Administrative and Coordinating Core

行政协调核心

基本信息

批准号：
10470114
负责人：
MARGARET M MADELEINE
金额：
$ 5.04万
依托单位：
FRED HUTCHINSON CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-18 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10470114
关键词：
Acceleration Accountability Adoption Advocate Biological Assay CLC Gene Cancer Burden Caribbean region Cessation of life Child Clinical Clinical Services Clinical Trials Communication Communities Country Data Dominican Republic Fostering Goals Grant Guidelines HIV Heart Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Human papilloma virus infection Income Information Dissemination Infrastructure Institution International Interruption Laboratories Laboratory Procedures Latin American Lead Leadership Lesion Malignant neoplasm of cervix uteri Methods Modeling Monitor Outcome Paper Periodicity Persons Peru Policies Population Preventative vaccination Prevention Primary Prevention Problem Solving Productivity Protocols documentation Publications Publishing Quality Control Records Reporting Research Research Personnel Resources Risk Safety Schedule Science Scientific Advances and Accomplishments Secondary Prevention Services Site Structure Training Translating Triage Update Vaccination Woman Work base cancer prevention cancer risk cervical cancer prevention co-clinical trial data management experience human subject improved meetings member novel strategies participant safety patient safety premalignant prevent recruit screening skills training success tertiary prevention tool

项目摘要

The overarching goal of the Administrative and Coordinating Core (ACC) is to provide effective leadership to optimize the successful accomplishment of the scientific aims of the Cervical Cancer Prevention Partnership (C2P2) Center in Peru and the Dominican Republic. The management team for the ACC includes three investigators: a Peru-based investigator, Dr. Robinson Cabello, MPI, and two Seattle-based investigators, Dr. Duerr (MPI and Co-Chair Trial 1) and Dr. Madeleine (Contact MPI, Co-Investigator Trials 2 and 3). Together they will provide scientific direction, enhance productivity, liaise with the NCI, and monitor safety, quality, recruitment, and progress toward each of the Aims of the Clinical Trials and service Cores. The Aims of the ACC are as follows: Aim 1 of the ACC is to organize the C2P2 Center by distributing responsibility and accountability throughout the C2P2 Center. The ACC will implement the Triple C (Communication, Cooperation and Coordination) model of project management. This organizational approach will be grounded in meeting regional needs and in respect for working with LAC partners who will lead and sustain the cuttingedge changes we develop together through integrated and interdisciplinary team science. Aim 2 is to facilitate communication and scheduling at all levels of the partnership. The ACC will foster high-level and bidirectional coordination and cooperation directly with unit leaders (Clinical Trial Co-Chairs and service Core Leaders) across the C2P2 Center (i.e., Core teams, Clinical Trial teams, institutions), and with external advisors (i.e., External Scientific Advisory Group and the cross-cutting Partnership Center Coordinating Committee). Aim 3 of the ACC is to lead all trial monitoring and regulatory coordination activities with the assistance of the Data Coordinating Core. The first priority of the ACC is patient safety at both trial sties. Aim 4 of the ACC will provide training and dissemination of findings. The ACC will administratively support the Clinical Trial Co-Chairs through cross-institutional training as needed to refine laboratory assay quality control, data management skills training, and streamlined organizational infrastructure building that will enhance the success of the matrixed partnership. All trial findings will be disseminated through published papers and presentations in the region and at international meetings of policy and guideline makers who will be able to use our trial findings to accelerate progress toward elimination of cervical cancer through prevention. The ACC will provide leadership to accomplish the overall scientific goal of the C2P2 Center to improve the quality and efficiency of cervical cancer prevention in the region.

行政和协调核心 (ACC) 的总体目标是提供有效的领导优化宫颈癌预防科学目标的成功实现秘鲁和多米尼加共和国的合作伙伴关系 (C2P2) 中心。 ACC 的管理团队包括三名调查员：一名秘鲁调查员 Robinson Cabello 博士（MPI）和两名西雅图调查员研究者：Durr 博士（MPI 和试验 1 联合主席）和 Madeleine 博士（联系 MPI，试验 2 联合研究者和3）。他们将共同提供科学指导、提高生产力、与 NCI 联络并监控安全、质量、招募以及实现临床试验和服务核心的每个目标的进展。这 ACC 的目标如下： ACC 的目标 1 是通过分配责任来组织 C2P2 中心以及整个 C2P2 中心的问责制。 ACC 将实施 Triple C（通信、合作与协调）项目管理模式。这种组织方法将扎根于满足区域需求并尊重与拉美和加勒比地区合作伙伴的合作，这些合作伙伴将通过综合和跨学科的团队科学来领导和维持我们共同开发的前沿变革。目标 2 是促进合作伙伴各个层面的沟通和日程安排。 ACC 将直接与单位领导（临床试验联合主席和服务核心）促进高层和双向协调与合作 C2P2 中心（即核心团队、临床试验团队、机构）以及外部的领导者顾问（即外部科学咨询小组和跨领域合作伙伴中心协调委员会）。 ACC 的目标 3 是与监管机构一起领导所有试验监测和监管协调活动数据协调核心的协助。 ACC 的首要任务是两个试验站的患者安全。目标 4 ACC 将提供培训并传播调查结果。 ACC 将在行政上支持临床试验联合主席根据需要通过跨机构培训来完善实验室检测质量控制，数据管理技能培训，以及简化的组织基础设施建设，这将增强矩阵式伙伴关系的成功。所有试验结果将通过发表的论文和在该地区以及政策和指南制定者国际会议上的演讲，他们将能够使用我们的试验结果旨在通过预防加速消除宫颈癌的进展。 ACC 将领导完成C2P2中心的总体科学目标，提高质量和该地区宫颈癌预防的效率。