Commercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology

用于大规模、持久电生理学的集成电极电子系统的商业化

基本信息

批准号：
10481712
负责人：
Loren M Frank
金额：
$ 90.84万
依托单位：
SPIKEGADGETS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10481712
关键词：
Animals BRAIN initiative Behavior Behavioral Brain Brain Injuries Brain region Chronic Cicatrix Code Complex Computers Consumption Contracts Coupling Data Data Collection Devices Electrodes Electronics Electrophysiology (science)Goals Head Individual Laboratories Lead Macaca Measurement Measures Mechanics Miniaturization Movement Neurons Neurosciences Research Operative Surgical Procedures Pattern Phase Procedures Process Protocols documentation Rattus Readiness Research Personnel Resistance Resolution Rodent Route Sampling Shipping Silicon Site Small Business Innovation Research Grant Sterilization Stream Structure System Techniques Technology Thick Thinness Tissues Tungsten Weight Work analog base behavior measurement commercialization density design digital experimental study flexibility implantation instrument lithography millimeter miniaturized device neurotechnology next generation nonhuman primate parity prototype relating to nervous system scale up tool user-friendly

项目摘要

PROJECT SUMMARY Examining how behavior arises from the complex interconnected activity of the brain is a cornerstone of neuroscience research. A recent technological advance in neurotechnology is enabling studies where the parallel activity of thousands of neurons can be studied in rodent brains. The Neuropixels probe, allowing 384 channels of electrophysiological data to be observed from the brain, is now a valuable tool for next-generation experiments. One goal of this project is to provide a commercial alternative to the Neuropixels probe and associated electronics that will enable feature parity in recording capability, but also be usable in scientific applications currently unaddressed by the existing Neuropixels probe. Our proposed solution is partially enabled by the makers of the Neuropixles probes—IMEC has recently made commercially available the electronics of the probes as a standalone 384 channel chip without the silicon electrodes attached. By connecting this proven technology to a new type of electrode array—flexible polyimide-based probes—we outline a strategy to offer technology with similar channel density that is 1) is resistant to breakage upon insertion, 2) enables closely-spaced implantation sites, and 3) has a significant reduction in glial scarring compared to silicon probes, enabling extremely stable recordings for months. Furthermore, by coupling this probe to powerful datalogging electronics, we will offer a way to scale channel counts to above 3000 without the need for cables between the animal and a computer.

项目概要检查行为是如何从大脑复杂的相互关联的活动中产生的是一个神经科学研究的基石是神经技术的最新技术进步。使研究能够在啮齿动物中研究数千个神经元的并行活动 Neuropixels 探针，可观察 384 个通道的电生理数据来自大脑的，现在是下一代实验的一个有价值的工具。提供 Neuropixels 探针和相关电子产品的商业替代品实现记录功能的功能对等，而且目前也可用于科学应用现有的 Neuropixels 探针未解决这个问题，我们提出的解决方案部分是由 Neuropixles 探针的制造商——IMEC 最近将探头的电子器件作为独立的 384 通道芯片，没有硅电极通过将这种成熟的技术连接到一种新型的柔性电极阵列。基于聚酰亚胺的探针——我们概述了提供具有相似通道密度的技术的策略即 1) 插入时不易破裂，2) 可实现紧密间隔的植入位点， 3) 与硅探针相比，神经胶质疤痕显着减少，从而使此外，通过将该探头与强大的数据记录相结合，可以保持数月的稳定记录。电子产品方面，我们将提供一种无需电缆即可将通道数扩展到 3000 以上的方法动物和计算机之间。