MRI-compatible BrainPET Scanner

兼容 MRI 的 BrainPET 扫描仪

• 批准号: 10505319
• 负责人: Ciprian Catana
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10505319
• 关键词: 15 year old; AIDS/HIV problem; Accounting; Address; Aging; Agreement; Anxiety Disorders; Award; Bipolar Disorder; Boston; Brain; Communities; Development; Devices; Failure; Funding; Goals; Head; Human; Leadership; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Mental Depression; Mental Health; Mental disorders; Methods; Modality; National Institute of Mental Health; Neurosciences; Performance; Positron-Emission Tomography; Price; Radiochemistry; Radiology Specialty; Research; Research Personnel; Schedule; Schizophrenia; Services; System; Technology; United States National Institutes of Health; autism spectrum disorder; data acquisition; detector; healthy volunteer; human subject; imaging modality; improved; instrument; nervous system disorder; nonhuman primate; patient population; programs; prototype; research study; substance use; traumatic event

Project Summary/Abstract This application seeks support from NIMH to purchase the 3-Tesla magnetic resonance (MR)-compatible positron emission tomography (PET) brain scanner manufactured by Cubresa, Inc. PET and MRI are two of the most powerful imaging modalities currently in use for studying the human brain. Scanners capable of simultaneous PET and MR whole-body data acquisition in human subjects became commercially available a decade ago. However, until recently, there was no equivalent dedicated head device on the market to address the needs of the researchers and clinicians focusing on the brain and the performance of whole-body devices is rather limited for this purpose. A high-performance MR-compatible BrainPET scanner installed at the Martinos Center would benefit many brain-focused research studies in our center and in the community. The Cubresa BrainPET would replace the Siemens BrainPET prototype that was installed at the Martinos Center in May 2008 and has served our investigators effectively for more than a decade. It was moved in the Martinos Center PET & Radiochemistry Facility in June 2011 and became the workhorse of our PET program for many years even after the installation of the Biograph mMR. At peak usage, three-dozen projects were using the BrainPET prototype in a variety of studies ranging from those aimed at characterizing the scanner performance, developing methods to use the information obtained from one device to improve the other modality, and demonstrating the tremendous potential of this technology through proof-of-principle studies in non-human primates, healthy volunteers, and numerous patient populations. However, with the exceedingly fast PET detector developments seen in the last decade, the 15+ year old technology has now become outdated. The service agreement for the BrainPET prototype ended 5 years ago and the prototype has been non-functional for about a third of 2021 due to technical failures. Therefore, a replacement of this aging and obsolete system will be necessary to enhance and complete the scientific goals and aims of the ongoing projects focused on several mental disorders and related topics (i.e., anxiety disorders, autism spectrum disorder, bipolar disorder, depression, HIV/AIDS and mental health, schizophrenia, substance use, traumatic events) as well as on neurological diseases and basic neuroscience. The installation of the new instrument is being supported by the MGH leadership, Radiology Department, and Martinos Center. This multi-level institutional support covers allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, and lastly, a commitment of up to $278,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed funds of $100,000 from the MGH Executive Committee for Research. Following the installation, the Cubresa BrainPET will be managed by the Martinos Center as a shared core, and made available to the broader research community, both within MGH and the Greater Boston region.

项目概要/摘要 本申请寻求 NIMH 支持购买 3-Tesla 磁共振 (MR) 兼容 由 Cubresa, Inc. 制造的正电子发射断层扫描 (PET) 脑部扫描仪。PET 和 MRI 是其中两种 目前用于研究人脑的最强大的成像方式。扫描仪能够 同步 PET 和 MR 人体全身数据采集已商业化 十年前。然而，直到最近，市场上还没有同等的专用头设备来解决 研究人员和临床医生对大脑和全身设备性能的需求是 对于这个目的来说相当有限。安装在 Martinos 的高性能 MR 兼容 BrainPET 扫描仪 中心将使我们中心和社区的许多以大脑为中心的研究受益。库布雷萨 BrainPET 将取代 2008 年 5 月安装在马蒂诺斯中心的西门子 BrainPET 原型 十多年来一直有效地为我们的调查人员提供服务。它被移至马蒂诺斯中心 PET 和放射化学设施于 2011 年 6 月成为我们 PET 项目的主力，甚至多年 安装 Biograph mMR 后。在使用高峰期，有三打项目正在使用 BrainPET 各种研究中的原型，包括旨在表征扫描仪性能的研究、开发 方法使用从一个设备获得的信息来改进另一种模式，并演示 通过对非人类灵长类动物、健康动物的原理验证研究，该技术的巨大潜力 志愿者和众多患者群体。然而，随着 PET 探测器的快速发展 从过去十年来看，已有 15 年以上历史的技术现在已经过时了。服务协议为 BrainPET 原型机已于 5 年前结束，由于该原型机在 2021 年约三分之一的时间里都无法发挥作用 到技术故障。因此，有必要更换这种老化和过时的系统，以增强 并完成正在进行的项目的科学目标和目的，重点关注几种精神障碍和 相关主题（即焦虑症、自闭症谱系障碍、双向情感障碍、抑郁症、艾滋病毒/艾滋病和 心理健康、精神分裂症、药物滥用、创伤事件）以及神经系统疾病和基础知识 神经科学。新仪器的安装得到了麻省总医院放射科领导层的支持 部门和马蒂诺斯中心。这种多层次的机构支持涵盖仪器空间的分配和 安装协助、系统调度、会计和维护方面的操作支持，以及 最后，承诺提供高达 278,000 美元的资金，以弥补 NIH SIG 奖项与购买价格之间的差距 除了 MGH 执行委员会承诺的 100,000 美元资金外，还用于升级 研究。安装完成后，Cubresa BrainPET 将由 Martinos 中心作为共享中心进行管理 核心，并提供给麻省总医院和大波士顿地区更广泛的研究界。