PROSPECTIVE STUDY OF NUTRITION IN THE ELDERLY

老年人营养的前瞻性研究

• 批准号: 2048664
• 负责人: PHILIP J GARRY
• 金额: $ 42.67万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2048664
• 关键词: blood chemistry; body composition; computer data analysis; dietary lipid; dietary proteins; dietary supplements; dietary trace element; gender difference; high performance liquid chromatography; hormone regulation /control mechanism; human middle age (35-64); human morbidity; human mortality; human old age (65+); human subject; immunity; longitudinal human study; magnetic resonance imaging; medical records; muscle metabolism; neuropsychological tests; nutrition of aging; nutrition related tag; parathyroid hormones; physical fitness; psychobiology; psychological tests; radioimmunoassay; vitamin D

ln 1980 we began a prospective study designed to examine the relationship between nutrition and health status in a group of 304 initially healthy individuals. These subjects were recruited in 1979 and were at least 60 years of age, in good health, and taking no prescription medication. Nutritional status was evaluated yearly using three day diet records and biochemical parameters. Health status as determined by a yearly history and physical exam and review of private physician and hospital records when appropriate. In addition, this elderly population was examined periodically for hearing deficits, major life events, cognitive and mental status, and immune status. One goal of this application is to obtain additional longitudinal information on age related changes of nutritional status as determined by yearly clinical, dietary, and biochemical measurements. Two new studies that utilize magnetic resonance imaging (MRl) are proposed that will assess critical outcome variables in this aging population. The first will investigate body composition and changes in fat and muscle mass distribution with aging. In this study, MRl will be used to measure the distribution of fat and muscle directly from three different cross-sectional scans. These data will be used to standardize common anthropometric measurements and to describe the rate of redistribution of fat and muscle in this aging population. The second proposed study will correlate the development of MRl abnormalities in diffuse white matter in the brain, with changes in cognitive status measured by standard neuropsychological exams. This study will continue to supply biological samples for a parallel study designed to analyze the vitamin D-endocrine system for age-related changes in vitamin D nutritional status, renal bioactivation of 25-hydroxy vitamin D, and renal responsiveness to parathyroid hormone.

1980年，我们开始了一项前瞻性研究，旨在检查 304组的营养与健康状况之间的关系 最初健康的个体。 这些主题是在 1979年至少60岁，身体健康，服用 没有处方药。 评估营养状况 每年使用三天的饮食记录和生化参数。 由年度历史和身体检查确定的健康状况 并审查私人医师和医院记录 合适的。 此外，检查了这一老年人 定期用于听力赤字，重大生活事件，认知和 心理状况和免疫状态。 该应用的目标之一是获得额外的纵向 有关年龄相关的营养状况变化的信息 由年度临床，饮食和生化确定 测量。 利用磁共振成像（MRL）的两项新研究是 提出的将评估此衰老的关键结果变量 人口。 第一个将研究身体成分和 脂肪和肌肉质量分布随老化的变化。 在这个 研究，MRL将用于测量脂肪的分布和 直接来自三种不同的横截面扫描的肌肉。 这些 数据将用于标准化常见的人体测量值 并描述脂肪和肌肉重新分布的速度 这个老龄化的人口。 第二项建议的研究将相关 在弥漫性白质中MRL异常的发展 大脑，认知状况的变化通过标准衡量 神经心理学检查。 这项研究将继续为生物样品提供 平行研究旨在分析维生素D-内分泌系统 对于年龄相关的维生素D营养状况的变化，肾脏状况 25-羟基维生素D的生物活化以及对 甲状旁腺激素。