Administrative Core

行政核心

• 批准号: 10505612
• 负责人: MARGIE L. CLAPPER
• 金额: $ 25.89万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505612
• 关键词: Attention; Biological; Collaborations; Communication; Communities; Consultations; Data; Educational workshop; Ensure; Evaluation; Fox Chase Cancer Center; Goals; Hereditary Neoplastic Syndromes; Informatics; Infrastructure; Intercept; Interdisciplinary Study; Laboratory Research; Leadership; Malignant Neoplasms; Molecular Target; Monitor; Prevention; Productivity; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Technical Expertise; Validation; cancer prevention; conflict resolution; data resource; efficacy testing; in vivo; meetings; member; multidisciplinary; pre-clinical; precision cancer prevention; programs; screening; skills; success; targeted agent

PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core will provide the infrastructure required to ensure efficient coordination, integration, planning, and evaluation of all agent discovery activities associated with the proposed CAP-IT Center. The Core provides an integrated multidisciplinary framework for scientific collaboration among the participating members and Shared Resources at FCCC. To facilitate productivity, the Administrative Core will provide fiscal management and clerical support, as well as ensure scientific rigor, data reproducibility, attention to important biological variables, transparency, and consistent communication. Importantly, the Administrative Core will serve as a liaison with the NCI and other Specialized CAP-IT Centers, and leverage the support of the Informatics Core to effectively engage with the Data and Resource Coordinating Center. Active participation of CAP-IT members in meetings, workshops and activities of the CAP-IT Network will be coordinated through the Administrative Core. These activities will be accomplished according to four specific aims to: 1) Maintain an effective framework of well-integrated multidisciplinary research activities by applying strong communication and organizational skills, and frequently monitoring research progress; 2) Promote trans-Network collaborations by coordinating and participating in CAP-IT Network meetings, and organizing inter-programmatic seminars and workshops; 3) Engage early-stage investigators in precision cancer prevention – interception research and disseminate findings and capabilities to the scientific community; and 4) Evaluate the progress of the proposed CAP-IT Center using standard deliverables and defined metrics and milestones of success. The Leadership Team, comprised of accomplished investigators with expertise in hereditary cancer syndromes, target validation, agent screening, in vivo efficacy testing, and informatics, will provide oversight of all aspects of the research projects, and make informed decisions at critical junctures of the discovery pipeline. In close consultation with the NCI, the FCCC CAP-IT will leverage its unique resources and technical expertise to fuel the discovery of agents for cancer prevention and interception within the CAP-IT Network and beyond.

项目摘要 - 行政核心 行政核心将提供确保有效协调、整合、 规划和评估与拟议的 CAP-IT 中心相关的所有代理发现活动。 为参与成员之间的科学合作提供综合的多学科框架 FCCC 的共享资源 为了提高生产力，行政核心将提供财政支持。 管理和文书支持，并确保科学严谨性、数据可重复性、对重要问题的关注 重要的是，行政核心将服务于生物变量、透明度和一致的沟通。 作为 NCI 和其他专业 CAP-IT 中心的联络人，并利用信息学的支持 有效参与数据和资源协调中心的核心 CAP-IT 的积极参与。 参加 CAP-IT 网络会议、研讨会和活动的成员将通过 行政核心。这些活动将根据四个具体目标来完成： 1) 维持 通过应用强有力的沟通和交流，建立良好整合的多学科研究活动的有效框架 组织技能，并经常监控研究进展； 2) 促进跨网络合作； 协调和参加 CAP-IT 网络会议，组织跨项目研讨会和 研讨会；3) 让早期研究人员参与精准癌症预防——拦截研究和 向科学界传播研究结果和能力；以及 4) 评估拟议项目的进展情况； CAP-IT 中心使用标准可交付成果以及定义的成功指标和里程碑。 团队由在遗传性癌症综合征、目标验证、 药物筛选、体内功效测试和信息学将为研究的各个方面提供监督 项目，并在发现管道的关键时刻与密切协商做出明智的决策。 NCI、FCCC CAP-IT 将利用其独特的资源和技术专长来推动发现 CAP-IT 网络内外的癌症预防和拦截药物。