JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) - Development Core

JHU 艾滋病毒神经治疗促进中心 (JHU CAHN) - 开发核心

• 批准号: 10475438
• 负责人: Ahmet Hoke
• 金额: $ 24.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-16 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475438
• 关键词: Academia; Applications Grants; Area; Award; Behavioral Assay; Biological Assay; Cells; Clinical; Collaborations; Communication; Communities; Complication; Data; Development; Direct Costs; Education; Event; Extramural Activities; Feedback; Fostering; Funding; Goals; Grant; HIV; Health; Human; Institution; International; Investments; Joints; Lead; Leadership; Link; Mentors; Mentorship; Minority Women; Monitor; National Institute of Mental Health; Neurovirology; Opportunistic Infections; Persons; Pilot Projects; Process; Publishing; Research; Research Domain Criteria; Research Personnel; Resources; Retroviridae Infections; Rewards; Rodent Model; Scientific Advances and Accomplishments; Scientist; Seeds; Series; Societies; Structure; Support Groups; System; Testing; Therapeutic; Training; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Viral; Woman; Work; Workforce Development; Writing; career; career development; community engagement; community science; dashboard; deaf; disability; drug candidate; drug development; falls; follow-up; hard of hearing; high reward; high risk; improved; innovation; low socioeconomic status; member; men; minority trainee; neuroAIDS; novel; novel therapeutics; programs; research and development; science education; screening; symposium

PROJECT SUMMARY – DEVELOPMENTAL CORE The JHU NIMH Center Developmental Core was established to promote innovative, high-risk, high-impact NeuroHIV research through the use of Pilot Project Grants. Through the lifecycle of the Developmental Core, 46 pilot projects have funded this type of research. Awardees subsequently published 137 articles directly linked to their pilot funding and obtained over $18 million dollars in subsequent follow-up awards. To align with the Center’s priorities of developing therapeutics for the CNS complications in PWH and to enhance workforce development, we propose the implementation of three new initiatives: 1) establish an online pilot grant dashboard to broaden reviewer participation and career development monitoring; 2) initiate a microgrant funding program to fund cutting-edge technological advances and latest developments in the NeuroHIV field; and 3) initiate a community science education program and a community engagement speaker series to foster the development of scientists who can talk about the significance of their research in a manner that educates, engages, and offers opportunity for participation from members in our HIV community. While most recent data shows that progress is being made in providing support to early stage and new investigators as they advance in their careers to independent investigators, there continues to be a need for directed mitigation strategies for women and underrepresented minority trainees. With these new initiatives as well as close collaboration with the Clinical Core, we expect to over the next five years to strengthen the pilot grant administration process, enhance one- to-one mentoring and opportunities for collaboration between NIMH Centers on novel drug development targeting CNS complication in virally suppressed people with HIV.

项目摘要——开发核心 JHU NIMH 中心发展核心的成立是为了促进创新、高风险、高影响力 通过使用试点项目拨款进行 NeuroHIV 研究，贯穿发展核心的生命周期，46。 试点项目资助了此类研究，获奖者随后发表了 137 篇与此直接相关的文章。 他们的试点资金并在随后的后续奖励中获得了超过 1800 万美元。 中心的优先事项是开发针对感染者中枢神经系统并发症的治疗方法并增强劳动力 开发中，我们建议实施三项新举措：1）建立在线试点拨款仪表板 2）启动小额赠款资助计划 资助 NeuroHIV 领域的尖端技术进步和最新发展；以及 3) 启动 社区科学教育计划和社区参与演讲系列以促进发展 能够以教育、参与和提供的方式谈论其研究的意义的科学家 我们的艾滋病毒社区成员有机会参与，而最新数据表明这方面取得了进展。 正在为早期研究人员和新研究人员提供支持，帮助他们在职业生涯中取得进步 独立调查人员认为，仍然需要针对妇女和儿童制定定向缓解战略 通过这些新举措以及与临床的密切合作。 核心是，我们预计在未来五年内加强试点拨款管理流程，增强一 NIMH 中心之间在新药开发方面的一对一指导和合作机会 针对病毒抑制的艾滋病毒感染者的中枢神经系统并发症。