Systematic Light Exposure Intervention for Fatigue and Cognitive Efficiency in Pediatric Brain Tumor Survivors

系统性光照干预对小儿脑肿瘤幸存者的疲劳和认知效率

基本信息

批准号：
10493438
负责人：
HEATHER M CONKLIN
金额：
$ 20.81万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-23 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10493438
关键词：
Academic achievement Address Adherence Adolescent Adolescent and Young Adult Adult Adverse effects Affect Age Area Attention Biological Markers Brain Brain Neoplasms Cancer Survivor Child Childhood Childhood Brain Neoplasm Circadian Rhythms Cognition Cognitive Data Detection Diagnosis Distress Double-Blind Method Drowsiness Effectiveness Emotional Enrollment Environment Fatigue Goals Hormones Household Impairment Income Inflammatory Intervention Intervention Trial Late Effects Light Literature Malignant Neoplasms Methods Moods Neurobehavioral Manifestations Neurocognitive Neurocognitive Deficit Outcome Parents Participant Patient Recruitments Patients Performance Periodicity Persons Phase Pilot Projects Placebo Control Population Populations at Risk Proxy Publishing Quality of life Randomized Randomized Controlled Trials Recording of previous events Reporting Research Research Infrastructure Risk Self Management Short-Term Memory Sleep Sleep Wake Cycle Solid Solid Neoplasm Survival Rate Survivors Symptoms Time Treatment Efficacy Treatment Side Effects alertness base cancer therapy circadian cognitive benefits cognitive function cohort computerized cost effective intervention effectiveness evaluation efficacy evaluation experience follow-up functional outcomes health related quality of life hypothalamic pituitary axis hypothalamic-pituitary-adrenal axis improved information processing interest memory process multidisciplinary patient population poor sleep post intervention prevent processing speed programs side effect social success theories treatment effect

项目摘要

PROJECT SUMMARY/ABSTRACT Due to advances in detection and treatment, there is a rapidly increasing population of survivors of pediatric brain tumor. With increased survival rates, there is greater emphasis on managing the late effects of pediatric brain tumor. Cognitive symptoms are prevalent among survivors and are associated with poor academic achievement, vocational success, and overall quality of life. However, few interventions have been trialed to reduce cognitive symptoms. To this end, fatigue is a common late effect of brain tumor and its treatment, and it significantly reduces cognitive efficiency, including attention and speed of processing information. Among survivors, interventions that are low cost, non-pharmacological, and appropriate for self-management are highly desired but rare. Systematic bright light exposure has been shown to be effective for improving sleep and reducing fatigue among adolescent and adult patient populations, including adolescent and young adult solid tumor, and adult cancer survivors. The purpose of the proposed study is to evaluate the feasibility and preliminary effectiveness of systematic bright light exposure for reducing fatigue and improving cognitive efficiency among pediatric brain tumor survivors. Forty survivors (ages 10-18 years) will be asked to wear systematic light exposure glasses for 30 minutes upon awakening for a six week period with follow-up at 2- weeks post-intervention. Systematic bright light exposure (intervention) will be compared to dim light exposure (placebo-control). As part of this study, we focus on intervention fidelity, using an integrated app recording timing and duration of light exposure; and adverse side effects associated with light exposure. We assess preliminary outcomes associated with patient and parent-proxy reports of fatigue and cognitive efficiency using in-person and remote administration of a computerized battery. The ultimate goal of this line of research is to trial interventions that mitigate cognitive late effects to improve quality of life in pediatric brain tumor survivors. Findings from this pilot study will be used to refine the intervention and inform a larger randomized controlled trial.

项目概要/摘要由于检测和治疗方面的进步，儿科幸存者人数迅速增加脑肿瘤。随着生存率的提高，人们更加重视管理儿科的后期影响脑肿瘤。认知症状在幸存者中普遍存在，并且与学业成绩不佳有关成就、职业成功和整体生活质量。然而，几乎没有尝试过干预措施减少认知症状。为此，疲劳是脑肿瘤及其治疗的常见迟发效应，显着降低认知效率，包括注意力和处理信息的速度。之中对于幸存者来说，低成本、非药物且适合自我管理的干预措施是非常需要但很少见。系统性强光照射已被证明可有效改善睡眠减少青少年和成年患者群体（包括青少年和年轻人）的疲劳实体瘤和成年癌症幸存者。拟议研究的目的是评估可行性和系统性强光照射对减轻疲劳和改善认知的初步效果儿童脑肿瘤幸存者的效率。四十名幸存者（年龄 10 至 18 岁）将被要求穿着醒来后系统性地使用眼镜曝光 30 分钟，持续六周，并在 2-2 小时进行随访干预后几周。系统性强光照射（干预）将与弱光照射进行比较（安慰剂对照）。作为本研究的一部分，我们使用集成应用程序记录来关注干预保真度光照时间和持续时间；以及与光照相关的不良副作用。我们评估与患者和家长代理疲劳和认知效率报告相关的初步结果计算机化电池的现场和远程管理。这一系列研究的最终目标是减轻认知迟发效应以改善儿科脑肿瘤幸存者的生活质量的试验干预措施。这项试点研究的结果将用于完善干预措施并为更大的随机对照研究提供信息审判。