Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling

三叉神经伤害感受器：慢性疼痛和牙槽骨重塑的神经交叉

基本信息

批准号：
10440485
负责人：
Man-Kyo Chung
金额：
$ 99.42万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-08 至 2028-06-30
项目状态：
未结题

项目摘要

Orofacial tissues are richly innervated by nociceptive primary afferents (or nociceptors). Nociceptors transmit pain signals into brain in response to harmful stimuli. Nociceptors also intricately regulate homeostasis of innervated tissues by controlling host responses. Under injury or infection, dysfunctional nociceptors lead to the development of pathological chronic pain and abnormal destructive responses of affected tissues. Dr. Chung’s unique R35 program addresses dual roles of trigeminal nociceptors in two fundamental areas in oral health. Dr. Chung is a dentist scientist, who has devoted his career to craniofacial neuroscience research focused on trigeminal nociceptors. He will continue his ongoing craniofacial pain studies by testing the hypothesis that long-term silencing of nociceptive afferents is analgesic, and that the effects are sufficient to reverse maladaptive neuroplastic changes of brain regions associated with chronic pain. Moreover, Dr. Chung is revisiting his long-term interest in tooth-related neurobiology, and will investigate the neuroimmune and neuroskeletal regulatory mechanisms of alveolar bone destruction and remodeling. He hypothesizes that nociceptive afferents regulate periodontal host responses under periodontal infection or orthodontic force to control pathophysiological remodeling of alveolar bone. Dr. Chung’s research in these areas is aimed at elucidating the mechanisms of chronic pain and alveolar bone remodeling, and their intersection with trigeminal nociceptors. The anticipated outcomes will likely have significant impact, not only in elucidating basic mechanisms but also in translational areas including development of novel methods to control chronic pain and alveolar bone remodeling by regulating nociceptive afferents or nociceptor-enriched molecules.

口面部组织受到伤害性初级传入神经（或伤害感受器传递）的丰富支配。疼痛信号进入大脑以响应有害刺激，也复杂地调节体内平衡。通过控制宿主反应来控制受神经支配的组织在受伤或感染下，伤害感受器功能失调会导致病理性慢性疼痛的发展和受影响组织的异常破坏性反应。 Chung 独特的 R35 程序解决了三叉神经伤害感受器在口腔两个基本领域的双重作用钟博士是一位牙医科学家，致力于颅面神经科学研究。他将通过测试三叉神经伤害感受器来继续他正在进行的颅面疼痛研究。假设长期抑制伤害性传入神经可以起到镇痛作用，并且其效果足以逆转与慢性疼痛相关的大脑区域的适应不良神经塑性变化。正在重新审视他对牙齿相关神经生物学的长期兴趣，并将研究神经免疫和牙槽骨破坏和重塑的神经骨骼调节机制。伤害性传入调节牙周感染或正畸力下的牙周宿主反应 Chung 博士在这些领域的研究旨在控制牙槽骨的病理生理重塑。阐明慢性疼痛和牙槽骨重塑的机制及其与三叉神经的交叉预期的结果可能会产生重大影响，不仅是在阐明基本方面。机制，还包括转化领域，包括开发控制慢性疼痛的新方法和通过调节伤害性传入或富含伤害性感受器的分子来重塑牙槽骨。