Methodology Core

方法论核心

基本信息

批准号：
10477005
负责人：
Hilal Maradit Kremers
金额：
$ 35.92万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-16 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10477005
关键词：
Address Adopted American American College of Surgeons Area Caring Clinic Clinical Data Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Consult Consultations Custom Data Data Set Data Sources Databases Dissemination and Implementation E-learning Education Electronic Health Record Ensure Epidemiology Evidence based practice Future Goals Health Health Care Costs Health Services Research Healthcare Systems Hospitals Human Resources Improve Access Informatics Infrastructure Intervention Studies Joint Prosthesis Joints Learning Module Link Medicare claim Mentors Methodology Methods Midwestern United States National Institute of Arthritis and Musculoskeletal and Skin Diseases Observational Study Online Systems Operative Surgical Procedures Outcome Outcomes Research Patient Outcomes Assessments Recording of previous events Registries Replacement Arthroplasty Research Research Design Research Infrastructure Research Methodology Research Personnel Research Project Grants Resources Risk Risk Factors Science Services Severity of illness Standardization Statistical Data Interpretation Training Training Support Translational Research United States National Institutes of Health clinical center collaboratory data management data registry data resource data warehouse education research effectiveness outcome flexibility health care service utilization high standard implementation research informatics tool innovation joint infection next generation novel programs protocol development radiological imaging statistics study population success surgical risk systems research

项目摘要

ABSTRACT - METHODOLOGY CORE Clinical research in total joint arthroplasty (TJA) demands the highest standards of study design while leveraging existing data sources and adopting standardized definitions and novel clinical research methodologies. TJA researchers need to be well-trained and supported if they are to respond effectively to current and emerging research gaps in TJA. The Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) Methodology Core will build upon Mayo’s existing methodology resources to advance the science of TJA clinical research at the national level by providing high-quality consulting, education and mentoring services, and state-of-the-art and novel methodology resources, facilitating optimal use of existing stand-alone or linked databases and clinical research networks, training of the next generation of TJA clinical investigators and building scientific collaborations. The Specific Aims of the CORE-TJA Methodology Core are: (1) To enhance TJA clinical research at the national level by providing consultation, education and mentoring services for TJA investigators, (2) To leverage existing databases and clinical research networks to identify the most informative study populations and study designs for TJA clinical research, and (3) To develop and disseminate novel methodologies applicable to observational and interventional study designs in TJA clinical research. Specifically, the Methodology Core will focus on 6 specific methodological areas in TJA research: methods to account for bias and confounding in TJA research, application of TJA-specific informatics tools for automated data extraction from the electronic health records, patient-reported outcomes research, clinical trials embedded in registries and/or healthcare systems, mixed- methods research and implementation research. The CORE-TJA Methodology Core will create a flexible, sustainable research infrastructure, trained workforce and synergistic collaborations at the national level.

摘要 - 方法论核心全关节置换术 (TJA) 的临床研究需要最高标准的研究设计，同时利用现有数据源并采用标准化定义和新颖的临床研究 TJA 研究人员如果要有效应对，就需要接受良好的培训和支持。 TJA 当前和新兴的研究差距。梅奥全关节临床研究核心中心。关节成形术 (CORE-TJA) 方法学核心将建立在梅奥现有的方法资源基础上通过提供高质量的咨询，在国家层面推进 TJA 临床研究的科学性，教育和指导服务，以及最先进和新颖的方法资源，促进最佳使用现有的独立或链接数据库和临床研究网络，培训下一代 TJA 临床研究人员和建立科学合作的具体目标。方法学核心是： (1) 通过提供咨询来加强国家层面的 TJA 临床研究，为 TJA 研究人员提供教育和指导服务，(2) 利用现有数据库和临床研究网络，以确定 TJA 临床信息最丰富的研究人群和研究设计研究，以及（3）开发和传播适用于观察和 TJA 临床研究的介入研究设计具体而言，方法学核心将重点关注 6 个方面。 TJA 研究中的具体方法论领域：解释 TJA 研究中的偏差和混杂因素的方法，应用 TJA 特定的信息学工具从电子健康记录中自动提取数据，患者报告的结果研究、嵌入注册和/或医疗保健系统的临床试验、混合- 方法研究实施和研究 CORE-TJA 方法核心将创建一个灵活的、可持续的研究基础设施、训练有素的劳动力以及国家层面的协同合作。