Mentoring and Patient-Oriented Research on Social Exposures and CVD Risk in Underrepresented Women

针对代表性不足的女性的社会暴露和心血管疾病风险的指导和以患者为导向的研究

基本信息

批准号：
10440016
负责人：
Tené T Lewis
金额：
$ 12.38万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10440016
关键词：
African American Age Animal Model Antral Automobile Driving Award Biological Assay Biological Markers Blood specimen Body mass index Cardiology Cardiovascular Diseases Chronology Collaborations Consultations Data Development Discipline Discrimination Disease Doctor of Philosophy Education Educational workshop Emotional Epidemiology Estrogens Exposure to Family Fellowship Program Female Financial Hardship Follicle Stimulating Hormone Fostering Friends Funding Future Genetic Goals Grant Health Health Services Accessibility Hormones Knowledge Link Master of Public Health Measures Menopause Menstrual cycle Mentors Meta-Analysis Modeling Morbidity - disease rate National Heart, Lung, and Blood Institute Outcome Ovarian Ovarian aging Parents Physiologic pulse Physiological Pilot Projects Play Premature Menopause Premenopause Process Public Health Schools Records Reporting Research Research Personnel Risk Risk Factors Role Science Smoking Socioeconomic Status Study of Women&apos s Health Across the Nation Subgroup System Time Training Training Programs Underrepresented Populations Universities Vulnerable Populations Weather Woman Women&apos s Group Women&apos s Health aged black/white disparity cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health cardiovascular risk factor career cohort design diminished ovarian reserve health inequalities interest intima media medical schools men middle age minority scientist mortality mullerian-inhibiting hormone multidisciplinary multimodality nonhuman primate ovarian reserve patient oriented patient oriented research programs prospective racial and ethnic reproductive reproductive senescence skills social social stress social stressor sociodemographics stress management supportive environment therapy design ultrasound

项目摘要

PROJECT SUMMARY This Mid-Career Investigator Award in Patient-Oriented Research is designed to provide Dr. Tené T. Lewis with protected time and other support to: 1) advance her current program of research, focused on understanding how social stressors contribute to cardiovascular disease (CVD) risk in underrepresented and understudied groups of women; 2) accelerate a successful record of mentoring junior patient-oriented researchers across disciplines, with an emphasis on trainees historically underrepresented in research (e.g. racial/ethnic minority scientists); 3) enhance her mentoring skills, with a particular focus on transdisciplinary approaches and best-practices in providing mentoring and support to underrepresented groups; and 4) obtain training in the examination of biomarkers of ovarian aging, as emerging risk factors for CVD in women. Mentoring activities will leverage Dr. Lewis’ ongoing involvement in several training programs at Emory University, including an NHLBI-funded multidisciplinary T32 training grant on cardiovascular health inequities that she co-directs, the research-track Cardiology fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in Epidemiology at the Rollins School of Public Health. Mentoring training will occur via workshops and regular consultation with senior investigators with established track records in mentoring of patient-oriented researchers from a range of disciplinary and sociodemographic backgrounds. Training in ovarian aging will build upon Dr. Lewis’ existing collaborations at Emory and with the Study of Women’s Health Across the Nation (SWAN). Finally, the science proposed in the award will extend Dr. Lewis’ research in critically important new directions, by examining ovarian aging as a biologically plausible mechanism that might further contribute to our understanding of how social stressors impact subclinical CVD in vulnerable subgroups of women (particularly African-American women) highlighting processes occurring at midlife, when excess rates are most pronounced.

项目概要该以患者为导向的研究领域的职业中期研究员奖旨在为 Tené T. Lewis 博士提供帮助在受保护的时间和其他支持下：1）推进她当前的研究计划，重点是了解社会压力因素如何导致代表性不足和代表性不足的人群的心血管疾病 (CVD) 风险 2) 加速以患者为导向的初级指导的成功记录跨学科的研究人员，重点关注历史上在研究中代表性不足的受训者（例如， 3）提高她的指导技能，特别关注跨学科为代表性不足的群体提供指导和支持的方法和最佳实践；以及 4) 获得卵巢衰老生物标志物检查培训，作为女性心血管疾病的新危险因素。指导活动将利用刘易斯博士持续参与埃默里大学的多个培训项目大学，包括 NHLBI 资助的关于心血管健康不平等的多学科 T32 培训补助金她共同领导了医学院的研究型心脏病学奖学金计划，以及罗林斯公共卫生学院公共卫生硕士和流行病学博士课程。培训将通过讲习班和定期与高级调查员协商的方式进行指导来自一系列学科和社会人口学的以患者为中心的研究人员的记录卵巢衰老方面的培训将建立在刘易斯博士在埃默里大学以及与该机构的现有合作的基础上。最后，该奖项提出的科学将得到扩展。刘易斯博士的研究至关重要的新方向，通过检查卵巢衰老作为生物学上合理的因素机制可能进一步有助于我们理解社会压力因素如何影响亚临床心血管疾病弱势妇女群体（特别是非洲裔美国妇女）强调了发生在中年，超率最为明显。