Core A Administrative Core

核心 A 行政核心

基本信息

批准号：
10494655
负责人：
GEORGE F MURPHY
金额：
$ 19.51万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2027-05-31
项目状态：
未结题

项目摘要

SUMMARY The Administrative Core (Core A) is an essential core that will organize, coordinate, and oversee, and support the three Projects, and the other two Cores of this PPG. The Core is co-led by George F. Murphy, MD, and Markus H. Frank, MD, whose collaborative history, complementary expertise, and delegation of Core A responsibilities are in keeping with the multi-PI infrastructure of this PPG. In addition to the institutional resources and administrative support structures available to Drs. Murphy and Frank through BWH and BCH, respectively. The overarching goals of the Core are summarized in the categories of i) communication and data sharing; ii) oversight and guidance; and iii) administrative support, and may be briefly described as follows: 1) Implement and oversee a web-based mechanism for data sharing. This relates to the establishment and maintenance of a web-based, secure site for data sharing consisting of three complementary layers of DropBox, Harvard Dataverse and Basecamp, that permit secure access from any location or device with internet capabilities. In addition, it recognizes the ongoing responsibility of Core A CL’s to regularly monitor data accrual and overall PPG progress in a manner that data is rapidly and efficiently shared with the scientific community through web-based technology and an ongoing commitment to publish appropriate findings in open-access journals, or by utilizing public relations resources at the participating institutions for data sharing with the lay public. 2) Monitor and maximize Project progress, inter-Project/Core synergies, and Core utilization. This includes the creation of mutually-agreed upon milestones to be achieved among Projects and Cores, their centralized monitoring, and maintenance of a continuous feedback loop involving Projects/Cores and Core A to maximize project momentum, intercept and address any problems that may inhibit or delay progress, monitor aspects related to reproducibility, and insure that appropriate deliverables are attained in a focused manner that insures translational relevance and eventual clinical application. This aim is structured on regular (monthly) scheduled interactions involving all Project and Core leads during which progress may be assessed and maximized. 3) Provide general administrative support for the PPG. This includes a) the scheduling of monthly meetings; b) establishment and orchestration of periodic meetings with an External Advisory Board (EAB) to review progress and assist in planning; c) conflict mediation and resolution; d) preparation of non-competitive renewal applications and progress reports; e) budgetary management; f) coordination and facilitation of institutional approvals; g) manuscript submission to PubMed Central; and management of new intellectual property created from the grant, including preparation and filing of new invention disclosures to OTD).

概括行政核心（核心 A）是组织、协调、监督和支持的重要核心这三个项目以及该 PPG 的另外两个核心项目由医学博士 George F. Murphy 共同领导。 Markus H. Frank 医学博士，其合作历史、互补的专业知识和核心 A 的授权除了机构资源之外，职责还与该 PPG 的多 PI 基础设施保持一致。墨菲博士和弗兰克博士分别通过 BWH 和 BCH 获得行政支持结构。核心的总体目标概括为以下类别：i) 通信和数据共享；监督和指导；以及 iii) 行政支持，可简要描述如下： 1) 实施和监督基于网络的数据共享机制。维护一个基于网络的安全数据共享站点，该站点由 DropBox 的三个互补层组成，哈佛 Dataverse 和 Basecamp，允许从任何有互联网的位置或设备进行安全访问此外，它还认识到核心 A CL 定期监控数据累积的持续责任。 PPG 的整体进展是通过与科学界快速有效地共享数据来实现的通过基于网络的技术和持续致力于以开放获取方式发布适当的调查结果期刊，或利用参与机构的公共关系资源与非专业人士共享数据民众。 2) 监控并最大化项目进度、项目/核心之间的协同作用以及核心利用率。创建项目和核心之间要实现的共同商定的里程碑，它们的集中化监控和维护涉及项目/核心和核心 A 的持续反馈循环，以最大限度地提高投射动力，拦截并解决任何可能抑制或延迟进展的问题，监控各个方面与可重复性相关，并确保以有重点的方式实现适当的可交付成果，以确保转化相关性和最终的临床应用该目标是按定期（每月）安排的。涉及所有项目和核心领导的互动，在此期间可以评估和最大化进度。 3) 为 PPG 提供一般行政支持，包括 a) 每月会议的安排；与外部顾问委员会 (EAB) 建立和安排定期会议以审查进展情况协助规划； c) 调解和解决冲突； d) 准备非竞争性续约；申请和进度报告； e) 预算管理； f) 机构协调和便利 g) 向 PubMed Central 提交稿件并管理新创建的知识产权；包括准备并向 OTD 提交新发明披露）。