Pharmacological Sciences Training Program (PSTP)

药理科学培训计划（PSTP）

• 批准号: 10491483
• 负责人: Patrick Alexander Forcelli
• 金额: $ 15.61万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491483
• 关键词: Pharmacology; Science; Training Programs

Project Summary The Pharmacological Sciences Training Program (PSTP) at Georgetown University Medical Center is new, interdisciplinary and integrated program that will bring together an inclusive and diverse community of doctoral candidates across Ph.D. disciplines who are dedicated to thesis research in pharmacological science. Faculty mentors in the PSTP share major research strengths in identifying drug targets within cellular signaling pathways to treat human disease. The 28 mentor and 11 preceptor faculty in the program all have a strong history of mentorship and research programs in drug development for disease treatment with >$30 million in annual research funding. Trainees in the program are drawn from Ph.D. programs in Pharmacology & Physiology, Biochemistry, Tumor Biology, and Neuroscience. Trainees will prepare for future careers in academia, pharma or biotechnology industry, or drug regulatory agencies. This application seeks annual funding for six predoctoral students, providing a catalyst to bring together the four feeder programs, and would be the only NIGMS T32 at GU. Trainees will enter the program in their second year of graduate school, will be supported for their second and third years, and will have ongoing participation throughout the remainder of their degree. Trainees take a comprehensive set of core courses in pharmacological sciences, physiological/biochemical principles integral to pharmacology, and specialized electives in pharmacology relevant to their research. Recognizing the interdisciplinary nature of pharmacological sciences, students will have additional exposure to bioinformatics, molecular and cellular biology, and biostatistics that integrate pharmacology. Our courses take a wide view ranging from cellular networks to organ function to behavior and systems medicine. Training will enhance their understanding of drug mechanisms specific to their field of study and research, and enable them to characterize novel drug targets and signaling pathways in disease. Both trainees and mentors will participate in structured mentor training. During the period of support, all trainees will have two dedicated blocks for internships: one part- time, semester-long placement will occur at Georgetown (e.g., regulatory affairs, technology commercialization); the second block will be summer internship at a local partnering institution (biotech, government, foundations). Thus, our trainees will gain broad exposure to transferable skills across career paths while developing their research abilities. We have set program goals to include (1) achieving a 95% degree attainment within 5.5 years of matriculation, (2) achieving 30% representation of underrepresented groups in our trainee pool, (3) achieving 100% participation of mentors and trainees in formal mentor training, (4) achieving four high-impact publications per trainee, (5) achieve 75% job placement in pharmacology-related careers within two years of degree, (6) continuing to expand our internship opportunities, and (7) increasing the adoption of best practices in graduate admissions. We are committed to training the next generation of pharmacological scientists, building on the strengths of Georgetown’s long track record of success in pharmacology.

项目概要 乔治城大学医学中心的药理学科学培训计划 (PSTP) 是新推出的， 跨学科和综合项目，将汇集一个包容和多元化的博士生社区 致力于药理学论文研究的跨学科博士候选人。 PSTP 的导师在识别细胞信号通路中的药物靶标方面拥有共同的主要研究优势 该项目的 28 名导师和 11 名导师均拥有悠久的治疗人类疾病的历史。 疾病治疗药物开发的指导和研究项目每年投入超过 3000 万美元 该计划的受训者来自药理学和生理学博士课程， 生物化学、肿瘤生物学和神经科学的学员将为未来在学术界、制药业的职业生涯做好准备。 或生物技术行业，或药物监管机构该申请寻求年度资助六名博士前。 学生，为将四个支线计划结合在一起提供了催化剂，并且将是唯一的 NIGMS T32 GU. 学员将在研究生院第二年进入该计划，并在第二年获得支持 第三年，学员将持续参与剩余的学位课程。 药理科学、生理/生化原理的综合核心课程 药理学，以及与其研究相关的药理学专业选择。 药理学科学的跨学科性质，学生将额外接触生物信息学， 我们的课程视野广阔，涵盖分子和细胞生物学以及整合药理学的生物统计学。 从细胞网络到器官功能再到行为和系统医学，培训将增强他们的能力。 了解其研究领域特有的药物机制，并使他们能够表征 学员和导师都将参加结构化的疾病治疗新药物靶点和信号通路。 培训期间，所有学员都会有两个专门的实习导师区块：一是—— 届时，整个学期的实习将在乔治城大学进行（例如监管事务、技术商业化）； 第二部分将是在当地合作机构（生物技术、政府、基金会）的暑期实习。 因此，我们的学员将广泛接触跨职业道路的可转移技能，同时发展他们的能力 我们设定的项目目标包括 (1) 在 5.5 年内实现 95% 的学位获得率。 入学率，(2) 在我们的学员库中实现代表性不足群体的 30%，(3) 实现 导师和学员100%参与正式导师培训，（4）实现四篇高影响力出版物 每个学员，(5) 在获得学位的两年内实现 75% 的药理学相关职业就业，(6) 继续扩大我们的实习机会，以及 (7) 增加毕业生中最佳实践的采用 我们致力于培养下一代药理学科学家，以培养下一代药理学科学家。 乔治城大学在药理学方面的长期成功记录的优势。