CLINICAL PSYCHOPHARMACOLOGY COMPUTER LABORATORY

临床精神药理学计算机实验室

• 批准号: 3375336
• 负责人: JOHN E OVERALL
• 金额: $ 13.05万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375336
• 关键词: behavior test; diagnosis quality /standard; disease /disorder classification; drug metabolism; mathematical model; mental disorder diagnosis; psychometrics; psychopharmacology; psychophysiology; schizophrenia; statistics /biometry

The aims of the Clinical Psychopharmacology Computer Laboratory are to provide quantitative and computer support for clinical psychopharmacology research through collaborative participation in projects conducted by investigators in our institutional setting and in other institutions as well. Different levels of involvement in different projects will extend from participation in actual data collection to the providing of specific specialized services such as computer classification of symptom profiles of patients who are research subjects. In addition to collaborative research support functions, activities supported by the grant will include (a) development and/or evaluation of measuring instruments and assessment devices having potential applications in clincal psychopharmacology research, (b) development and/or evaluation of diagnostic criteria and classification procedure for defining research populations, (c) development and/or evaluation of new statistical methods having potential applications in clinical psychopharmacology research. The methodology employed in pursuit of these aims will be statistical or psychometric. Standard statistical methods such as general linear model analysis of variance or covariance, as well as powerful quantitative models for ellucidation of multivariate relationships, are available for use in analysis of clinical data. Monte carlo methods will be relied on heavily in evaluating the performance of statistical tests under conditions simulating those encountered in clinical research, and exact methods will be used to calculate probabilities of Type I an Type II errors in other cases.

临床精神药理学计算机实验室的目标是 为临床精神药理学提供定量和计算机支持 通过合作参与项目进行的研究 我们的机构环境和其他机构中的调查员 出色地。 不同项目的不同参与程度将延长 从参与实际数据收集到提供具体数据 专业服务，例如症状特征的计算机分类 作为研究对象的患者。 除了合作研究 赠款支持的支持职能和活动将包括 (a) 测量仪器的开发和/或评估和评估 在临床精神药理学中具有潜在应用的设备 研究，(b) 诊断标准的制定和/或评估以及 定义研究群体的分类程序，(c) 发展 和/或评估具有潜在应用的新统计方法 从事临床精神药理学研究。 所采用的方法 追求这些目标将是统计或心理测量的。 标准 统计方法，例如一般线性模型方差分析或 协方差，以及用于阐明的强大定量模型 多变量关系，可用于临床分析 数据。 蒙特卡罗方法将在很大程度上依赖于评估 在模拟这些条件下进行统计测试的性能 临床研究中遇到的情况，将采用准确的方法 计算其他情况下出现 I 类和 II 类错误的概率。