A Mentoring Program in Kidney Care for Older Adults

老年人肾脏护理指导计划

基本信息

批准号：
10449851
负责人：
MANJULA KURELLA TAMURA
金额：
$ 10.06万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-15 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10449851
关键词：
Acute Renal Failure with Renal Papillary Necrosis Address Adult Advance Care Planning Affect Age Aging Antihypertensive Agents Area Award Benefits and Risks Blood Pressure Cardiovascular system Caring Cessation of life Chronic Kidney Failure Clinical Trials Data Decision Analysis Dialysis procedure Diastolic blood pressure Discipline Disease Management Disease Progression Education Elderly Electrolyte Disorder Electronic Health Record Event Fostering Frail Elderly Funding Future Glucose Goals Grant Guidelines Health Services Hypertension Impaired cognition Interdisciplinary Study Intervention Investigation Journals Kidney Kidney Diseases Knowledge Mentors Methodology Methods Midcareer Investigator Award in Patient-Oriented Research Mineralocorticoid Receptor Modeling Nursing Homes Organizational Policy Outcome Patient-Focused Outcomes Patients Pharmaceutical Preparations Policy Maker Population Positioning Attribute Program Sustainability Publishing Pulse Pressure Renal function Renin-Angiotensin-Aldosterone System Research Research Personnel Research Project Grants Research Support Resources Risk Scientist Serious Adverse Event Shapes Sodium Structure Study models Systolic Pressure Target Populations Time Training Training Programs United States Department of Veterans Affairs Universities Work antagonist base cardiovascular risk factor career career development clinical center cohort comparative experience hypertension treatment inhibitor mortality multidisciplinary next generation novel novel strategies patient oriented patient population profiles in patients programs randomized trial skills tool training opportunity treatment effect

项目摘要

PROJECT SUMMARY/ABSTRACT This proposal for a Midcareer Investigator Award in Patient-Oriented Research (K24) will support the research program of Dr. Manjula Kurella Tamura, a nephrologist at Stanford University and Director of the Veterans Affairs Palo Alto Geriatric Research and Education Clinical Center. The candidate leads a multi-disciplinary research program which is focused on patient-centered outcomes of dialysis treatment in older adults. Her research program, comprised of a health services component and an interventions component, has been supported by five federally funded awards during the past five years, and has produced an extensive portfolio of work to support hypothesis driven mentee research. During this time, the candidate’s research program has provided training opportunities for 13 junior investigators who have successfully obtained funding, published research in high-impact journals, and transitioned into academic positions. In this K24 application, her overarching goal is to grow and sustain this program by: (1) enhancing her skills as a research mentor by obtaining training in key areas, and (2) using her research as a platform to mentor trainees from a range of disciplines, and (3) extending her research to evaluate treatment trade-offs earlier in the course of kidney disease. Recent clinical trials demonstrate that intensive versus standard blood pressure targets reduce mortality and cardiovascular events, but at the expense of kidney function. The scientific goal of this application is to evaluate the comparative harms and benefits of intensive versus standard hypertension treatment and hypertension deprescribing on kidney end-points in two real world older adult cohorts. The secondary goal is to demonstrate the application of novel analytical approaches that extend causal effects from randomized trials to older and sicker populations. The candidate’s mentoring program will integrate resources from the breadth of training programs at Stanford and VA Palo Alto, with unique opportunities tailored to the career development of scientists in aging research.

项目概要/摘要这项以患者为导向的研究中职业生涯研究者奖 (K24) 的提案将支持斯坦福大学肾病专家 Manjula Kurella Tamura 博士的研究项目帕洛阿尔托大学和退伍军人事务部主任老年研究和教育临床中心候选人领导一个多学科研究项目，重点关注她的研究项目以患者为中心的老年人透析治疗结果。由卫生服务部分和干预部分组成在过去五年中得到了五项联邦资助的奖项的支持，并产生了在此期间，支持假设驱动的受训者研究的广泛工作组合。候选人的研究计划为 13 名初级研究员提供了培训机会，他们已成功获得资助，在高影响力期刊上发表研究成果，并完成转型在这个 K24 申请中，她的首要目标是发展和维持这一点。计划通过：（1）通过获得关键领域的培训来提高她作为研究导师的技能， (2) 利用她的研究作为平台来指导各个学科的学员，以及 (3) 将她的研究扩展到评估肾脏疾病早期的治疗权衡。最近的临床试验表明，强化血压目标与标准血压目标相比会降低死亡率和心血管事件，但以牺牲肾功能为代价。该应用程序旨在评估强化与标准的相对危害和益处两个现实世界中的高血压治疗和高血压对肾脏终点的处方减少第二个目标是展示新颖的分析方法的应用。将随机试验的因果效应扩展到老年人和病情较重的人群的方法。候选人的指导计划将整合各种培训资源斯坦福大学和弗吉尼亚州帕洛阿尔托的课程，提供适合职业生涯的独特机会科学家在衰老研究方面的发展。