Admin-Core-001

管理核心-001

基本信息

批准号：
10220175
负责人：
MARTIN R SCHILLER
金额：
$ 37.08万
依托单位：
UNIVERSITY OF NEVADA LAS VEGAS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10220175
关键词：
Accreditation Advisory Committees Algorithms Applications Grants Area Award Benchmarking Big Data Bioinformatics Cell Nucleus Centers of Research Excellence Collaborations Consult Consultations Contracts Data Data Analyses Development Diagnostic Doctor of Philosophy Education Ensure Environment Faculty Foundations Funding Gene Expression Regulation Genetic Genetic Markers Genetic Research Genetic Services Genomics Goals Grant Grant Review Graph Human Genetics Human Genome Informatics Infrastructure Institutes Laboratory Research Leadership Measures Medical Genetics Mentors Monitor Nevada Participant Performance Phagocytosis Phase Preparation Price Process Reporting Research Research Infrastructure Research Personnel Research Project Grants Role Running Sampling Schizophrenia Scientist Seeds Services Structure United States National Institutes of Health Work base career development data quality diagnostic biomarker epigenetic marker experience functional genomics genome analysis genome sequencing genomic data health care service organization improved innovation medical schools member novel peer personalized medicine prodromal Alzheimer&apos s disease prognostic programs psychosocial recruit role model skills smoking addiction testing services

项目摘要

ABSTRACT: ADMINISTRATIVE CORE The Personalized Medicine in Nevada COBRE's long-term goal is to establish itself as a nucleus to enhance human genetics research, as well ss the discovery and application of genetic and epigenetic markers. The proposed COBRE builds upon existing strengths, seed funding from the Nevada Governor's office, and collaboration with the newly accredited UNLV School of Medicine. During the COBRE phase I, we will establish a research program in human genetics and informatics. The major goals are to (Aim 1) administer the program, monitor progress, and iteratively improve the COBRE program; (Aim 2) mentor new investigators to become independent; (Aim 3) expand the human genetics infrastructure at UNLV, in Nevada, and in the IDeA Network; and (Aim 4) cultivate a pipeline of new independent investigators for personalized medicine research. The new investigators and pilot grant awardees will be supported by two research cores centered on genomics and bioinformatics, and a mentoring plan based upon best practices and preliminary studies. The new Genome Analysis and Sequencing Pipeline (GASP) and the Human Genome Data Algorithms to Analytics (HuGe DAtA) Cores, leverage UNLV and local infrastructure The Administrative Core (AC) will be run by PI, Martin Schiller and Co-PI, Xiangning Chen. The external and internal advisory committees, along with consultants will help guide them on COBRE program decisions. The AC will have an oversight role over two research cores, three new investigator research projects, a pilot grant program, and a mentoring panel. The main responsibilities for the Administrative Core are: providing leadership, governance of the COBRE, fiscal management, promoting interactions among institute participants and with external organizations, assessing performance, reporting to NIH, program oversight, and organization of mentoring activities. The AC will work with an independent Program Assessor to monitor progress toward key milestones and benchmarks for the program, and use this information in consultation with the external advisory boards for cycles of improvement each year. Some of the innovative aspects of this proposal are: (1) the COBRE research theme on discovery and application of genetic and epigenetic markers for personalize medicine; (2) having new investigators review grants for Grant Club and the CTR-IN Advance to Funding program; (3) the GASP Core supporting the use and ensure quality of other core services; and (4) a novel assessment approach using graph analytics as a surrogate for measuring culture.

摘要：行政核心内华达州的个性化医疗 COBRE 的长期目标是将自己打造成核心，以增强人类遗传学研究，以及遗传和表观遗传标记的发现和应用。这拟议的 COBRE 建立在现有优势、内华达州州长办公室的种子资金以及与新认可的 UNLV 医学院合作。在 COBRE 第一阶段，我们将建立人类遗传学和信息学研究项目。主要目标是（目标 1）管理该计划，监控进展并迭代改进 COBRE 计划；（目标 2）指导新研究者成为独立的; （目标 3）扩大内华达州内华达大学拉斯维加斯分校和 IDeA 网络的人类遗传学基础设施；（目标 4）为个性化医学研究培养一批新的独立研究者。新的研究人员和试点资助获得者将得到两个以基因组学为中心的研究核心的支持生物信息学，以及基于最佳实践和初步研究的指导计划。新基因组分析和测序管道 (GASP) 以及人类基因组数据分析算法 (HuGe DAtA) 核心，利用 UNLV 和当地基础设施行政核心 (AC) 将由 PI Martin Schiller 和联合 PI Chen Xianning 负责管理。外部和内部咨询委员会以及顾问将帮助指导他们做出 COBRE 计划决策。这 AC 将监督两个研究核心、三个新的研究者研究项目、一项试点拨款计划和指导小组。行政核心的主要职责是：领导力、COBRE 治理、财务管理、促进机构参与者之间的互动并与外部组织合作，评估绩效、向 NIH 报告、项目监督和组织的辅导活动。审计委员会将与独立的计划评估员合作，监督进展情况该计划的关键里程碑和基准，并与外部协商使用此信息每年都有改进周期的咨询委员会。该提案的一些创新点是：（1） COBRE 研究主题是遗传和表观遗传标记的发现和应用，以实现个性化药品; (2) 让新的调查员审查 Grant Club 和 CTR-IN Advance to Funding 的拨款程序; （3）GASP Core配套使用并保证其他核心服务的质量； (4) 一本小说使用图形分析作为衡量文化的替代方法的评估方法。