Functional Outcomes of Cannabis Use (FOCUS) in Veterans withPosttraumatic Stress Disorder

患有创伤后应激障碍的退伍军人使用大麻（FOCUS）的功能结果

• 批准号: 10508499
• 负责人: JEAN C. BECKHAM
• 金额: --
• 依托单位: DURHAM VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10508499
• 关键词: Address; Affect; Cannabis; Data; Distress; Ecological momentary assessment; Education; Feeling suicidal; Frequencies; Healthcare; Illicit Drugs; Laboratories; Legal; Light; Medical Marijuana; Mental Depression; Mental Health; Mental disorders; Methods; Monitor; Neuropsychology; Patients; Post-Traumatic Stress Disorders; Prospective Studies; Psychoses; Quality of life; Recovery of Function; Reporting; Research; Risk; Short-Term Memory; Substance abuse problem; Testing; Time; Traffic accidents; Unemployment; Veterans; community reintegration; comorbidity; contingency management; daily functioning; drugged driving; executive function; functional outcomes; improved; innovation; interest; marijuana use; marijuana use disorder; marijuana user; non-suicidal self injury; psychosocial; randomized, clinical trials; secondary outcome; stress disorder; suicidal; symptomatology

Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that affects 20%-30% of U.S. Veterans. PTSD is strongly associated with increased risk for substance abuse comorbidity, including cannabis use disorder; however, multiple states now include PTSD as a condition for which patients can be legally prescribed medical marijuana, despite the fact that there has not been a single large-scale randomized clinical trial demonstrating the efficacy of cannabis to treat PTSD to date. The overall objective of the current proposal is to prospectively study the impact of reduced cannabis use on psychosocial functioning among Veterans with PTSD. To do so, we will first use ecological momentary assessment (EMA) methods to evaluate the relationship between cannabis use and daily functioning among Veterans with PTSD. Next, we will use mobile contingency management (CM) and EMA to assess the impact of reduced cannabis use on daily functioning among Veterans with PTSD who are heavy cannabis users. Our central hypothesis is that reductions in cannabis use will lead to positive changes in the functional outcomes of Veterans. The rationale for this research is that it will provide the first and only real-time data concerning the impact of reduced cannabis use on daily functioning among Veterans with PTSD. As a result, this innovative and timely project has the potential to significantly advance VHA healthcare and will directly inform the ongoing national debate concerning the impact of cannabis use on the long-term functional recovery of Veterans with PTSD.

创伤后应激障碍 (PTSD) 是一种致残性精神疾病，影响着 20%-30% 的美国人口。 退伍军人。创伤后应激障碍 (PTSD) 与药物滥用合并症（包括大麻）风险增加密切相关 使用障碍；然而，现在多个州将创伤后应激障碍 (PTSD) 列为患者可以合法治疗的一种病症。 处方药用大麻，尽管事实上还没有一个大规模的随机临床试验 迄今为止，证明大麻治疗创伤后应激障碍（PTSD）功效的试验。当前提案的总体目标 的目的是前瞻性研究减少大麻使用对退伍军人心理社会功能的影响 创伤后应激障碍。为此，我们首先使用生态瞬时评估（EMA）方法来评估 患有创伤后应激障碍 (PTSD) 的退伍军人中大麻使用与日常功能之间的关系。接下来我们将使用手机 应急管理 (CM) 和 EMA 评估减少大麻使用对日常功能的影响 患有创伤后应激障碍 (PTSD) 的退伍军人是大麻的重度使用者。我们的中心假设是减少 大麻的使用将导致退伍军人的功能结果发生积极变化。这样做的理由 研究表明，它将提供第一个也是唯一一个有关减少大麻使用影响的实时数据 患有创伤后应激障碍 (PTSD) 的退伍军人的日常运作。因此，这个创新且及时的项目具有潜力 显着推进 VHA 医疗保健，并将直接为正在进行的有关 VHA 的全国性辩论提供信息 使用大麻对患有创伤后应激障碍 (PTSD) 退伍军人的长期功能恢复的影响。