Administrative Core (AC) Core A

行政核心 (AC) 核心 A

• 批准号: 10491844
• 负责人: CAROL A. BARNES
• 金额: $ 664.8万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491844
• 关键词: Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Bioinformatics; Brain; Businesses; Cognitive; Cognitive aging; Collection; Communication; Communities; Complex; Conflict of Interest; Country; Data; Development; Effectiveness; Ensure; Epidemiology; Evaluation; Fostering; Funding; Goals; Grant; Health; Health Professional; Human Resources; Human Subject Research; Intellectual Property; Intervention; Lead; Leadership; Longevity; Longitudinal cohort; Measures; Monitor; Output; Performance; Personal Satisfaction; Process; Productivity; Reporting; Research; Research Personnel; Resource Sharing; Resources; Services; Travel; Universities; Update; algorithmic methodologies; analytical method; base; clinical research site; commercialization; design; experience; follow-up; healthspan; industry partner; meetings; member; molecular marker; operation; outreach; prevent; recruit; success; tool

SUMMARY/ABSTRACT: Administrative Core A The Administrative Core (AC) will lead and coordinate operations of all Cores and Projects to assure success in achieving the strategic goals of the Precision Aging Network (PAN). PAN’s goals are to enable the development of individualized interventions to maintain health, well-being, and function to optimize cognitive healthspan and to prevent or reduce the burden of Alzheimer’s disease (AD) and AD-related dementias (ADRD). The AC will be led by Carol Barnes and Meredith Hay who have a combined several decades worth of administrative experience in directing large, complex projects. They will be assisted by the PAN Executive Committee and Steering Committee and advised by the External Advisory Committee in establishing priorities for center activities and resources, promoting optimal interactions, resolving potential conflicts of interest, reviewing and updating the research community, and implementing an ongoing evaluation plan with appropriate metrics and markers of productivity and impact. Key functions of the AC also include ensuring a robust data and biospecimen sharing plan, meeting coordination and follow-up, travel arrangements, financial allocations and reports, compliance with federal and institutional grants management and reporting requirements, collection, collation and confirmation of evaluation metrics. Overall progress will be assessed through the development of a multi-year Evaluation Plan with specific milestones to identify areas for improvement and initiate changes. The plan will be specifically designed to assess the (a) overall performance of PAN, including the effectiveness of the AC, and (b) productivity, effectiveness, utilization and opportunities of the Cores and Projects, and also (c) actively engage the external advisors in evaluation of the PAN leadership. Lastly, the AC will strengthen and expand robust, effective communication, dissemination and outreach activities by fostering mutually productive interactions among members of health professional, scientific and citizen communities. With input from the External Advisory Committee and NIA programmatic leadership, the Project Leads, co- Leads, Associate Investigators, and key personnel, the AC will ensure that PAN provides a broad-based data, biospecimen and resource sharing plan to facilitate the rapid and far-reaching use of the unique resources (biospecimens, raw and processed data, algorithms, and analytical methods) created by PAN. They will also expand interactions with the leadership and key personnel of other NIA-funded Alzheimer’s Disease Centers located at the four PAN clinical sites as well as across the country. Additionally, the AC will manage interactions with existing longitudinal cohorts designed to investigate aging, AD, and/or ADRD.

摘要/摘要：行政核心 A 行政核心 (AC) 将领导和协调所有核心和项目的运作，以确保成功 实现精准老龄化网络 (PAN) 的战略目标是： 制定个体化干预措施以维持健康、福祉和功能以优化认知 健康寿命并预防或减轻阿尔茨海默病 (AD) 和 AD 相关痴呆症的负担 （ADRD）。 AC 将由卡罗尔·巴恩斯 (Carol Barnes) 和梅雷迪思·海伊 (Meredith Hay) 领导，他们总共拥有数十年的经验 他们将得到 PAN 执行官的协助。 委员会和指导委员会并由外部咨询委员会就确定优先事项提供建议 对于中心活动和资源，促进最佳互动，解决潜在的利益冲突， 审查和更新研究界，并实施持续的评估计划 生产力和影响力的适当指标和标记。 AC 的主要职能还包括确保稳健的数据和生物样本共享计划、会议 协调和后续行动、旅行安排、财务分配和报告、遵守联邦和 机构赠款管理和报告要求、评估的收集、整理和确认 总体进展将通过制定多年评估计划来评估 该计划将具体确定需要改进的领域并启动变革。 旨在评估 (a) PAN 的整体绩效，包括 AC 的有效性，以及 (b) 核心和项目的生产力、有效性、利用和机会，以及 (c) 积极参与 最后，审计委员会将加强和扩大强有力的、 通过促进互惠互利的互动开展有效的沟通、传播和外展活动 卫生专业人员、科学界和公民社区的成员。 根据外部咨询委员会和 NIA 计划领导的投入，项目负责人、共同 AC 将确保 PAN 提供广泛的数据、 生物样本和资源共享计划，促进独特资源的快速和深远利用 （生物样本、原始和处理数据、算法和分析方法）他们还将由 PAN 创建。 扩大与 NIA 资助的其他阿尔茨海默病中心的领导层和关键人员的互动 此外，AC 将负责管理位于四个 PAN 临床中心以及全国各地的项目。 与旨在研究衰老、AD 和/或 ADRD 的现有纵向队列的相互作用。