mHealth app for caregiver instruction in manual therapy for chemotherapy-induced peripheral neuropathy

mHealth 应用程序用于指导护理人员进行化疗引起的周围神经病变的手法治疗

• 批准号: 10482557
• 负责人: WILLIAM B COLLINGE
• 金额: $ 39.91万
• 依托单位: COLLINGE AND ASSOCIATES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-18 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10482557
• 关键词: Affect; Analgesics; Android; Anticonvulsants; Antidepressive Agents; Automobile Driving; Cancer Survivor; Cancer Survivorship; Caregiver Burden; Caregivers; Caring; Chemotherapy-induced peripheral neuropathy; Chronic; Clip; Clothing; Collection; Communication; Critiques; Data; Development; Devices; Distress; Economic Burden; Educational process of instructing; Elements; Emotional; Equilibrium; FDA approved; Family Caregiver; Family member; Feedback; Focus Groups; Frequencies; Gel; Hand; Health Benefit; Home; Impairment; Industry Standard; Instruction; Interview; Knowledge; Learning; Malignant Neoplasms; Manipulative Therapies; Manuals; Medical Care Costs; Mobile Health Application; Motivation; Multimedia; Needles; Nervous System Trauma; Nervous system structure; Numbness; Oncology; Outcome; Pain; Patient-Focused Outcomes; Patients; Personal Communication; Personal Satisfaction; Phase; Play; Population; Process; Productivity; Protocols documentation; Provider; Public Health; Quality of life; Recommendation; Research; Research Personnel; Role; Safety; Self Efficacy; Shapes; Structure; Supportive care; Symptoms; System; Techniques; Touch sensation; Vitamins; Walking; base; burden of illness; cancer care; caregiver education; caregiving; chemotherapy; daily functioning; design; education resources; evidence base; experience; family burden; foot; human centered design; improved; innovation; loved ones; mHealth; mobile application; persistent symptom; prototype; reduce symptoms; response; skills; symptom management; tool; usability

Chemotherapy can damage nervous system structures leading to chemotherapy-induced peripheral neuropathy (CIPN) which impairs quality of life and daily functioning for millions of cancer survivors. Some 30% of recipients live with CIPN chronically beyond completion of chemotherapy. Conventional care is symptomatic including antidepressants, anticonvulsants, analgesics, vitamin supplements and topical gels to manage symptoms. While there are no FDA-approved treatments, evidence indicates that specific manual therapy techniques can reduce symptoms of CIPN. There is also evidence that caregivers can learn safe and effective manual therapy techniques for use in caregiving through multimedia instruction. However, there currently is no caregiver education product teaching specific techniques and safety precautions pertaining to CIPN. This project will develop a mobile health (mHealth) app to empower caregivers with knowledge, skills, self-efficacy and motivation to support loved ones with CIPN by use of simple manual techniques based on specific understanding and safety precautions for CIPN. The project will use a human-centered design approach in formative research to develop a “minimum viable product (MVP)” for the eventual caregiver mHealth app. A user-centered, iterative process with caregiver focus groups will guide development of the MVP which will then be assessed for feasibility through a Think-Aloud protocol. Specific Aims are as follows: Aim 1. Develop initial user-centered app design. We will develop preliminary requirements for core educational content to be featured in the app, then refine this with patient focus group feedback. The resulting initial app design will incorporate principles of ease of navigation, usability, utility, and engagement. Aim 2. Refine app design through an iterative process of qualitative feedback. The initial app design will be processed and revised through three rounds of caregiver focus groups for qualitative feedback and refinement. Qualitative analysis of responses after each round will be conducted, and applied to produce revised versions through round 3, resulting in the MVP prototype. Aim 3. Evaluate usability of a minimum viable product (MVP). Caregivers will experience the MVP prototype through an interactive Think-Aloud session with the design team that is recorded for qualitative analysis. This will be followed by debriefing with structured interview questions about design, relevance and intent to use. Quantitative data will assess system usability, and perceived relevance and impact on caregiving. Feasibility criteria will be usability scores and user ratings of perceived value and “intent to use” in caregiving. If Phase I is successful the app will be completed in Phase II followed by a large RCT to assess outcomes of use for both CIPN sufferers and caregivers. Eventual public health benefits include improved quality of life and functional well-being for the population of CIPN sufferers, reduced caregiver burden, and reduced economic burden from medical costs and lost productivity associated with CIPN.

化疗会损害神经系统结构，导致化疗引起的外周神经损伤 神经病变 (CIPN) 损害了数百万癌症幸存者的生活质量和日常功能。 接受 CIPN 的患者在完成化疗后仍长期生活，而传统治疗只是对症治疗。 包括抗抑郁药、抗惊厥药、镇痛药、维生素补充剂和外用凝胶来管理 虽然没有 FDA 批准的治疗方法，但有证据表明特定的手法治疗。 技术可以减轻 CIPN 的症状 还有证据表明护理人员可以安全有效地学习。 然而，目前还没有通过多媒体指导用于护理的手法治疗技术。 护理人员教育产品，教授与 CIPN 相关的具体技术和安全预防措施。 该项目将开发一款移动健康 (mHealth) 应用程序，为护理人员提供知识、技能、 通过使用基于 CIPN 的简单手动技术来支持亲人的自我效能感和动机 对CIPN的具体理解和安全注意事项 该项目将采用以人为本的设计。 形成性研究的方法，为最终的护理人员开发“最小可行产品（MVP）” 移动医疗应用程序将由护理人员焦点小组以用户为中心的迭代过程来指导开发。 然后将通过 Think-Aloud 协议评估 MVP 的可行性，具体目标如下： 目标 1. 开发初始的以用户为中心的应用程序设计 我们将为核心制定初步要求。 应用程序中包含教育内容，然后根据患者焦点小组的反馈进行完善。 最初的应用程序设计将纳入易于导航、可用性、实用性和参与度的原则。 目标 2. 通过定性反馈的迭代过程完善应用程序设计 初始应用程序。 设计将通过三轮护理人员焦点小组进行处理和修订，以获得定性反馈 每轮后将对答复进行定性分析，并应用于生产。 经过第三轮的修改版本，产生了 MVP 原型。 目标 3. 评估最低可行产品 (MVP) 的可用性 护理人员将体验 MVP。 通过与设计团队进行交互式思考会议来制作原型，并进行定性记录 随后将进行有关设计、相关性和结构性访谈问题的汇报。 使用意图。定量数据将评估系统的可用性以及对护理的感知相关性和影响。 可行性标准将是可用性分数和用户对护理中感知价值和“使用意图”的评级。 如果第一阶段成功，该应用程序将在第二阶段完成，然后进行大型随机对照试验来评估 CIPN 患者和护理人员的使用结果包括改善公共健康。 CIPN 患者群体的生活质量和功能健康、护理人员的负担减轻以及 减轻与 CIPN 相关的医疗费用和生产力损失带来的经济负担。