Personalized Medicine in Nevada COBRE

内华达州 COBRE 的个性化医疗

• 批准号: 10458476
• 负责人: MARTIN R SCHILLER
• 金额: $ 213万
• 依托单位: UNIVERSITY OF NEVADA LAS VEGAS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458476
• 关键词: Academic Medical Centers; Accreditation; Address; Advisory Committees; Algorithms; Applied Genetics; Award; Basic Science; Benchmarking; Big Data; Bioinformatics; Biomedical Research; Centers of Research Excellence; Clinical; Clinical Research; Clinical Services; Collaborations; Data; Data Analyses; Development; Diagnosis; Education; Environment; Etiology; Faculty; Fostering; Foundations; Funding; Future; Genetic; Genetic Counseling; Genetic Markers; Genetic Research; Genetic Services; Genome; Genomics; Goals; Grant; Graph; Growth; Healthcare; Human Genetics; Human Genome; Hybrids; Individual; Infrastructure; Institutes; Interdisciplinary Study; Investments; Leadership; Letters; Malignant Neoplasms; Marker Discovery; Measures; Medical; Medical Genetics; Medicine; Mentors; Microglia; Minority-Serving Institution; Modeling; Modernization; Monitor; Nevada; Outcome; Phase; Positioning Attribute; Principal Investigator; Private Sector; Privatization; Prognosis; Recording of previous events; Reference Values; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Role; Schizophrenia; School Nursing; Societies; Students; Training; Translational Research; United States National Institutes of Health; Universities; base; career development; experience; genetic makeup; genetic technology; genome analysis; genome sequencing; genomic data; health care service organization; improved; individualized medicine; medical schools; novel; novel strategies; peer; personalized approach; personalized medicine; precision medicine; programs; psychosocial; role model; standard of care; statistics; success; synergism

ABSTRACT: OVERALL Society is progressing beyond “trial-and-error medicine” into a new data-driven era wherein one's genetic makeup is used to improve accuracy in medical diagnosis, prognosis, and treatment [1,2]. In President Barack Obama's State of the Union Address on January 20, 2015, he mentioned the promise of, and future investment in, personalized medicine. Many experts, including National Institutes of Health (NIH) Director Francis Collins, MD, believe that what is now called personalized, precision, or individualized medicine will transform the future of healthcare. As emerging genetic technologies gradually become the standard of care in some clinical settings, they will continue to improve, driven largely by academic medical centers. Modern genomic and associated bioinformatic analyses have become a staple of modern biomedical research. However, there is no COBRE in personalized medicine, despite its growing influence. The NIH COBRE program aims to strengthen the biomedical research infrastructure and improve competitive research in Institutional Development Award (IDeA)–eligible states. Modern genomic and bioinformatic analyses have become a staple of modern biomedical research. However, no COBRE exists in personalized medicine, despite its growing influence. UNLV is uniquely positioned to deliver on this urgent unmet need. The scientific premise of our COBRE is to advance the use of genomics and genetics in personalized medicine through cutting-edge research discovery and use of genetic markers, building a center of excellence that fosters new investigator independence, and collaborating with the UNLV School of Medicine and other partners in basic and translational research. Consistent with the goal of the NIH COBRE program i to strengthen biomedical research infrastructure and competitive research in IDeA eligible states, we propose three aims: (1) to build a sustained center in personalized medicine; (2) to nurture new investigator growth and independence; and (3) to grow personalized medicine research. To accomplish these goals our proposed COBRE consists of an Administrative core (AC), new Human Genome Data Algorithms to Analytics (HuGe DAtA) core and Genome Analysis and Sequencing Pipeline (GASP) cores, three new investigator research projects (RPs), a mentoring panel of internal and external experts, internal and external advisory committees, and a pilot grant program with 12 awards intended to cultivate a pipeline of new investigators. The leadership and mentoring teams have current research focused on the personalized medicine theme, steady NIH research funding, and a strong mentoring history. This COBRE will establish a foundation to launch medical genetics clinical services and a future educational program in clinical genetics through its collaboration with the UNLV School of Medicine, and through a collaborative educational program in genetic counseling in the School of Nursing. Similar outcomes were leveraged by previous COBRE programs. The major deliverables of the COBRE are RPs advancing personalized medicine, new independent investigators, a new biomedical research infrastructure, and a new program in personalized medicine. The sustainability model is built upon anticipated phase II funding, a pilot grant program, and research core sustainability hybrid models.

