CLINICAL PSYCHOPHARMACOLOGY COMPUTER LABORATORY

临床精神药理学计算机实验室

• 批准号: 2244329
• 负责人: JOHN E OVERALL
• 金额: $ 7.26万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2244329
• 关键词: clinical trials; computer simulation; health science research analysis /evaluation; human data; psychometrics; psychopharmacology; statistics /biometry; technology /technique development

This project is concerned with enhancing validity and power of neuropsychopharmacologic research and service delivery through refinements in design and analysis of controlled clinical trials, development and/or evaluation of clinical assessment and classification methodology, as well as the provision of statistical support for selected clinical investigators. Flexibility in focusing on key methodological issues as they arise has been a unique feature of this NIMH grant in the past. Evaluating neuropsychopharmacologic treatments in the broader service delivery context is a currently added emphasis that poses novel methodological problems and possibilities. Statistical issues to be examined include the best among imperfect ways of controlling for confounding factors in doctor's choice treatment settings and methodology for investigating differences in frequencies of occurrence of rare events which can only be studied in the broader service delivery context. Computer models, monte carlo simulation methods, and logical analysis will be used to examine key issues in the methodology for evaluating neuropsychopharmacologic treatments. The importance of an independent academic participation in issues that arise at the interface of industry and the FDA is stressed.

该项目致力于增强有效性和力量 通过改进进行神经精神药理学研究和服务提供 受控临床试验的设计和分析、开发和/或 临床评估和分类方法的评估，以及 为选定的临床提供统计支持 调查人员。 灵活地关注关键方法问题，例如 它们的出现是 NIMH 过去拨款的一个独特特征。 评估更广泛服务中的神经精神药物治疗 交付环境是当前增加的重点，提出了新颖的 方法论问题和可能性。 统计问题有待解决 研究的内容包括不完美的控制方法中最好的 医生选择治疗环境和方法的混杂因素 用于调查罕见事件发生频率的差异 这只能在更广泛的服务提供背景下进行研究。 计算机模型、蒙特卡罗模拟方法和逻辑分析将 用于检查评估方法中的关键问题 神经精神药物治疗。 独立的重要性 学术界参与工业界出现的问题 FDA 压力很大。