainees work with the Program Directors and research mentor to formulate an Individual Development Plan. Each trainee is assigned either a URM PhD or MD-PhD student peer mentor. The Einstein Minority Scientist Association will run a monthly PREP Journal Club and other social and scientific activities. The Program Directors will meet with the trainees on a weekly basis for informal and didactic sessions. This combination of didactic and experiential learning will prepare the applicants to apply successfully to highly competitive PhD and MD-PhD programs. We expect that more than 75% of our trainees will matriculate and successfully complete such programs. To date, 19 trainees have entered the program, 12 have completed and all are enrolled in PhD or MD-PhD programs, i.e., 100% success. Of the 7 trainees currently in the program, one applying to MD-PhD programs already has an acceptance; five applying to PhD programs already have multiple interview invitations. We expect that all will successfully matriculate into graduate programs. The seventh trainee will spend a second year in the program while she applies to MD-PhD programs. Our PREP alumni will ultimately expand the US biomedical workforce diversity.

项目概要/摘要 无论是生物医学研究人员还是研究型大学和医学院的教员 反映了美国人口的种族和民族多样性。部分原因是由于数量有限 进入博士和医学博士-博士课程的代表性不足的少数族裔 (URM) 学生。缺乏实质性内容 本科学习期间的研究经历让许多 URM 学生没有准备好申请 有竞争力的研究生课程。学士后研究教育计划 (PREP) 的目标是 为想要从事生物医学研究职业的 URM 和残疾学生提供强化课程 研究经验和学术丰富是使他们成为有竞争力的申请者所必需的 博士和医学博士-博士课程。爱因斯坦在通过以下两种方式成功指导 URM 学生方面有着悠久的历史： 其博士和医学博士-博士课程。 Einstein PREP 有四个主要组成部分，旨在帮助学员做好准备 成功申请博士或医学博士-博士课程：1) 密集的、受指导的实验室研究经验， 2）教学部分，以增加受训者的科学知识并为跨学科做好准备 研究，3) 口头和书面沟通技能增强计划，以及 4) 分层指导 系统为学员提供他们在项目内外蓬勃发展所需的支持网络。 这四个部分在整个全年计划中相互交织。该程序以两个开始 周 培训期间，学员选择他们的研究导师。指导的研究项目 强调基于假设的研究过程、科学发现的兴奋和喜悦以及 取得成功需要毅力和创造力。学员与项目总监一起工作并进行研究 导师制定个人发展计划。每个学员都会被分配一个 URM 博士或 MD-PhD 学生同伴导师。爱因斯坦少数派科学家协会将每月举办一次 PREP 期刊俱乐部， 其他社会和科学活动。项目主管将每周与学员会面，讨论 非正式和教学会议。这种教学和体验式学习的结合将为 申请人成功申请竞争激烈的博士和医学博士项目。我们预计超过 我们 75% 的学员将入学并成功完成此类课程。截至目前，已有19名学员 进入该项目后，12 人已完成，并且全部进入博士或医学博士-博士项目，即 100% 成功。 目前该项目的 7 名学员中，一名申请 MD-PhD 项目的学员已获得录取；五 申请博士课程已经有多个面试邀请。我们期望一切都会成功 入读研究生课程。第七名学员将在该计划中度过第二年，而她 适用于医学博士-博士课程。我们的 PREP 校友最终将扩大美国生物医学劳动力的多样性。

项目成果

Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells.

蛋白质变性和酶抑制剂对人胚肾细胞中蛋白酶体介导的肽生产的影响。

• 发表时间: 2019
• 影响因子: 5.5
• 作者: Dasgupta, Sayani;Fishman, Michael A;Castro, Leandro M;Tashima, Alexandre K;Ferro, Emer S;Fricker, Lloyd D
• 通讯作者: Fricker, Lloyd D