University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)

爱荷华大学鹰眼智力与发育障碍研究中心 (Hawk-IDDRC)

基本信息

批准号：
10451564
负责人：
EDWIN TED G. ABEL
金额：
$ 120.89万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-16 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10451564
关键词：
Adult Affect Animals Basic Science Behavior Cellular Phone Child Child Abuse and Neglect Clinical Clinical Research Clinical Sciences Clinical Trials Clinical Trials Design Cognitive Collaborations Communication Communities Conceptions Country Development Developmental Delay Disorders Developmental Disabilities Diagnosis Down Syndrome Early identification Education Educational workshop Electrophysiology (science)Ensure Environment Environmental Risk Factor Epigenetic Process Family Fostering Foundations Funding Future Generations Genes Genetic Genetic Variation Genomics Goals Government Officials Hawks Human Huntington Disease Individual Infrastructure Institutes Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Communication Interdisciplinary Study Intervention Iowa Joints Journals Knowledge Language Development Leadership Life Link Longevity Mentors Midwestern United States Mission Neurodevelopmental Disability Neurosciences Newsletter Parent-Child Relations Patient Recruitments Phenotype Policy Maker Population Population Heterogeneity Positioning Attribute Pregnancy Prevalence Prevention Prevention strategy Publications RNA Recording of previous events Reporting Research Research Personnel Research Project Grants Research Support Resources Risk Factors Risk Marker Rural Rural Population Scientist Series Services Structure Syndrome Talents Time Translational Research Universities autism spectrum disorder biobank clinical care cost effective disability early childhood effective intervention epigenetic regulation exome experience family support gene therapy genome sequencing human old age (65+)improved in utero diagnosis innovation interdisciplinary collaboration meetings neural circuit novel organizational structure pediatric patients pollutant premature prenatal stress prevent programs recruit research facility retention rate rural setting rural underserved social media telehealth systems treatment trial web site whole genome

项目摘要

PROJECT SUMMARY: OVERALL This is a revised application to establish the University of Iowa “Hawkeye” Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC), Our mission is to provide an organizational structure that fully integrates basic and clinical research across the lifespan—from conception to adulthood—that is focused on the prevention, diagnosis, treatment, and amelioration of intellectual developmental disabilities (IDDs), tailored to an underserved rural population. The Hawk-IDDRC includes four components: 1) the Hawk-IDDRC Research Project will examine the interaction of genetic and epigenetic/environmental risks in young children with developmental disabilities, including autism, and integrate services from all four research Cores; 2) Four Research Cores will facilitate interdisciplinary and translational research, including: an Administrative Core (AC) that provides leadership to ensure cost-effective and rigorous IDD research, while inspiring interdisciplinary collaboration and innovation; a Clinical Translational Core (CTC), which will apply basic science discoveries into clinical settings by streamlining patient recruitment and phenotyping, biobanking, and implementing clinical trials for the development of novel treatments that can be employed across the lifespan; a Developmental Genomic/Epigenetics Core (DGC), which will use RNA/exome/whole genome sequencing to uncover intrinsic genetic variation and the contributions of extrinsic (environmental and experiential) factors on epigenetic regulation, and the association of these with IDD; and a Neurocircuitry and Behavior Core (NBC), which will assess both animal and human neural circuit development and function, electrophysiology, and behavior; a 3) a Dissemination and Communication Plan that ensures Hawk-IDDRC research is effectively communicated to the scientific community, educators, policy makers, government officials, and the public, in an engaging and timely manner; and 4) an Educational Program, involving basic and clinical scientists, trainees, the public, and IDD-affected families, and will feature monthly seminars, mentoring of young and talented investigators focused on IDD research, and an educational program aimed at the lay public and IDD community. The Hawk-IDDRC will integrate and capitalize upon strong existing resources in the Hawkeye State: 1) the nationally renowned Center for Disabilities and Development; 2) the Iowa Neuroscience Institute; 3) Iowa’s University Center for Excellence in Developmental Disabilities (UCEDD), and 4) the Iowa Leadership Education in Neurodevelopmental Disabilities (LEND) program. The Center will foster strong existing collaborations between basic and clinical scientists, as well as the IDD community and their families, and support 73 federally funded projects ($28 million per year). The stable, non-transitory rural population in Iowa and an interconnected telehealth system uniquely position Hawk-IDDRC investigators to conduct longitudinal, multi-generational research, for which the University of Iowa is renowned. By providing the infrastructure to direct these outstanding resources, the Hawk-IDDRC will become a leading force in the study of IDD.

项目概要：总体这是一份修订后的申请，旨在建立爱荷华大学“鹰眼”智力与发展学院残疾人研究中心（Hawk-IDDRC），我们的使命是提供一个组织结构，充分整合了整个生命周期（从受孕到成年）的基础和临床研究，重点关注量身定制的智力发育障碍（IDD）的预防、诊断、治疗和改善 Hawk-IDDRC 包括四个部分： 1) Hawk-IDDRC。研究项目将研究幼儿遗传和表观遗传/环境风险的相互作用患有发育障碍，包括自闭症，并整合所有四个研究核心的服务 2) 四个；研究核心将促进跨学科和转化研究，包括：行政核心 (AC) 提供领导力，确保 IDD 研究具有成本效益且严格，同时激励跨学科合作和创新；临床转化核心（CTC），它将应用基础知识通过简化患者招募和表型分析、生物库和实施临床试验以开发可在整个生命周期使用的新疗法；发育基因组/表观遗传学核心 (DGC)，将使用 RNA/外显子组/全基因组测序来揭示内在的遗传变异和外在（环境和经验）因素的贡献表观遗传调控及其与 IDD 的关联；以及神经回路和行为核心 (NBC)，它将评估动物和人类神经回路的发育和功能、电生理学和行为； 3) 确保 Hawk-IDDRC 研究有效的传播和沟通计划向科学界、教育工作者、政策制定者、政府官员和公众传达参与和及时的方式；和 4) 教育计划，涉及基础和临床科学家、受训者、公众和受 IDD 影响的家庭，并将每月举办研讨会，对年轻人和才华横溢的人进行指导研究人员专注于 IDD 研究，以及针对普通公众和 IDD 的教育计划 Hawk-IDDRC 将整合并利用 Hawkeye 强大的现有资源。国家：1）全国著名的残疾与发展中心；2）爱荷华州神经科学研究所； 3) 爱荷华州大学发育障碍卓越中心 (UCEDD)，以及 4) 爱荷华州领导层神经发育障碍教育 (LEND) 项目将促进现有的强大发展。基础科学家和临床科学家以及 IDD 社区及其家人之间的合作，以及支持 73 个联邦政府资助的项目（每年 2800 万美元）。互连的远程医疗系统使 Hawk-IDDRC 调查人员能够进行纵向、爱荷华大学因提供基础设施而闻名。在这些优秀资源的指导下，Hawk-IDDDRC将成为IDD研究的主导力量。