Administrative Core

行政核心

基本信息

批准号：
10458537
负责人：
Robert P Schleimer
金额：
$ 11.38万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10458537
关键词：
Administrator Asthma Attention Award Biological Assay Biometry Bronchiectasis Budgets Chicago Clinical Collaborations Communication Communities Data Data Set Discipline Doctor of Philosophy Ensure Environment Epidemiologist Epidemiology Funding Future Goals Government Agencies Grant Human Resources Hypersensitivity Immunologist Immunology Individual Institution Interdisciplinary Study Internet Link Lung diseases Maintenance Manuscripts Medical Students Molecular Nasal Polyps Natural History Office of Administrative Management Otolaryngologist Outcome Pathogenesis Patients Persons Phenotype Play Postdoctoral Fellow Preparation Progress Reports Publications Recording of previous events Reporting Research Research Personnel Role Scholarship Services Severities Site Symptoms System Teleconferences Training Translating United States National Institutes of Health Woman Work base chronic rhinosinusitis clinical phenotype comorbidity data handling data sharing disease heterogeneity doctoral student innovation meetings member men programs promoter synergism web site

项目摘要

ABSTRACT The Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2) is an integrated program of epidemiologists, otolaryngologists, allergists and immunologists in which highly collaborative studies are proposed to better understand the molecular and cellular mechanisms of disease heterogeneity and how these mechanisms translate into clinical phenotypes, natural history and long term outcomes. The program focuses particular attention to CRS without nasal polyps (CRSsNP), a highly prevalent and yet obscure phenotype from the standpoint of our current understanding. Another focus of CRISP2 is to critically evaluate the mechanisms and consequences of comorbid conditions in which patients have both CRS and lung disease such as asthma or bronchiectasis. Yet another theme is to make inroads in our understanding of why women are more significantly impacted by CRS than men. In order to achieve these goals, the investigators that comprise the CRISP2 study team have innovated new assays and approaches to cutting edge studies of pathogenesis and epidemiology and, most importantly, have merged these two disciplines to relate mechanisms to symptoms, severity, history and outcomes of CRS. The Administrative Core (Core A) has as its main functions the goals of providing administrative support for the vigorous integrative efforts of the program, facilitating communication and data sharing, catalyzing publications and reporting of the findings of the work, ensuring that the Chronic Rhinosinusitis Integrative Research Program-2 (CRISP2) promotes an effective training function and organizing the advisory board and the regular meetings of the CRISP2 participating centers and investigators. Core A is also responsible for the preparation of progress reports for the program and overseeing regulatory compliance with various institutional and governmental agencies. Core A will play a central role in promoting synergy and advanced collaborative interactions in the program. We have organized these and other functions into the following specific aims: 1.) To provide central administrative services for CRISP2, including oversight of funds distribution, managing the administrative office, facilitating changes that occur in budget, personnel or scientific direction, overseeing preparation of progress reports and assurance of appropriate compliance with directives from the NIH, NU, UC, G/JHU and local, state and federal agencies. The administrative team is Dr. Schleimer (PI), Ms. Valarie Thomas and Ms. Seletta Nichols (administrators) and Dr. Alfred Rademaker (biostatistician). 2.) To facilitate communications in CRISP2 and organize an advisory board. CRISP2 will have four quarterly meetings each year and will maintain an internet-based cloud communications system. 3.) To disseminate discoveries made by CRISP2. Core A will facilitate manuscript preparation and maintenance of a website. 4.) To encourage training. Core A will support an ongoing grant program for young scholars. 5.) To promote interdisciplinary research. Core A will facilitate interactions of the disciplines and individual investigators that are involved in CRISP2.

摘要慢性鼻窦炎综合研究计划 2 (CRISP2) 是一个综合计划流行病学家、耳鼻喉科医生、过敏症专家和免疫学家进行高度合作的研究提出更好地理解疾病异质性的分子和细胞机制以及这些机制如何机制转化为临床表型、自然史和长期结果。该计划重点特别关注不伴鼻息肉的慢性鼻窦炎 (CRSsNP)，这是一种非常普遍但模糊的表型我们目前理解的立场。 CRISP2 的另一个重点是批判性地评估机制以及患者同时患有慢性鼻窦炎和哮喘等肺部疾病的合并症的后果或支气管扩张。另一个主题是加深我们对为什么女性比男性更重要的理解。与男性相比，CRS 的影响更为显着。为了实现这些目标，研究人员组成 CRISP2 研究团队创新了新的检测方法和方法，以进行发病机制和疾病的前沿研究。流行病学，最重要的是，将这两个学科合并起来，将机制与症状联系起来， CRS 的严重程度、病史和结果。行政核心（核心 A）的主要职能是提供行政支持促进该计划的积极综合努力，促进沟通和数据共享，促进出版物和工作结果报告，确保慢性鼻窦炎综合治疗研究计划 2 (CRISP2) 促进有效的培训职能并组织顾问委员会和 CRISP2 参与中心和研究者的定期会议。核心 A 还负责准备该计划的进度报告并监督各机构的监管合规情况和政府机构。核心A将在促进协同和高级协作方面发挥核心作用程序中的交互。我们将这些功能和其他功能组织成以下具体目标：1.) 为 CRISP2 提供中央管理服务，包括监督资金分配、管理行政办公室，促进预算、人事或科学方向发生的变化，监督准备进度报告并确保适当遵守 NIH、NU、UC、 G/JHU 以及地方、州和联邦机构。管理团队为Schleimer博士（PI）、Valarie Thomas女士 Seletta Nichols 女士（管理员）和 Alfred Rademaker 博士（生物统计学家）。 2.) 促进在 CRISP2 中进行沟通并组织一个顾问委员会。 CRISP2 每季度召开四次会议年，并将维护基于互联网的云通信系统。 3.) 传播发现克里斯普2。核心 A 将有助于手稿的准备和网站的维护。 4.) 鼓励培训。核心 A 将支持一项针对年轻学者的持续资助计划。 5.) 促进跨学科研究。核心 A 将促进参与 CRISP2 的学科和个人研究者之间的互动。