A Text-Based Adherence Game for Young People Living with HIV in Ghana

针对加纳艾滋病毒感染者的基于文本的遵守游戏

基本信息

批准号：
10441361
负责人：
Nicholas Tarantino
金额：
$ 17.53万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10441361
关键词：
Achievement Acquired Immunodeficiency Syndrome Address Adherence Adolescent and Young Adult Adult Africa South of the Sahara African Area Belief CD4 Lymphocyte Count Car Phone Caring Cellular Phone Childhood Clinic Clinical Clinical Psychology Cognitive Community Psychology Consult Consultations Counseling Country Coupled Data Development Drops Educational workshop Elements Face Failure Foundations Ghana Goals HIV HIV Infections Health Health Promotion Health Services Accessibility Healthcare Hospitals Infection Internet Intervention Intervention Trial Interview K-Series Research Career Programs Knowledge Life Medical Mentors Mentorship Methodology Modernization Outcome Patients Persons Phase Public Health Qualitative Methods Randomized Reading Research Research Personnel Resource-limited setting Rhode Island Risk Sahara Sampling Scientist Self Management Services Sex Behavior Social Interaction Social support Technical Expertise Testing Text Text Messaging Time Training Training Support United States Universities Viral Viral Load result Vulnerable Populations Work Youth age group antiretroviral therapy base behavioral adherence biobehavior care outcomes career cost design emerging adult experience global health high risk improved innovation mHealth medical schools middle age mobile application novel preference prevent prototype skills social standard of care substance use symposium theories therapy adherence therapy development transmission process two way texting young adult

项目摘要

PROJECT SUMMARY Maintaining adherence to HIV treatment is a challenge and nonadherence is associated with heightened risks for secondary HIV transmission and poor health outcomes. In sub-Saharan Africa, an estimated one in three patients do not take antiretroviral therapy (ART) as prescribed and one in four disengage from treatment within a year of initiating ART. Adherence to care outcomes are even worse among older adolescents and young adults (young people) living with HIV (YPLH) who experience the highest rates of ART nonadherence, treatment attrition, and virologic failure compared to other age groups. Consistent with the Division of AIDS Research’s areas of High Priority, the current project targets YPLH using a novel mHealth gaming intervention in order to promote their adherence to HIV care. Candidate: The candidate is a clinical scientist with a background in clinical and community psychology. His prior research focuses on the development of interventions to prevent HIV infection among underserved youth, primarily in the United States (U.S.). He is applying for a five-year K23 Career Development Award in order to expand his expertise and support his training, mentorship, and research within a novel area of intervention in a sub-Sahara African country (Ghana). Mentoring: Six well-established researchers serve as mentors on this proposal. Each brings complimentary expertise consistent with the study’s aims and training objectives. Dr. Larry Brown is the Primary Mentor and has experience in creating mobile gaming interventions for YPLH in the U.S. Four other mentors are HIV-focused investigators with expertise in global health research (Dr. Matthew Mimiaga), studies in Ghana (Drs. Awewura Kwara and Margaret Lartey), and applied qualitative methods (Dr. Kate Guthrie). Dr. Beth Bock is an expert in mHealth interventions including the use of text messages to address substance use. Research: The aims of the proposed project are to (1) gather information on the barriers and facilitators to adherence to care among YPLH attending an HIV clinic in Ghana and gauge YPLH preferences for an mHealth intervention via in-depth interviews with YPLH , their treatment buddies, and clinic staff; (2) develop a Text- Based Adherence Game to promote adherence to care by consulting with an mHealth developer and conducting an iterative open trial of the intervention with YPLH (n = 24); and (3) evaluate the intervention for feasibility and preliminary efficacy with a small randomized pilot examining biobehavioral adherence outcomes over one year in a sample of YPLH who receive the Text-Based Adherence Game versus YPLH who receive the standard of care (n = 60). Training: Specific training overseen by the mentorship team through formal coursework, workshops, seminars, conferences, directed readings, clinical work, and mentored experiences will be received by the candidate. Areas of focus include HIV-focused research in sub-Saharan Africa, broadly, and in Ghana, specifically; methodological and technical mHealth skills; and knowledge of gamification. The candidate is institutionally supported by Rhode Island Hospital and the Alpert Medical School of Brown University.

