Discovery Science Collaborative for CKDu

CKDu 发现科学合作

基本信息

批准号：
10471943
负责人：
VIVEK BHALLA
金额：
$ 63.25万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-25 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10471943
关键词：
Acute Acute Renal Failure with Renal Papillary Necrosis Affect Africa Agricultural Workers Agrochemicals Bioinformatics Biological Assay Biological Markers Biopsy Cells Central America Central Asia Characteristics Chronic Chronic Kidney Failure Clinical Collaborations Communities Country Data Data Coordinating Center Databases Developing Countries Diabetes Mellitus Disease Disease Progression Electrolytes Environmental Risk Factor Epidemiology Etiology Evaluation Far East Foundations Functional disorder Funding Genetic Predisposition to Disease Genetic study Genomics Geography Glomerular Filtration Rate Goals Heat Stress Disorders Heterogeneity Hypertension India Individual Inflammatory Infiltrate Infrastructure Injury Injury to Kidney International Investigative Techniques Kidney Kidney Diseases Leadership Manuals Mass Spectrum Analysis Metabolic Pathway Methods Molecular National Institute of Diabetes and Digestive and Kidney Diseases Natural History Nephrology Participant Pathogenesis Pathology Patients Persons Physiology Population Predisposition Proteins Proteomics Recording of previous events Regulation Renal function Reporting Research Resources Risk Factors Role Sampling Science Serum Site South America Sri Lanka Technology Time Toxic Environmental Substances Tubular formation United States National Institutes of Health Work agricultural community base biobank biomarker development case control clinical phenotype community based participatory research comorbidity data integration design diagnostic strategy digital pathology emerging pathogen experience experimental study flexibility kidney biopsy machine learning algorithm metabolomics molecular pathology noninvasive diagnosis novel imaging technology outcome prediction pathogen single cell sequencing tool transcriptomics urinary working group

项目摘要

PROJECT SUMMARY / ABSTRACT The overall goal of the Discovery Science Collaborative for CKDu Renal Science Core is to bring the best investigative methods and scientific technology to the problem of CKDu. We will work closely with Field Epidemiology Sites, the Scientific Data Coordinating Center, NIDDK Leadership, the External Oversight Committee, and HHEAR to design clinical phenotyping studies and perform discovery science experiments. We will then integrate this data to elucidate the etiology and progression factors of CKDu occurring in diverse agricultural communities. The Renal Science Core is a multi-institutional collaborative organized around six Core components: Genomics, Pathology, Transcriptomics, Biomarkers, Physiology, and Bioinformatics. The specific aims of the RSC are to: (1) characterize the clinical phenotypes and natural history of patients with CKDu and unaffected individuals in CKDu-endemic regions, comparing features across CKDu sites and determining the degree of similarities and differences across sites and regions; (2) introduce cutting-edge molecular technologies to compare the risk factors and pathophysiology of CKDu across and within study sites to understand both shared and unique aspects of the etiology of disease; (3) define the relationship between AKI and CKDu in endemic regions; and (4) build a flexible, adaptable infrastructure for both hypothesis- and non-hypothesis-based approaches to understanding etiology that will form the core of ongoing CKDu studies. The leadership team of the RSC has extensive experience working on CKDu, a history of collaboration on international working groups, and leadership roles on other major NIDDK consortia. This group brings together expertise in nephrology, genomics, nephropathology, machine learning algorithms for digital pathology, single- cell transcriptomics, biomarker development, proteomics, metabolomics, renal physiology, bioinformatics, and data integration. We have also enlisted several advisors with expertise in novel pathogen discovery, novel imaging technologies, and environmental sampling. These studies will result in a greater understanding of the underlying pathophysiology of CKDu.

项目概要/摘要 CKDu 肾脏科学核心发现科学合作组织的总体目标是带来最好的 CKDu问题的研究方法和科学技术。我们将与菲尔德密切合作流行病学站点、科学数据协调中心、NIDDK 领导、外部监督委员会和 HHEAR 设计临床表型研究并进行发现科学实验。然后，我们将整合这些数据来阐明不同疾病中发生的 CKDu 的病因和进展因素。农业社区。肾脏科学核心是一个多机构协作组织，围绕六个核心组成部分：基因组学、病理学、转录组学、生物标志物、生理学和生物信息学。这 RSC 的具体目标是：(1) 描述患有以下疾病的患者的临床表型和自然史的特征： CKDu 和 CKDu 流行地区未受影响的个体，比较 CKDu 站点的特征和确定不同地点和地区之间的相似性和差异程度； (2)引进前沿分子技术来比较研究中心之间和内部 CKDu 的危险因素和病理生理学了解疾病病因学的共同和独特方面； (3)定义之间的关系流行地区的 AKI 和 CKDu； (4) 为假设和假设建立灵活、适应性强的基础设施理解病因学的非基于假设的方法将构成正在进行的 CKDu 研究的核心。 RSC 的领导团队在 CKDu 方面拥有丰富的工作经验，在国际工作组以及其他主要 NIDDK 联盟的领导角色。这个团体汇集了肾病学、基因组学、肾病理学、数字病理学机器学习算法、单细胞转录组学、生物标志物开发、蛋白质组学、代谢组学、肾脏生理学、生物信息学和数据整合。我们还聘请了几位在新型病原体发现、新型病原体发现方面具有专业知识的顾问。成像技术和环境采样。这些研究将有助于人们更好地了解 CKDu 的潜在病理生理学。