Leveraging Community-Academic Partnerships and Social Networks to Disseminate Vaccine-Related Information and Increase Vaccine Uptake Among Black Individuals with Rheumatic Diseases

利用社区学术合作伙伴关系和社交网络传播疫苗相关信息并提高患有风湿病的黑人个体的疫苗接种率

• 批准号: 10442270
• 负责人: Candace Hillary Feldman
• 金额: $ 79.1万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-10 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10442270
• 关键词: Address; Advocacy; Area; Arthritis; Assessment tool; Black Populations; Black race; Boston; COVID-19 pandemic; COVID-19 stress; COVID-19 vaccination; COVID-19 vaccine; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Chicago; Chronic; Cities; Clinical Trials; Communicable Diseases; Communities; Disease Outcome; Education; Educational Curriculum; Educational Intervention; Enrollment; Evaluation; Exhibits; Fright; General Population; Goals; Health; Immunocompromised Host; Individual; Infection; Information Dissemination; Intervention; Interview; Justice; Knowledge; Lupus; Maps; Methods; Modeling; Outcome; Patients; Persons; Pharmaceutical Preparations; Physicians; Play; Population; Positioning Attribute; Process; Public Health; Race; Randomized; Randomized Controlled Trials; Recommendation; Regimen; Research; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Role; SARS-CoV-2 infection; Safety; Social Network; Societies; Structural Racism; Structure; Systemic Lupus Erythematosus; Testing; Training; Training Activity; Trust; Underrepresented Minority; Vaccinated; Vaccination; Vaccines; Work; acute care; adverse outcome; arm; base; black patient; comorbidity; density; design; evidence base; experience; health care availability; health care disparity; high risk; immunosuppressed; improved; lens; low socioeconomic status; member; mortality; outreach; people of color; physically handicapped; racial and ethnic disparities; racism; recruit; response; severe COVID-19; social health determinants; socioeconomic disparity; standard of care; theories; transmission process; treatment arm; uptake; vaccine acceptance; vaccine efficacy; vaccine hesitancy; vaccine response; vaccine safety; virtual

PROJECT SUMMARY Individuals with chronic rheumatic diseases including arthritis comprise approximately 25% of the U.S. population. Racial/ethnic and socioeconomic disparities in adverse, often avoidable outcomes occur in nearly all rheumatic diseases particularly among Black and lower socioeconomic status individuals. Despite the importance of vaccinations in patients with rheumatic diseases, and the high rates of serious infections, vaccine uptake is consistently poor. In the U.S., COVID-19 vaccine uptake is lower and vaccine hesitancy higher among Black patients compared with White patients, and this holds true in rheumatic diseases. With the profound disparities uncovered by the COVID-19 pandemic aggravated by proven disparities in rheumatic disease outcomes, and heightened vulnerability to infections, there is an urgent need to address low vaccine uptake and hesitancy among Black individuals with these conditions. In addition, it is critical to also increase vaccine uptake among the social networks of individuals with rheumatic diseases who are immunosuppressed and may have less robust vaccination responses. Our team has forged longstanding community-academic partnerships in the Boston and Chicago areas to understand the needs of Black individuals with lupus, a systemic rheumatic disease, and the role racism plays in health and healthcare access. Framed by the Public Health Critical Race Praxis that recognizes the pervasiveness of racism in our society, we will leverage our community-academic partnerships to implement the CDC's Popular Opinion Leader (POL) model whereby trusted community leaders are trained to disseminate information regarding COVID-19 vaccination through their social networks in predominately Black communities to increase vaccine uptake and reduce hesitancy. In response to the NOSI NOT-MD-21-008: Research to Address Vaccine Hesitancy, Uptake and Implementation among Populations that Experience Disparities, we propose the following aims: Aim 1. To leverage community- academic partnerships across two U.S. cities to develop training and evaluation materials for POLs. Aim 2a. To establish the efficacy of a community-based intervention with and without a racial justice framework to increase COVID-19 vaccine uptake and reduce hesitancy among social networks of Black individuals with rheumatic conditions. We will conduct a cluster randomized controlled trial to test whether POLs trained with racial justice framing embedded in information on vaccine safety and efficacy will result in greater COVID-19 vaccine uptake among their social network members compared to safety and efficacy training alone. Aim 2b. To determine the structure and composition of the outreach social networks of POLs. We will enhance the existing POL model by adding a validated mixed methods approach to compare the social networks reached by POLs in each arm. We hypothesize that incorporating a racial justice lens will empower POLs to disseminate information more broadly and more persuasively and increase vaccine uptake by reducing fear and mistrust.

项目概要 患有包括关节炎在内的慢性风湿性疾病的人约占美国人口的 25%。 人口。种族/族裔和社会经济差异导致的不利的、通常可以避免的结果几乎发生在 所有风湿病，特别是黑人和社会经济地位较低的人。尽管 风湿性疾病患者接种疫苗的重要性以及严重感染的高发生率， 疫苗接种率一直很低。在美国，COVID-19 疫苗接种率较低且对疫苗犹豫不决 与白人患者相比，黑人患者的患病率更高，这在风湿性疾病中也是如此。随着 COVID-19 大流行揭示了巨大的差异，而风湿病方面已证实的差异又加剧了这一差异 疾病结果以及感染的脆弱性增加，迫切需要解决疫苗接种率低的问题 患有这些疾病的黑人个体的接受和犹豫。此外，还必须增加 免疫抑制的风湿病患者社交网络中的疫苗接种情况 并且疫苗接种反应可能不太强烈。我们的团队已经建立了长期的社区学术 波士顿和芝加哥地区的合作伙伴关系，以了解患有狼疮的黑人个体的需求， 系统性风湿病，以及种族主义在健康和医疗保健获取中发挥的作用。被公众陷害 认识到种族主义在我们社会中普遍存在的健康关键种族实践，我们将利用我们的 社区-学术伙伴关系，以实施 CDC 的大众意见领袖 (POL) 模式，其中 值得信赖的社区领袖接受过培训，可以通过以下方式传播有关 COVID-19 疫苗接种的信息： 他们在以黑人为主的社区建立社交网络，以提高疫苗接种率并减少犹豫。在 对 NOSI NOT-MD-21-008 的回应：解决疫苗犹豫、采用和实施的研究 针对经历差异的人群，我们提出以下目标： 目标 1. 利用社区- 美国两个城市的学术合作伙伴关系，为 POL 开发培训和评估材料。目标 2a。到 确定有或没有种族正义框架的基于社区的干预措施的有效性，以提高 COVID-19 疫苗的接种并减少患有风湿病的黑人社交网络中的犹豫 状况。我们将进行整群随机对照试验，以测试 POL 是否受过种族正义培训 疫苗安全性和有效性信息中嵌入的框架将提高 COVID-19 疫苗的使用率 在他们的社交网络成员中与单独的安全性和有效性培训进行比较。目标 2b。确定 POL 的外展社交网络的结构和组成。我们将增强现有的 POL 模型 通过添加经过验证的混合方法来比较每个臂中 POL 所达到的社交网络。 我们假设纳入种族正义视角将使 POL 能够更多地传播信息 更广泛、更有说服力，并通过减少恐惧和不信任来提高疫苗接种率。