项目概要保持对艾滋病毒治疗的依从性是一项挑战，不依从性与胃肠道风险相关在撒哈拉以南非洲地区，估计有三分之一的人患有继发性艾滋病毒传播和不良健康结果。患者没有按照规定接受抗逆转录病毒治疗 (ART)，四分之一的患者放弃治疗开始抗逆转录病毒疗法一年内，老年青少年和青少年对护理结果的依从性甚至更差。感染艾滋病毒的年轻人（YPLH）不遵守抗逆转录病毒疗法的比例最高，与其他年龄组相比，治疗减员和病毒学失败与艾滋病的划分一致。研究的高优先级领域，当前项目使用新颖的移动医疗游戏干预措施来针对 YPLH 为了促进他们坚持艾滋病毒护理候选人：候选人是一名临床科学家，拥有博士学位。他之前的研究重点是临床和社区心理学的发展。预防服务不足的青少年感染艾滋病毒的干预措施，主要是在美国（美国）。申请五年 K23 职业发展奖，以扩展他的专业知识并支持他的在撒哈拉以南非洲国家的新干预领域内进行培训、指导和研究（加纳）：六名知名研究人员担任该提案的导师。拉里·布朗博士是与该研究的目的和培训目标相一致的免费专业知识。主要导师，拥有为美国 YPLH 创建移动游戏干预措施的经验其他四名导师是专注于艾滋病毒的研究人员，具有全球健康研究的专业知识（Matthew Mimiaga 博士）、研究在加纳（Awewura Kwara 博士和 Margaret Lartey），并应用定性方法（Kate Guthrie 博士）。 Beth Bock 是移动医疗干预领域的专家，包括使用短信来解决药物滥用问题。研究：拟议项目的目的是（1）收集有关障碍和促进因素的信息前往加纳 HIV 诊所就诊的 YPLH 的护理依从性，并评估 YPLH 对移动医疗的偏好通过深入访谈 YPLH、他们的治疗伙伴和诊所工作人员进行干预；(2) 制定文本- 基于依从性游戏，通过咨询移动医疗开发商并进行指导来促进对护理的依从性 YPLH 干预措施的迭代开放试验（n = 24）；以及 (3) 评估干预措施的可行性以及通过一项小型随机试验检查生物行为依从性结果的初步效果年接受基于文本的遵守游戏的 YPLH 与接受标准的 YPLH 样本护理（n = 60）：指导团队通过正式课程进行具体培训监督，将收到讲习班、研讨会、会议、定向阅读、临床工作和指导经验重点领域包括撒哈拉以南非洲地区和加纳的艾滋病毒研究，具体来说，候选人的方法论和技术技能；以及游戏化知识。得到罗德岛医院和布朗大学阿尔珀特医学院的机构支持。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Impact of Different Parental Figures of Adolescents Living With HIV: An Evaluation of Family Structures, Perceived HIV Related Stigma, and Opportunities for Social Support.

不同父母形象对艾滋病毒青少年的影响：对家庭结构、艾滋病毒相关耻辱感和社会支持机会的评估。

DOI：
发表时间：
2022
期刊：
影响因子：
0
作者：
Wowolo, Gloria;Cao, Wangnan;Bosomtwe, Dennis;Enimil, Anthony;Tarantino, Nicholas;Barker, David H;Galárraga, Omar
通讯作者：
Galárraga, Omar

Correction to: A Review of Interventions to Enhance HIV Medication Adherence.

更正：增强艾滋病毒药物依从性的干预措施回顾。

DOI：
发表时间：
2021-10
期刊：
影响因子：
4.6
作者：
Whiteley, Laura B;Olsen, Elizabeth M;Haubrick, Kayla K;Odoom, Enyonam;Tarantino, Nicholas;Brown, Larry K
通讯作者：
Brown, Larry K

Using behavioral psychotherapy techniques to address HIV patients' pain, depression, and well-being.

使用行为心理治疗技术来解决艾滋病毒患者的疼痛、抑郁和健康问题。

DOI：
发表时间：
2020
期刊：
影响因子：
0
作者：
Moitra, Ethan;Tarantino, Nicholas;Garnaat, Sarah L;Pinkston, Megan M;Busch, Andrew M;Weisberg, Risa B;Stein, Michael D;Uebelacker, Lisa A
通讯作者：
Uebelacker, Lisa A