摘要：总体 自从基因改变以来，社会正在超越“试错医学”，进入一个新的数据驱动时代 巴拉克总统使用化妆来提高医疗诊断、预后和治疗的准确性[1,2]。 奥巴马在2015年1月20日的国情咨文中提到了承诺和未来的投资 许多专家，包括美国国立卫生研究院 (NIH) 主任弗朗西斯·柯林斯 (Francis Collins)， MD，相信现在所谓的个性化、精准或个性化医疗将改变未来 随着新兴的基因技术逐渐成为一些临床护理的标准。 在现代基因组和学术医疗中心的推动下，它们将继续改进。 相关的生物信息学分析已成为现代生物医学研究的主要内容，但目前还没有。 COBRE 在个性化医疗领域的影响力日益增强，NIH COBRE 计划旨在加强其影响力。 生物医学研究基础设施并提高机构发展奖的竞争力研究 (IDeA)——现代基因组和生物信息学分析已成为现代的主要内容。 然而，尽管 COBRE 的影响力与日俱增，但在个性化医疗领域却并不存在。 UNLV 具有独特的优势，可以满足这一迫切的未满足的需求。我们 COBRE 的科学前提是。 通过前沿研究推进基因组学和遗传学在个性化医疗中的应用 发现和使用遗传标记，建立培养新研究人员的卓越中心 独立性，并与 UNLV 医学院和其他合作伙伴在基础和 与 NIH COBRE 计划的目标一致，即加强生物医学。 在符合 IDeA 条件的州的研究基础设施和竞争性研究中，我们提出三个目标：（1）建立一个 个性化医疗的持续中心；(2) 培养新研究者的成长和独立性； 为了实现这些目标，我们提出的 COBRE 包括： 管理核心 (AC)、新的人类基因组数据分析算法 (HuGe DAtA) 核心和基因组 分析和测序流程 (GASP) 核心、三个新的研究者研究项目 (RP)、一个指导 内部和外部专家小组、内部和外部咨询委员会以及试点赠款计划 领导和指导团队设立了 12 个奖项，旨在培养一批新的研究人员。 目前的研究重点是个性化医疗主题、稳定的 NIH 研究经费以及强大的 辅导历史。 该COBRE将建立一个基金会来开展医学遗传学临床服务和未来 通过与 UNLV 医学院合作开展临床遗传学教育计划，以及 通过护理学院遗传咨询合作教育项目取得了类似的成果。 之前的 COBRE 计划充分利用了 COBRE 的主要成果是推进 RP。 个性化医疗、新的独立研究者、新的生物医学研究基础设施以及新的 个性化医疗项目的可持续性模型是建立在预期的第二阶段资金基础上的，这是一个试点。 资助计划，以及研究核心可持续发展混合模型。

项目成果

Paired-end mappability of transposable elements in the human genome.

人类基因组中转座元件的双端可定位性。

• 发表时间: 2019
• 影响因子: 4.9
• 作者: Sexton, Corinne E;Han, Mira V
• 通讯作者: Han, Mira V

Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis.

佛手柑是一种在葡萄柚汁中发现的 CYP3A 抑制剂，通过下调雄激素受体信号传导并促进 G0/G1 细胞周期阻滞和细胞凋亡来抑制前列腺癌细胞的生长。

• 发表时间: 2021
• 影响因子: 3.7
• 作者: Vetrichelvan, Opalina;Gorjala, Priyatham;Goodman Jr, Oscar;Mitra, Ranjana
• 通讯作者: Mitra, Ranjana

XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks.

XRCC4 和 MRE11 的作用以及对修复 TALEN 诱导的双链 DNA 断裂的转录反应。

• 发表时间: 2022-01-06
• 影响因子: 5.6
• 作者: Benjamin, Ronald;Banerjee, Atoshi;Wu, Xiaogang;Geurink, Corey;Buczek, Lindsay;Eames, Danielle;Trimidal, Sara G;Pluth, Janice M;Schiller, Martin R
• 通讯作者: Schiller, Martin R

Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial.

一天中的时间和与时间类型相关的同步效应运动引起的偏头痛负荷减少：一项试点交叉随机试验。

• 发表时间: 2023-01-23
• 作者: Malek, Elias M;Navalta, James W;McGinnis, Graham R
• 通讯作者: McGinnis, Graham R

Accurate Prediction of Transcriptional Activity of Single Missense Variants in HIV Tat with Deep Learning.

利用深度学习准确预测 HIV Tat 中单个错义变异体的转录活性。

• 发表时间: 2023-03-24
• 影响因子: 5.6
• 作者: Derbel, Houssemeddine;Giacoletto, Christopher J;Benjamin, Ronald;Chen, Gordon;Schiller, Martin R;Liu, Qian
• 通讯作者: Liu, Qian