2022 Optogenetic Approaches to Understanding Neural Circuits and Behavior Gordon Research Conference and Gordon Research Seminar

2022年光遗传学方法理解神经回路和行为戈登研究会议和戈登研究研讨会

基本信息

批准号：
10468364
负责人：
Denise Jade Cai
金额：
$ 2.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-10 至 2023-05-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468364
关键词：
Address Animals Appointment Behavior Behavioral Biochemical Biosensor Brain Cells Chemicals Communities Complex Cytoskeleton Data Development Discipline Disease Engineering Faculty Feedback Fiber Optics Fostering Fright Funding Gene Delivery Generations Genetic Transcription Goals Growth Head Health Hour Imaging Techniques Learning Light Mentors Mentorship Methods Microscope Microscopy Minority Women Modification Molecular Monitor Motivation Neurobiology Neuromodulator Neurons Neurotransmitters Oral Outcome Participant Phosphotransferases Postdoctoral Fellow Process Research Research Personnel Rewards Scientist Social Behavior Stress Students Symptoms Techniques Technology Time Travel Underrepresented Minority Work addiction base brain behavior brain cell career development cost design experience experimental study graduate student in vivo imaging innovation interest meetings neural circuit neuroregulation next generation novel optogenetics posters programs relating to nervous system sensor support network symposium tool tool development unpublished works

项目摘要

Project Summary A goal of many neurobiologists is to understand how the activity of cells and circuits in the brain relate to behavior, learning, and disease symptoms. Prior to optogenetics, it was nearly impossible to establish the sufficiency and necessity of activity in specific cells to the generation or modification of a behavior. Optogenetics refers to a rapidly progressing set of tools that allow researchers to use light to read out and manipulate the activity of genetically defined brain cells. With optogenetics, it is now possible to use light to monitor the activity of cells during behavior and then add or subtract activity from these cells to establish the causal relationship between it and behavior. Although optogenetics is nearly universally used, the proper design and interpretation of optogenetics-based experiments is still challenging. The goal of the 2022 Gordon Research Conference and Gordon Research Seminar on “Optogenetic Approaches to Understanding Neural Circuits and Behavior” meeting is to gather scientists from different disciplines and backgrounds who can collectively present best methods for use of optogenetic tools and recent discoveries made with optogenetics to a diverse group of scientists interested in uncovering the relationship between circuit activity and behavior. We will bring together experts who are providing new innovations in optogenetic approaches, such as new sensors, effectors, and microscopes, with scientists using these approaches to discover the neural underpinnings of behavior. Our hope is through the multiple opportunities provided (i.e., oral presentations, interactive poster sessions, community meals and free-time) both senior and junior scientists (i.e., trainees and junior faculty) will be able to build connections and learn from each other.We request funds to help offset the cost of travel, accommodation and registration for speakers and participants to attend this meeting.

项目概要许多神经生物学家的目标是了解大脑中细胞和回路的活动如何与在光遗传学出现之前，几乎不可能确定行为、学习和疾病症状。特定细胞中的活动对于行为的产生或改变的充分性和必要性。光遗传学是指一组快速发展的工具，使研究人员能够利用光来读出和通过光遗传学，现在可以利用光来操纵基因定义的脑细胞的活动。监测行为过程中细胞的活动，然后添加或减去这些细胞的活动以确定尽管光遗传学几乎被普遍使用，但正确的方法是它与行为之间的因果关系。基于光遗传学的实验的设计和解释仍然具有挑战性。 2022年戈登的目标。关于“理解神经网络的光遗传学方法”的研究会议和戈登研究研讨会 “电路与行为”会议旨在聚集来自不同学科和背景的科学家，他们可以共同介绍使用光遗传学工具的最佳方法以及光遗传学的最新发现向有兴趣揭示电路活动与行为之间关系的不同科学家群体提供。我们将汇集在光遗传学方法方面提供新创新的专家，例如新的传感器、效应器和显微镜，科学家们利用这些方法来发现神经我们的希望是通过提供的多种机会（即口头演讲、互动海报会议、社区聚餐和空闲时间），包括高级和初级科学家（即实习生和初级教师）将能够建立联系并互相学习。我们请求资金来帮助抵消出席本次会议的发言者和与会者的差旅费、住宿费和注册费。